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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 19 of 19. This is the beginning of the thread.
Posted by SLS on August 2, 2008, at 5:29:45
N-Acetyl Cysteine (NAC) for bipolar depression:
- Scott
Posted by Maximus on August 2, 2008, at 13:44:22
In reply to N-Acetyl Cysteine (NAC) for bipolar depression, posted by SLS on August 2, 2008, at 5:29:45
> N-Acetyl Cysteine (NAC) for bipolar depression:
>
> http://www.ncbi.nlm.nih.gov/pubmed/18534556?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
>
>
> - ScottScott,
Do you know if this stuff is available in Canada? I will look for it...
Max.
Posted by SLS on August 2, 2008, at 16:17:31
In reply to Re: N-Acetyl Cysteine (NAC) for bipolar depression » SLS, posted by Maximus on August 2, 2008, at 13:44:22
> > N-Acetyl Cysteine (NAC) for bipolar depression:
> >
> > http://www.ncbi.nlm.nih.gov/pubmed/18534556?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
> >> Do you know if this stuff is available in Canada? I will look for it...
I am not sure about Canada, but NAC is sold here as a food supplement to be found in vitamin stores. I bought mine from Vitamin Shoppe. I paid $23 for 600mg x 150. I take 1800mg/day in divided doses.
Be sure to understand that NAC can take a few months to show results - similar to Deplin.
- Scott
Posted by bleauberry on August 2, 2008, at 19:42:17
In reply to N-Acetyl Cysteine (NAC) for bipolar depression, posted by SLS on August 2, 2008, at 5:29:45
Hi Scott,
Any theories as to how NAC works? To the best of my knowledge glutathione is the major player in detoxification of environmental or biological pollutants/toxins. I wonder if that is the mechanism by which it works...that is, removing toxins that are clogging receptors, messing up immune systems, messing up neurtransmitters, confusing genes, whatever. Or is there something else? Any ideas?
Posted by SLS on August 3, 2008, at 5:18:24
In reply to Re: N-Acetyl Cysteine (NAC) for bipolar depression » SLS, posted by bleauberry on August 2, 2008, at 19:42:17
Hi BB.
> Any theories as to how NAC works?Yours look pretty good.
> To the best of my knowledge glutathione is the major player in detoxification of environmental or biological pollutants/toxins. I wonder if that is the mechanism by which it works...that is, removing toxins that are clogging receptors, messing up immune systems, messing up neurtransmitters, confusing genes, whatever. Or is there something else? Any ideas?
One other site at which glutathione uptake is important is in the mitochondria. Mitochondria cannot manufacture glutathione on their own, so they are dependent on the presence of glutathione in the cytosol. I have heard several theories regarding the etiology of depression implicating the mitochondria, so maybe there is something to it.
- Scott
Posted by Phillipa on August 3, 2008, at 12:26:37
In reply to Re: N-Acetyl Cysteine (NAC) for bipolar depression » Maximus, posted by SLS on August 2, 2008, at 16:17:31
Vitamin Shoppe is online too. I get notification from them almost daily via e-mail. Google it Maximus. Phillipa
Posted by Maximus on August 3, 2008, at 14:17:39
In reply to Re: N-Acetyl Cysteine (NAC) for bipolar depression » Maximus, posted by SLS on August 2, 2008, at 16:17:31
> > > N-Acetyl Cysteine (NAC) for bipolar depression:
> > >
> > > http://www.ncbi.nlm.nih.gov/pubmed/18534556?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
> > >
>
> > Do you know if this stuff is available in Canada? I will look for it...
>
> I am not sure about Canada, but NAC is sold here as a food supplement to be found in vitamin stores. I bought mine from Vitamin Shoppe. I paid $23 for 600mg x 150. I take 1800mg/day in divided doses.
>
> Be sure to understand that NAC can take a few months to show results - similar to Deplin.
>
>
> - Scott
Thanks for your tips Scott.Well, we know two things about NAC:
1- Both depression and bipolar disorder are complicated by glutathione depletion.
"http://www.journals.elsevierhealth.com/periodicals/bps/article/S0006-3223(08)00500-3/abstract"
2- And the other one: N-Acetyl Cysteine is a Glutamate-Modulating Agent.
"http://linkinghub.elsevier.com/retrieve/pii/S0006322306015101"
Unfortunately, here in Canada, this stuff is not largely available.
Max.
Posted by Larry Hoover on August 3, 2008, at 21:21:50
In reply to Re: N-Acetyl Cysteine (NAC) for bipolar depression, posted by Maximus on August 3, 2008, at 14:17:39
> Unfortunately, here in Canada, this stuff is not largely available.
>
> Max.You can certainly mail-order/internet-order it. It's not restricted from entry into Canada, provided you only order a 3-month supply of it. Or, if you're anywhere near a border crossing, you can pick some up in a U.S. Walmart or whatever.
NAC rejuvenates existing but spent glutathione, serves as a precursor for glutathione synthesis, and is a moderately active antioxidant in its own right.
Lar
Posted by chiron on August 3, 2008, at 21:24:35
In reply to Re: N-Acetyl Cysteine (NAC) for bipolar depression, posted by Maximus on August 3, 2008, at 14:17:39
A new pdoc didn't want to mess w/ my current regime but just add NAC & gave me some info.
"Individuals w/ these major psychiatric disorders have been found to be deficient in some of the most important intra-cellular anti-oxidants that protect the cell."
He also suggested taking it w/ ALA.
Posted by Sigismund on August 4, 2008, at 4:53:18
In reply to Re: N-Acetyl Cysteine (NAC) for bipolar depression, posted by chiron on August 3, 2008, at 21:24:35
I have read it is important to take twice the quantity of Vit C with NAC, to prevent it becoming a pro-oxidant.
Posted by Marty on August 4, 2008, at 13:22:14
In reply to Re: N-Acetyl Cysteine (NAC) for bipolar depression, posted by Sigismund on August 4, 2008, at 4:53:18
> I have read it is important to take twice the quantity of Vit C with NAC, to prevent it becoming a pro-oxidant.
---
Maybe it's prescribed when taken as an antioxydative supplement but I'm not sure it applies for BP disorder: The NAC dosage used in the study is 1g BID and so you would took 4g/day of Vitamin C which begins to be a dopaminergic dose... Not sure what it means espcially for BP1./\/\arty
Posted by chiron on August 5, 2008, at 23:21:11
In reply to Re: N-Acetyl Cysteine (NAC) for bipolar depression, posted by Sigismund on August 4, 2008, at 4:53:18
> I have read it is important to take twice the quantity of Vit C with NAC, to prevent it becoming a pro-oxidant.
My doc didn't mention Vit C. So I did a search on NAC & Vit C.
2001: "This acute human inflammatory model strongly suggests that vitamin C and NAC supplementation immediately post-injury, transiently increases tissue damage and oxidative stress."I also found some links that suggest taking it w/ Vitamin C.
"When taking L-cysteine, N-acetyl-cysteine, or glutathione, it is recommended that three times as much vitamin C should be taken at the same time to prevent these amino acids from being oxidized in the body."I give up.
That was the only recommendation the new pdoc could give me after my previous pdoc gave up on any med changes or new trials.
Posted by SLS on August 6, 2008, at 5:16:10
In reply to Re: N-Acetyl Cysteine (NAC) for bipolar depression » Sigismund, posted by chiron on August 5, 2008, at 23:21:11
Hi.
http://news.ufl.edu/2001/09/26/vitiminc/
Vitamin C isnt bad, and neither is NAC, but by some mechanism in this situation there were some pro-oxidant effects of supplementation,
People should limit their vitamin C intake until we know more,
"Because vitamin C and NAC in the body appear to react most negatively with iron, Leeuwenburgh said, those with inflammatory diseases and those who take more than the recommended daily allowance of iron should be particularly vigilant about limiting their vitamin C and NAC intake."
This pertains to muscle injury, but still. However, inflammation in the brain is a trait of depressive illness.
What do you guys make of this?
Where can I find material regarding the necessity to take vitamin-C along with NAC?
Thanks.
- Scott
Posted by Phillipa on August 6, 2008, at 19:45:55
In reply to Re: N-Acetyl Cysteine (NAC) for bipolar depression, posted by SLS on August 6, 2008, at 5:16:10
Scott I take 2000 mg a day of C this could be hurting my arthritis and thyroid? Love Phillipa
Posted by SLS on August 6, 2008, at 20:15:22
In reply to Re: N-Acetyl Cysteine (NAC) for bipolar depression » SLS, posted by Phillipa on August 6, 2008, at 19:45:55
> Scott I take 2000 mg a day of C this could be hurting my arthritis and thyroid? Love Phillipa
I'm not sure. I'll see what I can find out.
- Scott
Posted by Phillipa on August 6, 2008, at 20:30:19
In reply to Re: N-Acetyl Cysteine (NAC) for bipolar depression » Phillipa, posted by SLS on August 6, 2008, at 20:15:22
Scott what would I do without you. You listen. Wish you were a pdoc here. Love Phillipa
Posted by Adam_E on August 12, 2008, at 17:25:37
In reply to Re: N-Acetyl Cysteine (NAC) for bipolar depression » SLS, posted by Phillipa on August 6, 2008, at 20:30:19
> Scott what would I do without you.
You'd probably look it up yourself.
Posted by Phillipa on August 12, 2008, at 20:00:24
In reply to Re: N-Acetyl Cysteine (NAC) for bipolar depression, posted by Adam_E on August 12, 2008, at 17:25:37
I trust Scott explicitly and can't trust everything on the internet. He's a wonderful person. Phillipa
Posted by Marty on August 12, 2008, at 20:43:39
In reply to Re: N-Acetyl Cysteine (NAC) for bipolar depression, posted by Adam_E on August 12, 2008, at 17:25:37
> > Scott what would I do without you.
>
> You'd probably look it up yourself.
---
Your point being ?/\/\arty
This is the end of the thread.
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