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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 13 of 13. This is the beginning of the thread.
Posted by SLS on March 22, 2009, at 8:00:41
Vilazodone:
http://www.pgxhealth.com/about/vilazodone.cfm
We might finally get a 5-HT1a partial agonist that doesn't block dopamine receptors. Vilazodone also acts as a SSRI.
I'll be curious to see if vilazodone also proves useful in treating anxiety disorders.
- Scott
Posted by dcruik518 on March 22, 2009, at 9:18:52
In reply to Vilazodone - SSRI + 5HT1a partial agonist, posted by SLS on March 22, 2009, at 8:00:41
Hmm... sounds interesting. Does it work similarly to Trazodone and Serzone? I know they have a dual serotonergic action as well, just can't remember what exactly it is. Do you know when it's expected to be released?
Posted by SLS on March 22, 2009, at 10:34:39
In reply to Re: Vilazodone - SSRI + 5HT1a partial agonist, posted by dcruik518 on March 22, 2009, at 9:18:52
> Hmm... sounds interesting. Does it work similarly to Trazodone and Serzone? I know they have a dual serotonergic action as well, just can't remember what exactly it is. Do you know when it's expected to be released?
Actually, the drug is similar to gepirone, an investigative drug that has failed to be approved by the FDA. I believe that the reason buspirone can act as such a good augmenter of antidepressanats is because of its ability to act as a partial agonist (stimulator) of 5-HT1a receptors.
The article said that the drug company will submit vilazodone for approval later this year.
- Scott
Posted by Phillipa on March 22, 2009, at 12:40:03
In reply to Re: Vilazodone - SSRI + 5HT1a partial agonist » dcruik518, posted by SLS on March 22, 2009, at 10:34:39
Scott are you considering trying it or just educating? It's said SSRI's help anxiety but they never have with me would it be similar to that? And how are you doing? Love Phillipa
Posted by NickCave on March 22, 2009, at 15:44:41
In reply to Re: Vilazodone - SSRI + 5HT1a partial agonist » SLS, posted by Phillipa on March 22, 2009, at 12:40:03
I am very much looking forward to vilazodone. I wish they would have approved gepirone, as I think it would have been a great add-on med. It doesn't appear to have sexual side-effects - this would be a godsend for many of us. Fingers crossed!
Posted by iforgotmypassword on March 23, 2009, at 22:00:57
In reply to Vilazodone - SSRI + 5HT1a partial agonist, posted by SLS on March 22, 2009, at 8:00:41
it seems that it may only have 5-ht1a effects in vitro. its lack of effect on extracellular dopamine and noradrenaline is not shared by 5-ht1a partial agonist monotherapy, or when augmenting an ssri.
Posted by SLS on March 24, 2009, at 7:21:03
In reply to may just be another ssri, posted by iforgotmypassword on March 23, 2009, at 22:00:57
> it seems that it may only have 5-ht1a effects in vitro. its lack of effect on extracellular dopamine and noradrenaline is not shared by 5-ht1a partial agonist monotherapy, or when augmenting an ssri.
Which 5-HT1a partial agonists DO increase extracellular catecholamine concentrations via that mechanism?
- Scott
Posted by SLS on March 24, 2009, at 7:29:40
In reply to Re: may just be another ssri » iforgotmypassword, posted by SLS on March 24, 2009, at 7:21:03
> > it seems that it may only have 5-ht1a effects in vitro. its lack of effect on extracellular dopamine and noradrenaline is not shared by 5-ht1a partial agonist monotherapy, or when augmenting an ssri.
>
> Which 5-HT1a partial agonists DO increase extracellular catecholamine concentrations via that mechanism?Take a look at this:
Pretty exciting.
- Scott
Posted by iforgotmypassword on March 25, 2009, at 18:48:27
In reply to Re: may just be another ssri, posted by SLS on March 24, 2009, at 7:29:40
that article i will have to try to read again, but unfortunately i think it's beyond my level of comprehension.
this other article:
http://www.ncbi.nlm.nih.gov/pubmed/15740724
according to google, this article apparently contains this phrase: "The effects of vilazodone on extracellular dopamine and noradrenaline also do not indicate agonist activity at 5-HT1A receptors."
unfortunately i do no have the full-text.
Posted by SLS on March 25, 2009, at 21:07:14
In reply to Re: may just be another ssri » SLS, posted by iforgotmypassword on March 25, 2009, at 18:48:27
> that article i will have to try to read again, but unfortunately i think it's beyond my level of comprehension.
>
> this other article:
>
> http://www.ncbi.nlm.nih.gov/pubmed/15740724
>
> according to google, this article apparently contains this phrase: "The effects of vilazodone on extracellular dopamine and noradrenaline also do not indicate agonist activity at 5-HT1A receptors."
Wow. That's some pretty big news.As was said, it is too bad that gepirone was shot down by the FDA. There is a drug called flesinoxan that is a partial agonist at 5-HT1a receptors. I like this drug because, unlike gepirone, it is not metabolized into a NE alpha-2 receptor antagonist. Two such antagonists made my depression worse.
- Scott
Posted by kenny6 on March 26, 2009, at 20:55:42
In reply to Re: may just be another ssri » iforgotmypassword, posted by SLS on March 25, 2009, at 21:07:14
ALthough Pubmed is very reliable, there are so many contradicting articles on there. This thread got me looking at the articles I have bookmarked, and I think this may be the one of greatest importance.
Posted by desolationrower on April 15, 2009, at 2:03:08
In reply to Re: may just be another ssri, posted by SLS on March 24, 2009, at 7:29:40
> > > it seems that it may only have 5-ht1a effects in vitro. its lack of effect on extracellular dopamine and noradrenaline is not shared by 5-ht1a partial agonist monotherapy, or when augmenting an ssri.
> >
> > Which 5-HT1a partial agonists DO increase extracellular catecholamine concentrations via that mechanism?
>
> Take a look at this:
>
> http://www.ncbi.nlm.nih.gov/pubmed/18801415?ordinalpos=9&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
>
> Pretty exciting.
>
>
> - Scotti've had this study open in a tab in my browser for a while now, and haven't really been able to process it. i think it is pfc 5ht1a->inhibition of gabaB->glutamatergic efferents to VTA->NMDA activation->DA neurone burst activity
-d/r
Posted by bearfan on November 16, 2009, at 17:36:58
In reply to Vilazodone - SSRI + 5HT1a partial agonist, posted by SLS on March 22, 2009, at 8:00:41
Note Vilazodone is NOT the same as Valdoxan (or Agomelatine, the one that works on melatonin). Apparently Vilazodone had very high HAMD scores in trials and very little sexual disruptions.
This is the end of the thread.
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