![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 13 of 13. This is the beginning of the thread.
Posted by Phillipa on August 1, 2008, at 0:25:15
She also said that soon seroquel would officially be approved for anxiety. Anyone know anything about this? Love Phillipa
Posted by yxibow on August 1, 2008, at 2:50:21
In reply to Also Pdoc Said Seroquel Being Aproved For Anxiety, posted by Phillipa on August 1, 2008, at 0:25:15
> She also said that soon seroquel would officially be approved for anxiety. Anyone know anything about this? Love Phillipa
Posted by Phillipa on August 1, 2008, at 19:58:43
In reply to Re: Also Pdoc Said Seroquel Being Aproved For Anxi » Phillipa, posted by yxibow on August 1, 2008, at 2:50:21
Jay what about weight and diabetes? Love Jan
Posted by linkadge on August 1, 2008, at 20:03:01
In reply to Re: Also Pdoc Said Seroquel Being Aproved For Anxi » yxibow, posted by Phillipa on August 1, 2008, at 19:58:43
I don't know if this is such a good idea. GAD is generally a chronic disorder. The doses used for the GAD study are somewhat high, and weightgain/diabeties could be an issue with long term use.
Linkadge
Posted by Phillipa on August 1, 2008, at 20:55:53
In reply to Re: Also Pdoc Said Seroquel Being Aproved For Anxi, posted by linkadge on August 1, 2008, at 20:03:01
Link oh it's chronic for sure benzos more than half my life. No atypicals or typicals for me any ideas? Love Phillipa
Posted by yxibow on August 2, 2008, at 2:01:21
In reply to Re: Also Pdoc Said Seroquel Being Aproved For Anxi, posted by linkadge on August 1, 2008, at 20:03:01
> I don't know if this is such a good idea. GAD is generally a chronic disorder. The doses used for the GAD study are somewhat high, and weightgain/diabeties could be an issue with long term use.
>
> LinkadgeWell I agree its a problem, I take Seroquel off label more for a complex of complexes of anxiety and managing my weight has become a bit of a problem since there are obstacles for excercise that I can't begin to explain, they would be baffling.
However, not everyone who takes Seroquel will instantly gain large amounts of weight, and vice-versa for Zyprexa.
A way of coming up with a plan to manage it before it gets to a point is a good idea though. Cutting down one's input calories is one sure way of preventing it, but its rather hard I know personally because its very easy to reach for snacks.
As for its benefits for GAD, I would say its an individual situation but it probably should be something that should be used after other methods have been tried.
-- Jay
Posted by obsidian on August 2, 2008, at 8:33:13
In reply to Also Pdoc Said Seroquel Being Aproved For Anxiety, posted by Phillipa on August 1, 2008, at 0:25:15
well that's interesting since I already take it for anxiety
sometimes I really love this drug
but a lot of the time I really hate it
-the sedation, the weight gain
people will do a lot just to feel comfortable
Posted by Bob on August 2, 2008, at 15:14:49
In reply to Re: Also Pdoc Said Seroquel Being Aproved For Anxiety, posted by obsidian on August 2, 2008, at 8:33:13
> well that's interesting since I already take it for anxiety
>
> sometimes I really love this drug
>
> but a lot of the time I really hate it
> -the sedation, the weight gain
> people will do a lot just to feel comfortableDoes anyone know if Seroquel is any more or less likely to cause sedation or weight gain than Zyprexa? I thought Zyprexa was the king for both of those, although Seroquel might be more on the sedation side.
Posted by Phillipa on August 2, 2008, at 19:52:28
In reply to Re: Also Pdoc Said Seroquel Being Aproved For Anxiety » obsidian, posted by Bob on August 2, 2008, at 15:14:49
Isn't it kind of an antihistamine? Yes they need to solve the weight problems before I would take it as well as the diabetes as it runs in my family. Phillipa
Posted by linkadge on August 2, 2008, at 20:12:00
In reply to Re: Also Pdoc Said Seroquel Being Aproved For Anxi » linkadge, posted by yxibow on August 2, 2008, at 2:01:21
>However, not everyone who takes Seroquel will >instantly gain large amounts of weight, and vice->versa for Zyprexa.
True, but research is now suggesting that the drugs can induce metabolic changes in the absense of weight gain. Zyprexa, in particular, can screw with the pancreas in the absense of weight gain.
Its not the side effects with warning signs that I am worried about, its about people getting diabeties without any warning signs.
>A way of coming up with a plan to manage it >before it gets to a point is a good idea though. >Cutting down one's input calories is one sure >way of preventing it, but its rather hard I know >personally because its very easy to reach for >snacks.
Serquel made me feel so ickey without any change in appetite. I don't think that diet and exercise are necessarily going to combat these issues as again, the drug may be directly affecting pancreatic function in the absense of weight gain.
Thats not to say that diet and exercise aren't a good idea, theres just no proof that they do infact alter the neuroendocrine changes associted with these drugs.
>As for its benefits for GAD, I would say its an >individual situation but it probably should be >something that should be used after other >methods have been tried.
Yes, I agree. However it got an indication for GAD which may give the impression to doctors that the FDA concludes the risk/benifit ratio in GAD is favorable when it may not infact be. It may work for GAD, but theres so much more to consider.
Also, to be honest, seroquel XR may be more dangerous than regular seroquel. The IR version's shorter half life may allow the body to have a necessary period of drug absence. If the drug is in the body constantly it may wreak more havok.
For instance, in GAD with predominant insomnia (ie where it is essentially being used as a sleeping pill), the IR version is likely much safer and more effective, allowing an overal lower dosage and exposure timeframe.
Linkadge
Posted by yxibow on August 3, 2008, at 1:44:44
In reply to Re: Also Pdoc Said Seroquel Being Aproved For Anxi, posted by linkadge on August 2, 2008, at 20:12:00
> >However, not everyone who takes Seroquel will >instantly gain large amounts of weight, and vice->versa for Zyprexa.
>
> True, but research is now suggesting that the drugs can induce metabolic changes in the absense of weight gain. Zyprexa, in particular, can screw with the pancreas in the absense of weight gain.
>
> Its not the side effects with warning signs that I am worried about, its about people getting diabeties without any warning signs.
>
> >A way of coming up with a plan to manage it >before it gets to a point is a good idea though. >Cutting down one's input calories is one sure >way of preventing it, but its rather hard I know >personally because its very easy to reach for >snacks.
>
> Serquel made me feel so ickey without any change in appetite. I don't think that diet and exercise are necessarily going to combat these issues as again, the drug may be directly affecting pancreatic function in the absense of weight gain.
>
> Thats not to say that diet and exercise aren't a good idea, theres just no proof that they do infact alter the neuroendocrine changes associted with these drugs.
>
> >As for its benefits for GAD, I would say its an >individual situation but it probably should be >something that should be used after other >methods have been tried.
>
> Yes, I agree. However it got an indication for GAD which may give the impression to doctors that the FDA concludes the risk/benifit ratio in GAD is favorable when it may not infact be. It may work for GAD, but theres so much more to consider.
>
> Also, to be honest, seroquel XR may be more dangerous than regular seroquel. The IR version's shorter half life may allow the body to have a necessary period of drug absence. If the drug is in the body constantly it may wreak more havok.
>
> For instance, in GAD with predominant insomnia (ie where it is essentially being used as a sleeping pill), the IR version is likely much safer and more effective, allowing an overal lower dosage and exposure timeframe.
>
> Linkadge
XR hasn't really been dispensed much from what I've heard because its considered a patent extender and not particularly novel in schizophrenia. Its been already known in psychiatric circles that even though it has a short half life of 6 hours, its the plasma life that is more important and for almost all patients once a day Seroquel has been the norm.
-- Jay
Posted by Bob on August 3, 2008, at 14:28:10
In reply to Re: Also Pdoc Said Seroquel Being Aproved For Anxi » linkadge, posted by yxibow on August 3, 2008, at 1:44:44
> XR hasn't really been dispensed much from what I've heard because its considered a patent extender and not particularly novel in schizophrenia. Its been already known in psychiatric circles that even though it has a short half life of 6 hours, its the plasma life that is more important and for almost all patients once a day Seroquel has been the norm.
>
>
> -- Jay
What exactly is the difference between plasma life and elimination half-life? I always assumed they were one and the same. I can't find any info on how the drug is eliminated in terms of plasma life in the drug monographs. Am I missing something?
Posted by yxibow on August 4, 2008, at 0:06:42
In reply to Re: Also Pdoc Said Seroquel Being Aproved For Anxi » yxibow, posted by Bob on August 3, 2008, at 14:28:10
>
> > XR hasn't really been dispensed much from what I've heard because its considered a patent extender and not particularly novel in schizophrenia. Its been already known in psychiatric circles that even though it has a short half life of 6 hours, its the plasma life that is more important and for almost all patients once a day Seroquel has been the norm.
> >
> >
> > -- Jay
>
>
> What exactly is the difference between plasma life and elimination half-life? I always assumed they were one and the same. I can't find any info on how the drug is eliminated in terms of plasma life in the drug monographs. Am I missing something?Plasma life refers to the length an agent and its metabolites stay in your blood system and can be considerably longer than the drugs "half life".
Elimination half-life depends on genetic factors and where the drug is being eliminated, more often than not through the liver, but also through the kidney system.
Theoretically I suppose if no new drug was introduced into the system, the elimination half life (half lives are considered complete roughly 5 times after their length, give or take, its a rough estimate to a non-linear mathematical fomula) would determine the end of a drug in the body.
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.