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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 21 of 21. This is the beginning of the thread.
Posted by inanimate peanut on January 3, 2010, at 17:08:09
Surely this one is safe, right? It's just an amino acid for gosh sake. Has anyone had any good results from supplementing with tyrosine? I have 2 protein shakes per day that have tyrosine in them but apparently tyrosine has to complete with other amino acids to be transported across the blood-brain barrier, so I thought supplementing it alone would give it an advantage. This is why supplementing with phenylalanine (or other amino acids) might make your dopamine problem worse, since (even though some phenylalanine is converted to tyrosine), the two compete for transport across the blood-brain barrier. What do you think?
Posted by janejane on January 3, 2010, at 18:01:07
In reply to L-Tyrosine and Parnate, posted by inanimate peanut on January 3, 2010, at 17:08:09
Sorry, but I looked at several different sources, and tyrosine is contraindicated with MAOIs. I'm not sure that means you have to completely rule out the possibility, but you should definitely be extremely cautious and ask your doctor before trying it. Maybe you can put it on the list of stuff to ask about at Stanford.
Posted by Phillipa on January 3, 2010, at 18:04:56
In reply to Re: L-Tyrosine and Parnate » inanimate peanut, posted by janejane on January 3, 2010, at 18:01:07
Good memory when you off to Stanford? Phillipa
Posted by inanimate peanut on January 3, 2010, at 18:48:48
In reply to Re: L-Tyrosine and Parnate, posted by Phillipa on January 3, 2010, at 18:04:56
My appointment is January 19.
Posted by willey on January 3, 2010, at 20:18:19
In reply to Re: L-Tyrosine and Parnate » Phillipa, posted by inanimate peanut on January 3, 2010, at 18:48:48
You are really anxious about parnate i see,not sure ur situation,i.e if ur already on it or so on,but i hate to be the bearer of bad news yet again,BUT NO absolutly not,neither tyorsine,nor phenyline should EVER be used with parnate.
Have u look at MIRAPEXl this should be safe as well as modfanil.
Posted by Phillipa on January 3, 2010, at 20:36:01
In reply to Re: L-Tyrosine and Parnate » Phillipa, posted by inanimate peanut on January 3, 2010, at 18:48:48
Make sure you post how it goes. Phillipa
Posted by inanimate peanut on January 3, 2010, at 21:23:21
In reply to Re: L-Tyrosine and Parnate, posted by willey on January 3, 2010, at 20:18:19
willey-- you have the funniest timing! I was just about to post about RU486, Mirapex, Celebrex, Provigil, and Zonisamide as possible options
I also just read that just supplementing tyrosine would do me no good anyway. It has to be in the form of tyrosine hydroxylase to do any good.
Posted by Charles Darwood on January 12, 2010, at 23:23:41
In reply to L-Tyrosine and Parnate, posted by inanimate peanut on January 3, 2010, at 17:08:09
Dr. Wes Burgess _recommends_ supplementing tranylcypromine with tyrosine.
http://www.amazon.com/Bipolar-Handbook-Real-Life-Up-Date/dp/1583332499
[Page 98]
Posted by Deneb on January 13, 2010, at 1:42:50
In reply to Re: L-Tyrosine and Parnate, posted by Charles Darwood on January 12, 2010, at 23:23:41
Hello Charles Darwood!
Welcome to Psycho-Babble! Thanks for that information, I'm sure lots of people will find it useful.
Deneb
Posted by inanimate peanut on January 13, 2010, at 15:04:22
In reply to Re: L-Tyrosine and Parnate » Charles Darwood, posted by Deneb on January 13, 2010, at 1:42:50
Thanks Charles!
Search inside the book has indeed demonstrated that you are correct. At least he or his patients have obviously not had negative effect supplementing with tyrosine while on Parnate.
Posted by bulldog2 on January 13, 2010, at 15:59:23
In reply to Re: L-Tyrosine and Parnate, posted by Charles Darwood on January 12, 2010, at 23:23:41
> Dr. Wes Burgess _recommends_ supplementing tranylcypromine with tyrosine.
>
> http://www.amazon.com/Bipolar-Handbook-Real-Life-Up-Date/dp/1583332499
>
> http://books.google.com/books?id=27eBNgZ48lIC&printsec=frontcover&dq=the+bi+polar+handbook&cd=1#v=onepage&q=&f=false
>
> [Page 98]I can't seem to find the page. What did he say about tyrosine and parnate. What dosages. DL-phenyalanine might also be good as you get a conversion to tyrosine and pea.
Posted by inanimate peanut on January 13, 2010, at 17:13:45
In reply to Re: L-Tyrosine and Parnate, posted by bulldog2 on January 13, 2010, at 15:59:23
All I did was go to search inside the book and type tyrosine. It's the only appearance of the word in the whole book. It's almost an afterthought. Like, oh yeah, and some people on parnate complain of sedation. I suggest they supplement with tyrosine.
Posted by bulldog2 on January 14, 2010, at 10:43:19
In reply to Re: L-Tyrosine and Parnate, posted by inanimate peanut on January 13, 2010, at 17:13:45
> All I did was go to search inside the book and type tyrosine. It's the only appearance of the word in the whole book. It's almost an afterthought. Like, oh yeah, and some people on parnate complain of sedation. I suggest they supplement with tyrosine.
Look for tyrosine in the first or second link.
Posted by bulldog2 on January 14, 2010, at 16:14:16
In reply to Re: L-Tyrosine and Parnate, posted by inanimate peanut on January 13, 2010, at 17:13:45
> All I did was go to search inside the book and type tyrosine. It's the only appearance of the word in the whole book. It's almost an afterthought. Like, oh yeah, and some people on parnate complain of sedation. I suggest they supplement with tyrosine.
I found something that recommends it for gorgginess with parnate. But no dosage recommendations for safe usage.
Posted by inanimate peanut on January 14, 2010, at 16:41:50
In reply to Re: L-Tyrosine and Parnate, posted by bulldog2 on January 14, 2010, at 16:14:16
That is true. It kind of leaves the reader to figure that out for themselves. It would have been nice to have a bit more info!
Posted by bulldog2 on January 14, 2010, at 17:27:26
In reply to Re: L-Tyrosine and Parnate, posted by inanimate peanut on January 14, 2010, at 16:41:50
> That is true. It kind of leaves the reader to figure that out for themselves. It would have been nice to have a bit more info!
As I mentioned before dl-phenylalanine might be good. some becomes tyrosine and some pea which is also very good for the mood.
Posted by Charles Darwood on January 14, 2010, at 20:22:29
In reply to Re: L-Tyrosine and Parnate, posted by bulldog2 on January 14, 2010, at 17:27:26
I think this is of some relevance:
From Birkmayer W, Riederer P, Linauer W, Knoll
Journal of Neural Transmission. 1984: 59(1):81-7:"The antidepressive efficacy of 1-deprenyl (5-10 mg daily) plus 1-phenylalanine (250 mg/day) has been evaluated in 155 unipolar depressed patients. Both oral and intravenous administration showed beneficial effects in 90% of outpatients and 80.5% of inpatients. It is concluded that this combined treatment has a potent antidepressive action based on the accumulation of 1-phenylethylamine in the brain."
If it works for selegiline, I would assume it would work for tranylcypromine. However, in my experience, neither DL-phenylalanine nor tyrosine has had much effect on my mood, but maybe I'm just in that unfortunate 10% category. I did stir a gram of phenethylamine into a double espresso once and drank it with parnate and felt a not-unpleasant buzz for a couple of hours.
I have read that increased catecholamine synthesis depresses serotonin levels, so perhaps one should augment with 5HTP as well. By that point, however, it's probably safer to use cocaine.
Posted by bulldog2 on January 15, 2010, at 15:09:57
In reply to Re: L-Tyrosine and Parnate, posted by Charles Darwood on January 14, 2010, at 20:22:29
> I think this is of some relevance:
>
> From Birkmayer W, Riederer P, Linauer W, Knoll
> Journal of Neural Transmission. 1984: 59(1):81-7:
>
> "The antidepressive efficacy of 1-deprenyl (5-10 mg daily) plus 1-phenylalanine (250 mg/day) has been evaluated in 155 unipolar depressed patients. Both oral and intravenous administration showed beneficial effects in 90% of outpatients and 80.5% of inpatients. It is concluded that this combined treatment has a potent antidepressive action based on the accumulation of 1-phenylethylamine in the brain."
>
> If it works for selegiline, I would assume it would work for tranylcypromine. However, in my experience, neither DL-phenylalanine nor tyrosine has had much effect on my mood, but maybe I'm just in that unfortunate 10% category. I did stir a gram of phenethylamine into a double espresso once and drank it with parnate and felt a not-unpleasant buzz for a couple of hours.
>
> I have read that increased catecholamine synthesis depresses serotonin levels, so perhaps one should augment with 5HTP as well. By that point, however, it's probably safer to use cocaine.
>
>
>A Gram of pea!! That would have caused a hypertensive crisis in some.
Posted by bulldog2 on January 15, 2010, at 16:28:01
In reply to Re: L-Tyrosine and Parnate, posted by bulldog2 on January 15, 2010, at 15:09:57
> > I think this is of some relevance:
> >
> > From Birkmayer W, Riederer P, Linauer W, Knoll
> > Journal of Neural Transmission. 1984: 59(1):81-7:
> >
> > "The antidepressive efficacy of 1-deprenyl (5-10 mg daily) plus 1-phenylalanine (250 mg/day) has been evaluated in 155 unipolar depressed patients. Both oral and intravenous administration showed beneficial effects in 90% of outpatients and 80.5% of inpatients. It is concluded that this combined treatment has a potent antidepressive action based on the accumulation of 1-phenylethylamine in the brain."
> >
> > If it works for selegiline, I would assume it would work for tranylcypromine. However, in my experience, neither DL-phenylalanine nor tyrosine has had much effect on my mood, but maybe I'm just in that unfortunate 10% category. I did stir a gram of phenethylamine into a double espresso once and drank it with parnate and felt a not-unpleasant buzz for a couple of hours.
> >
> > I have read that increased catecholamine synthesis depresses serotonin levels, so perhaps one should augment with 5HTP as well. By that point, however, it's probably safer to use cocaine.
> >
> >
> >
>
> A Gram of pea!! That would have caused a hypertensive crisis in some.Phenyalanine may up NE, DA and PEA. I think when you elevate one, than serotonin may go down. For some the higher NE, and DA may help depression and for others make it worse because of the lowered SE. Maybe a good whey protein powder will elevate all of them. I know for some ritalin plus parnate is a good combo but there is the risk of hypertensive crisis.For some parnate and nortriptyline is a good mix. Parnate goes one the ability to tamper with all your neurotransmitter levels.
Posted by inanimate peanut on January 16, 2010, at 0:22:02
In reply to Re: L-Tyrosine and Parnate, posted by bulldog2 on January 15, 2010, at 16:28:01
I have a good protein powder that I have 2 shakes a day with. I just know that many of the amino acids compete for transport across the blood-brain barrier and thought I would give tyrosine a leg up in the race by supplementing it more. The symptoms of my depression right now are more the dopamine/norepinephrine (lack motivation, lack pleasure) than the serotonin (crying, sadness). So, I think it might be worth giving tyrosine the leg up in the race for awhile to see what happens. I wish I knew what we be a good amount for that to not get everything out of whack but to just give it a little boost?
Posted by bulldog2 on January 16, 2010, at 8:41:31
In reply to Re: L-Tyrosine and Parnate, posted by inanimate peanut on January 16, 2010, at 0:22:02
> I have a good protein powder that I have 2 shakes a day with. I just know that many of the amino acids compete for transport across the blood-brain barrier and thought I would give tyrosine a leg up in the race by supplementing it more. The symptoms of my depression right now are more the dopamine/norepinephrine (lack motivation, lack pleasure) than the serotonin (crying, sadness). So, I think it might be worth giving tyrosine the leg up in the race for awhile to see what happens. I wish I knew what we be a good amount for that to not get everything out of whack but to just give it a little boost?
You might try with 50 mg for the sake of safety.
This is the end of the thread.
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