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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by inanimate peanut on January 5, 2010, at 12:35:45
I finally got my NAC (N- Acetyl Cysteine) in the mail. I haven't found any interactions with MAOIs. I think I will wait a couple more days to let everything settle before starting it (and to make sure none of you terribly resourceful people don't find an interaction with MAOIs somewhere!)
Posted by willey on January 5, 2010, at 13:04:15
In reply to N-Acetyl-Cysteine (NAC) and Parnate, posted by inanimate peanut on January 5, 2010, at 12:35:45
Know what i keep failing to ask,or i did ask but it slipped by that would prob make things a lot simpler.
What exactly are you trying to obtain?A more roubust anti depressant addition,a more effective anti anxiety drug,any particular symtpoms ur left with trying to treat,if u state a reason for search of augments it would help people here recomend the safe compounds that u can look into.
P.s for the board,im in no way sure,but just at a glance,and again i havent fully looked,with hard effort since they constantly hide it,and i mean constantly within includment of other drugs,the singled out death toll of benzos yearly.So far the awful drug helping millions has beeb responable for about 7 deaths ayear,im real curious to know now if this is true,if it were id be in awe of the publics negative view on them
Posted by Phillipa on January 5, 2010, at 13:04:38
In reply to N-Acetyl-Cysteine (NAC) and Parnate, posted by inanimate peanut on January 5, 2010, at 12:35:45
When's that pdoc appointment. Stay safe. Phillipa
Posted by inanimate peanut on January 5, 2010, at 16:13:43
In reply to Re: hmmmm, posted by willey on January 5, 2010, at 13:04:15
I'm trying to get rid of the residual depression that keeps me from functioning. My anxiety level is actually pretty good. The Parnate has stopped me from being suidical or crying all the time, which I am thankful for beyond words. Now I just find no pleasure in living, have no motivation, and can't make myself do anything that needs to be done.
The only sense of purpose I have is to try to get better. I'm on leave from work now, but that runs out March 26, and if I have to go back without getting better than this I know I will lose my job. If I lose my job, I lose my apartment, insurance, meds, etc. So I'm kind of hurrying on a deadline here since I only can trial so many things before March 26. At this point, I'm making a list of things to try, hence so many questions about this and that, and then I'll decide what order to try them in.
Posted by inanimate peanut on January 5, 2010, at 22:08:39
In reply to N-Acetyl-Cysteine (NAC) and Parnate, posted by inanimate peanut on January 5, 2010, at 12:35:45
Just in case anyone was interested, here's the study about N-Acetyl Cysteine and bipolar depression: If anyone can find the full article, I would really like to know what dose they were taking and whether it was with food or on an empty stomach. Thanks!
Biol Psychiatry. 2008 Sep 15;64(6):468-75. Epub 2008 Jun 5.
N-acetyl cysteine for depressive symptoms in bipolar disorder--a double-blind randomized placebo-controlled trial.
Berk M, Copolov DL, Dean O, Lu K, Jeavons S, Schapkaitz I, Anderson-Hunt M, Bush AI.The Mental Health Research Institute of Victoria, Victoria, Australia.
Comment in:Biol Psychiatry. 2008 Nov 1;64(9):e1.
BACKGROUND: Treatment-resistant subthreshold depression is a major problem in bipolar disorder. Both depression and bipolar disorder are complicated by glutathione depletion. We hypothesized that treatment with N-acetyl cysteine (NAC), a safe, orally bioavailable precursor of glutathione, may improve the depressive component of bipolar disorder. METHODS: A randomized, double-blind, multicenter, placebo-controlled study of individuals (n = 75) with bipolar disorder in the maintenance phase treated with NAC (1 g twice daily) adjunctive to usual medication over 24 weeks, with a 4-week washout. The two primary outcomes were the Montgomery Asberg Depression Rating Scale (MADRS) and time to a mood episode. Secondary outcomes included the Bipolar Depression Rating Scale and 11 other ratings of clinical status, quality of life, and functioning. RESULTS: NAC treatment caused a significant improvement on the MADRS (least squares mean difference [95% confidence interval]: -8.05 [-13.16, -2.95], p = .002) and most secondary scales at end point. Benefit was evident by 8 weeks on the Global Assessment of Functioning Scale and Social and Occupational Functioning Assessment Scale and at 20 weeks on the MADRS. Improvements were lost after washout. There was no effect of NAC on time to a mood episode (log-rank test: p = .968) and no significant between-group differences in adverse events. Effect sizes at end point were medium to high for improvements in MADRS and 9 of the 12 secondary readouts. CONCLUSIONS: NAC appears a safe and effective augmentation strategy for depressive symptoms in bipolar disorder.
Posted by janejane on January 6, 2010, at 7:11:49
In reply to NAC good for bipolar depression, posted by inanimate peanut on January 5, 2010, at 22:08:39
The summary says they were taking 1 gram twice daily. Doesn't say whether they were taking it with food, but you could probably look up what the usual recommendations are for that.
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