Posted by yxibow on August 4, 2008, at 0:06:42
In reply to Re: Also Pdoc Said Seroquel Being Aproved For Anxi » yxibow, posted by Bob on August 3, 2008, at 14:28:10
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> > XR hasn't really been dispensed much from what I've heard because its considered a patent extender and not particularly novel in schizophrenia. Its been already known in psychiatric circles that even though it has a short half life of 6 hours, its the plasma life that is more important and for almost all patients once a day Seroquel has been the norm.
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> > -- Jay
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> What exactly is the difference between plasma life and elimination half-life? I always assumed they were one and the same. I can't find any info on how the drug is eliminated in terms of plasma life in the drug monographs. Am I missing something?Plasma life refers to the length an agent and its metabolites stay in your blood system and can be considerably longer than the drugs "half life".
Elimination half-life depends on genetic factors and where the drug is being eliminated, more often than not through the liver, but also through the kidney system.
Theoretically I suppose if no new drug was introduced into the system, the elimination half life (half lives are considered complete roughly 5 times after their length, give or take, its a rough estimate to a non-linear mathematical fomula) would determine the end of a drug in the body.
poster:yxibow
thread:843414
URL: http://www.dr-bob.org/babble/20080727/msgs/844038.html