This just doesn't sound good

Posted by linkadge on May 1, 2010, at 19:46:15

http://bloodjournal.hematologylibrary.org/cgi/content/full/101/8/3212
Here we show that 3 structurally distinct SSRIsfluoxetine, paroxetine, and citalopramact directly on Burkitt lymphoma (BL) cells to trigger rapid and extensive programmed cell death. SSRIs unexpectedly stimulated calcium flux, tyrosine phosphorylation, and down-regulation of the c-myc and nm23 genes in Burkitt lymphoma cells remaining faithful to the biopsy phenotype. Resultant SSRI-induced apoptosis was preceded by caspase activation, poly(ADP-ribose) polymerase-1 (PARP-1) cleavage, DNA fragmentation, a loss of mitochondrial membrane potential, and the externalization of phosphatidylserine, and reversed by the overexpression of bcl-2.

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This just doesn't sound good linkadge 5/1/10
Re: This just doesn't sound good » linkadge Phillipa 5/2/10
Re: This just doesn't sound good ed_uk2010 5/2/10
Re: This just doesn't sound good bleauberry 5/3/10

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