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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by sowhysosad on July 14, 2009, at 11:05:51
I recently had a meal rich in Omega-3 which seemed to have a calming and mood-enhancing effect, and also mitigated fluoxetine startup side effects.
From what I've read elsewhere here I'm theorising that the Omega-3 may have had an effect on kindling and/or glutamate function.
Does anyone know how Omega-3 affects glutamate function? I've been unable to find any information.
Posted by Phillipa on July 14, 2009, at 11:50:35
In reply to Omega-3, glutamate function and kindling, posted by sowhysosad on July 14, 2009, at 11:05:51
So your're saying that a meal rich in Omega 3's helped prozac? What would happen if you supplemented with them? Glutamine I've always been confused about. I'm assuming you'll googled omega 3 and glutamine function? I probably will and will wait to see the many brilliant people on babble answer to question. Thanks Phillipa
Posted by Phillipa on July 14, 2009, at 12:26:26
In reply to Re: Omega-3, glutamate function and kindling » sowhysosad, posted by Phillipa on July 14, 2009, at 11:50:35
Only thing I found and it's a promotion for samee but lots of nutritional stuff. Phillipa
http://www.holisticonline.com/remedies/Depression/dep_nutrition2.htm
Posted by sowhysosad on July 14, 2009, at 12:28:36
In reply to Re: Omega-3, glutamate function and kindling » sowhysosad, posted by Phillipa on July 14, 2009, at 11:50:35
From what I've read here, glutamate is an excitory neurotransmitter.
Some posters theorise it might be the culprit when some of us have unpleasant reactions after returning to meds we previously tolerated - like over-stimulation, anxiety, nervousness, panic and racing thoughts.
I also gleaned from Babble that a certain high-profile doc (Stoll?) recommends Omega-3 for illnesses where kindling is implicated - like certain types of bipolar.
So I'm wondering if the Omega-3 somehow smoothed over the Prozac side effects and improved my mood by somehow altering glutamate function. If so, I'm gonna get me some supplements and give it a go!
I did extensively google, Phillipa, but couldn't find any useful information.
> So your're saying that a meal rich in Omega 3's helped prozac? What would happen if you supplemented with them? Glutamine I've always been confused about. I'm assuming you'll googled omega 3 and glutamine function? I probably will and will wait to see the many brilliant people on babble answer to question. Thanks Phillipa
Posted by sowhysosad on July 14, 2009, at 12:37:01
In reply to Re: Omega-3, glutamate function and kindling, posted by Phillipa on July 14, 2009, at 12:26:26
Thanks Phillipa!
I'll have a look.
> Only thing I found and it's a promotion for samee but lots of nutritional stuff. Phillipa
>
> http://www.holisticonline.com/remedies/Depression/dep_nutrition2.htm
Posted by Phillipa on July 14, 2009, at 13:05:52
In reply to Re: Omega-3, glutamate function and kindling, posted by sowhysosad on July 14, 2009, at 12:37:01
Well tried. Love Phillipa hope someone with more knowledge than me answers.
Posted by sam K on July 14, 2009, at 16:39:19
In reply to Re: Omega-3, glutamate function and kindling, posted by sowhysosad on July 14, 2009, at 12:28:36
do it, get some supplements. Ive been taking some lately and I feel better about myself and in general. I'm starting to believe more in supplements.
I recommend antioxidants, I take pomegranate extract just because I believe they are extremely healthy for me. But you can take reservatrol, which is a antioxidant in grapes thats really good for ageing, skin, probably brain a bit, and body overall.
Yea and omegas, whatever amount works for you. Some think more EPA is better for mood. Idk I havnt tried it yet.
Acetyl L carnitine is pretty good for some stimulation and is pretty good for memory in my experience.
o yea and obivously a multivitamin. And maybe some Vitamin D because they can help with depressed feelings I think.
Posted by sowhysosad on July 14, 2009, at 16:47:12
In reply to Re: Omega-3, glutamate function and kindling, posted by sam K on July 14, 2009, at 16:39:19
Thanks for the recommendation Sam!
I recall reading here that reservatrol also dampens glutamate function somehow, so it might be doubly useful.
> do it, get some supplements. Ive been taking some lately and I feel better about myself and in general. I'm starting to believe more in supplements.
> I recommend antioxidants, I take pomegranate extract just because I believe they are extremely healthy for me. But you can take reservatrol, which is a antioxidant in grapes thats really good for ageing, skin, probably brain a bit, and body overall.
> Yea and omegas, whatever amount works for you. Some think more EPA is better for mood. Idk I havnt tried it yet.
> Acetyl L carnitine is pretty good for some stimulation and is pretty good for memory in my experience.
> o yea and obivously a multivitamin. And maybe some Vitamin D because they can help with depressed feelings I think.
Posted by linkadge on July 15, 2009, at 17:32:15
In reply to Re: Omega-3, glutamate function and kindling, posted by sam K on July 14, 2009, at 16:39:19
Omega-3 inhibits PKC function which will indirectly supress glutamatergic function.
Linkadge
Posted by sowhysosad on July 16, 2009, at 5:55:02
In reply to Re: Omega-3, glutamate function and kindling, posted by linkadge on July 15, 2009, at 17:32:15
Thanks Linkadge.
I believe over-enthusiastic glutamatergic function may be causing anxiety, racing thoughts, rumination and lability of mood.
The symptoms seem to kick in after sucrose-rich meals and nicotine in particular, and calm down after alcohol or Omega-3-rich meals. This all points to glutamate function.
I'm at the 2-week mark with fluoxetine, which should eventually dampen glutamate release, but in the meantime I'm going to try Omega-3, cyanocobalamin or phosphatidylserine.
> Omega-3 inhibits PKC function which will indirectly supress glutamatergic function.
>
> Linkadge
Posted by linkadge on July 16, 2009, at 21:20:03
In reply to Sypmtoms of over-active gluamate function » linkadge, posted by sowhysosad on July 16, 2009, at 5:55:02
>The symptoms seem to kick in after sucrose-rich >meals and nicotine in particular, and calm down >after alcohol or Omega-3-rich meals. This all >points to glutamate function.
Possibly. Glutamate release is really the end stage of a number of possible upstream causes of neuronal hyperactivity.
>I'm at the 2-week mark with fluoxetine, which >should eventually dampen glutamate release, but >in the meantime I'm going to try Omega-3, >cyanocobalamin or phosphatidylserine.
SSRI's do not necessarily display consistent glutamate reducing activity. They can increase glutamate function in certain situations. Fluoxetine, for instance, has an inhibitory effect on glutamate reuptake.
Linkadge
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