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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 13 of 13. This is the beginning of the thread.
Posted by ben on July 18, 2009, at 4:50:58
Does anyone has experience in augmenting Venlafaxine with Trazodone. Not because of sleep problems- because of lack of efficacy of Venlafaxine.
Posted by SLS on July 18, 2009, at 6:14:00
In reply to Venlafaxine and Trazodone a good combo, posted by ben on July 18, 2009, at 4:50:58
> Does anyone has experience in augmenting Venlafaxine with Trazodone. Not because of sleep problems- because of lack of efficacy of Venlafaxine.
I don't remember seeing anyone use trazodone to augment other antidepressants in the hopes of producing a therapeutic synergy.
Trazodone is primarily an antagonist of 5-HT1a and 5-HT2a serotonin receptors (although it does inhibit its reuptake to an extent.
It might work. Perhaps your doctor has had a good experience with the combination. Other drugs to combine with Effexor include Wellbutrin, nortriptyline, and Remeron.
I tried high dosages of trazodone when it was first marketed in 1982. I didn't like the way I felt on it, and I did not experience an antidepressant effect. I have not tried nefazodone, though.
- Scott
Posted by bleauberry on July 18, 2009, at 11:46:55
In reply to Venlafaxine and Trazodone a good combo, posted by ben on July 18, 2009, at 4:50:58
In my opinion Traz is a poor choice. Not to say it couldn't work, it just has very low odds compared to other options. I would put its odds at near zero.
SLS mentioned nortriptyline. That was my number one pick.
I personally don't like wellbutrin so I have a hard time supporting it, but in reality a fair percentage of people do quite well with it.
Effexor+Nortriptyline.
Effexor+Desipramine.
Effexor+Amitriptyline (if you are looking for the kind of knockout sedation that Traz has but want some antidepressant ummph at the same time)
Effexor+Wellbutrin.
Effexor+Zyprexa.
Effexor+Abilify.Of the above, my top pick would be the first one.
Posted by SLS on July 18, 2009, at 12:02:48
In reply to Re: Venlafaxine and Trazodone a good combo, posted by bleauberry on July 18, 2009, at 11:46:55
Hi BB.
Have you ever seen anyone respond to Effexor + Remeron?
I haven't, although almost no one here has tried it to the best of my recollection.
- Scott
Posted by Phillipa on July 18, 2009, at 12:46:25
In reply to Re: Venlafaxine and Trazodone a good combo » bleauberry, posted by SLS on July 18, 2009, at 12:02:48
Isn't that the California Rocket Fuel combo? Phillipa
Posted by SLS on July 18, 2009, at 14:11:36
In reply to Re: Venlafaxine and Trazodone a good combo » SLS, posted by Phillipa on July 18, 2009, at 12:46:25
> Isn't that the California Rocket Fuel combo? Phillipa
Yes, but I'm still waiting to see a successful launch.
- Scott
Posted by bulldog2 on July 18, 2009, at 14:19:21
In reply to Venlafaxine and Trazodone a good combo, posted by ben on July 18, 2009, at 4:50:58
> Does anyone has experience in augmenting Venlafaxine with Trazodone. Not because of sleep problems- because of lack of efficacy of Venlafaxine.
Ritalin sometimes blends well with an ad. Also if your p-doc is a maverick low dose oxycontin (40mg) might give it a good boost.
I'm currently on ritalin (40 mg), neurontin (2400mg) percocet (10 mg 4 times a day.) The acetimoniphen is low at 325 mg a pill but will probably be switched to oxycontin which is pure oxycodone. Have not upped my dose on anything. The euphoria effect of the percocet is gone but the ad effect is still good. Rule is don't chase the euphoria or your dose will escalate.
Posted by bulldog2 on July 18, 2009, at 15:29:11
In reply to Re: Venlafaxine and Trazodone a good combo, posted by bulldog2 on July 18, 2009, at 14:19:21
> > Does anyone has experience in augmenting Venlafaxine with Trazodone. Not because of sleep problems- because of lack of efficacy of Venlafaxine.
>
> Ritalin sometimes blends well with an ad. Also if your p-doc is a maverick low dose oxycontin (40mg) might give it a good boost.
>
> I'm currently on ritalin (40 mg), neurontin (2400mg) percocet (10 mg 4 times a day.) The acetimoniphen is low at 325 mg a pill but will probably be switched to oxycontin which is pure oxycodone. Have not upped my dose on anything. The euphoria effect of the percocet is gone but the ad effect is still good. Rule is don't chase the euphoria or your dose will escalate.sorry I failed to mention that I am on parnate (40mg). This combo is the best I have had in over 45 years. I feel very spiritual and I am at one with all meet. When I meet strangers at petsmart we talk and feel so much love and compassion for each others and our beloved dogs.Some in here don't treat their dogs thyroid conditions which saddens me. They know who they are.
This combo is used by my p-doc who I feel is a genious and mixes these magic chemicals like a great chef. Good luck to all!! Oh and please take note of generics if they are used. If your mood changes see if the generic is different.Please all smell and taste the fine coffee. Embrace life.
Posted by bleauberry on July 18, 2009, at 21:33:12
In reply to Re: Venlafaxine and Trazodone a good combo » bleauberry, posted by SLS on July 18, 2009, at 12:02:48
> Hi BB.
>
> Have you ever seen anyone respond to Effexor + Remeron?
>
> I haven't, although almost no one here has tried it to the best of my recollection.
>
>
> - ScottHi Scott, yes I have. Dang, the word recall thing has really got me at the moment and I can't remember the person's name. The person was a regular here many years ago. Other than that, I can't think of anyone else.
Posted by Phillipa on July 18, 2009, at 21:39:35
In reply to Re: Venlafaxine and Trazodone a good combo, posted by bulldog2 on July 18, 2009, at 15:29:11
Bulldog you don't sound quite right sure you're okay? Concerned about those meds and those feelings and the reference to trazadone, remeron and effexor? Phillipa
Posted by chumbawumba on July 19, 2009, at 1:28:10
In reply to Venlafaxine and Trazodone a good combo, posted by ben on July 18, 2009, at 4:50:58
I tried the combination of Effexor and Remeron, as well as Effexor + Remeron + Wellbutrin. And yes it is rocket fuel at first. But then it pooped out. This "poop out" phenomenon for me has been quite the b-i-t-c-h. The Remeron also gave me an incredible appetite for sweets (Hostess snack cakes). But for sleep, it was second only to Seroquel. No negotiation, you are going to sleep, 30-60 minutes after dosing with Remeron.
Posted by ben on July 20, 2009, at 9:45:43
In reply to Re: Venlafaxine and Trazodone a good combo, posted by chumbawumba on July 19, 2009, at 1:28:10
Please read the following message:
http://www.dr-bob.org/babble/20090709/msgs/907071.html
I dont know if it was the Trazodone which stopped working when Remeron was added or if it was the TCA which was reduced. Sureley there was an augmentation of the TCA or the Trazodone when Effexor was added a few days later.
Posted by linkadge on July 21, 2009, at 18:04:25
In reply to Re: Venlafaxine and Trazodone a good combo, posted by ben on July 20, 2009, at 9:45:43
While it is true that trazodone is rarely used by itself, it can be useful as an adjunct to other meds.
5-ht2 antagonists augment the clinical activity of SSRI's. Trazodone can improve sleep and may help reduce anxiety associated with SSRI's. I remember feeling better on celexa + trazodone than celexa alone. I had a wider range of emotions and less cognative disturbance.
Linkadge
This is the end of the thread.
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