Psycho-Babble Medication Thread 842638

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SAM-e metabolism - question for Larry and others

Posted by tarheelex on July 28, 2008, at 16:32:46

Hey guys

I have a fairly technical question that I'm hoping someone can answer. I have been taking SAM-e for about 3 months now with decent results. I'm sensitive to meds so I only take about 200 mgs once daily. It's not 100% effective but I much prefer SAM-e to synthetic antidepressants.

However, recently I've been experiencing a nonstop herpes outbreak that I can't seem to find a logical cause for. I've started to review in detail the supplements I take and the only one that seems to maybe be the guilty culprit is SAM-e. It seems as though the enzymatic pathway that metabolizes SAM-e is implicated for herpes outbreaks:

http://www.fasebj.org/cgi/reprint/04-2108fjev1.pdf

I'm not well-studied in these matters and could be interpreting the research incorrectly. But, I'm hoping someone here can either confirm or deny a possible link. The only other possible connection I can make is my recent re-entry into the gym after a protracted break due to severe IBS. Maybe the lactic acid release from the muscles is creating a good environment for the herpes virus.

Appreciate the thoughts!

Re: SAM-e metabolism - question for Larry and others » tarheelex

Posted by Larry Hoover on July 28, 2008, at 20:34:18

In reply to SAM-e metabolism - question for Larry and others, posted by tarheelex on July 28, 2008, at 16:32:46

Your suspicion is plausible, but there isn't enough information in the article for me to draw a firm conclusion. Given that the SAMe decarboxylase enzyme is essential to viral replication, supplying a ready source of SAMe would conceivably enhance the output of that particular enzyme, perhaps enhancing viral replication. Sorry.

Lar

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