Posted by Charles Darwood on January 14, 2010, at 20:22:29
In reply to Re: L-Tyrosine and Parnate, posted by bulldog2 on January 14, 2010, at 17:27:26
I think this is of some relevance:
From Birkmayer W, Riederer P, Linauer W, Knoll
Journal of Neural Transmission. 1984: 59(1):81-7:"The antidepressive efficacy of 1-deprenyl (5-10 mg daily) plus 1-phenylalanine (250 mg/day) has been evaluated in 155 unipolar depressed patients. Both oral and intravenous administration showed beneficial effects in 90% of outpatients and 80.5% of inpatients. It is concluded that this combined treatment has a potent antidepressive action based on the accumulation of 1-phenylethylamine in the brain."
If it works for selegiline, I would assume it would work for tranylcypromine. However, in my experience, neither DL-phenylalanine nor tyrosine has had much effect on my mood, but maybe I'm just in that unfortunate 10% category. I did stir a gram of phenethylamine into a double espresso once and drank it with parnate and felt a not-unpleasant buzz for a couple of hours.
I have read that increased catecholamine synthesis depresses serotonin levels, so perhaps one should augment with 5HTP as well. By that point, however, it's probably safer to use cocaine.
poster:Charles Darwood
thread:932371
URL: http://www.dr-bob.org/babble/20100113/msgs/933683.html