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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by bleauberry on December 5, 2007, at 17:56:21
I tried Milnacipran 25mg first day. Doses in trials were usually 100mg to 200mg. Some have reported good effects at 50mg. Being supersensitive I was surprised I handled 25mg just fine. Maybe tiny bit of distant nausea and some restless sleep but that's it. Second day forward did 25mg twice a day. By day 3 it was already working. More energy, more talkative, more enjoyment of ordinary things. I was enthused with the promising start.
But by day 3 a side effect that happens in about 20% of clinical trial patients happened...inability to urinate. Oh my. I had to go so bad it was painful. It hurt. As I forced and waited, I finally got a few dribbles after a couple minutes of shear effort. This went on for a couple days and I had no choice but to throw in the towel. It was a pretty serious side effect.
Now back to glum and fatigue again.
Milnacipran is a serotonin and norepinephrine reuptake inhibitor with a balance of 1:3. Effexor has a balance of 30:1, cymbalta 9:1. Milnacipran is almost an equal balance, touted as having few side effects and being a clean version of a TCA. Too bad it isn't at USA pharmacies. Too bad it caused me dysuria!
Posted by Phillipa on December 6, 2007, at 0:03:37
In reply to Milnacipran worked good but..., posted by bleauberry on December 5, 2007, at 17:56:21
Blueberry are you going back on meds? Love Phillipa
Posted by clipper40 on December 7, 2007, at 2:50:50
In reply to Milnacipran worked good but..., posted by bleauberry on December 5, 2007, at 17:56:21
What a shame!!! Have you had that kind of side effect from any other noradrenergic meds? It sounds like a good medication though. Another one I wish we had access to in the U.S. I'm curious where you found those SE/NE ratios?
Posted by bleauberry on December 7, 2007, at 19:41:21
In reply to Re: Milnacipran worked good but... » bleauberry, posted by clipper40 on December 7, 2007, at 2:50:50
I'm curious where you found those SE/NE ratios?
>
>Sorry I don't have the exact locations. One was at pubmed.com. Another one was at biopsychiatry. I think I had typed in a google search "cymbalta versus effexor". And then got the info for milnacipran from the places that sell it, in addition to pubmed and biopsychiatry.
Posted by bleauberry on December 7, 2007, at 19:43:48
In reply to Milnacipran worked good but..., posted by bleauberry on December 5, 2007, at 17:56:21
Sure feels good to pee again! Nice. Sure wish there was a way to reverse a drug induced dysuria so as to avoid stopping the drug causing it. Even though I was only on milnacipran for under a week, I miss it. Good one. Doesn't feel anything at all like cymbalta or effexor.
Posted by bleauberry on December 7, 2007, at 19:57:09
In reply to Re: Milnacipran worked good but... » bleauberry, posted by Phillipa on December 6, 2007, at 0:03:37
> Blueberry are you going back on meds? Love Phillipa
Maybe. Maybe not. Am I up to sampling some? Yes. But if there is any immediate worsening of symptoms, that is a deal breaker. Intense side effects, deal breaker.
I am not looking to step back in time into the SSRI/antipsychotic/mood stabilizer/benzo arena. Been there done that. Once in a while, here and in real life, I see someone who is doing just great with those things. But for the most part, they seem to cause more current and future problems while not doing much of any help to write home about.
Posted by clipper40 on December 7, 2007, at 20:03:49
In reply to Re: Milnacipran worked good but... » clipper40, posted by bleauberry on December 7, 2007, at 19:41:21
Posted by Iansf on December 10, 2007, at 23:36:10
In reply to Milnacipran worked good but..., posted by bleauberry on December 5, 2007, at 17:56:21
There are meds that can help with urination, bethanecol being the most common. You might see if taking one of them along with milnacipran would eliminate the problem.
> I tried Milnacipran 25mg first day. Doses in trials were usually 100mg to 200mg. Some have reported good effects at 50mg. Being supersensitive I was surprised I handled 25mg just fine. Maybe tiny bit of distant nausea and some restless sleep but that's it. Second day forward did 25mg twice a day. By day 3 it was already working. More energy, more talkative, more enjoyment of ordinary things. I was enthused with the promising start.
>
> But by day 3 a side effect that happens in about 20% of clinical trial patients happened...inability to urinate. Oh my. I had to go so bad it was painful. It hurt. As I forced and waited, I finally got a few dribbles after a couple minutes of shear effort. This went on for a couple days and I had no choice but to throw in the towel. It was a pretty serious side effect.
>
> Now back to glum and fatigue again.
>
> Milnacipran is a serotonin and norepinephrine reuptake inhibitor with a balance of 1:3. Effexor has a balance of 30:1, cymbalta 9:1. Milnacipran is almost an equal balance, touted as having few side effects and being a clean version of a TCA. Too bad it isn't at USA pharmacies. Too bad it caused me dysuria!
Posted by maree on May 14, 2008, at 0:34:05
In reply to Re: Milnacipran worked good but... » bleauberry, posted by Iansf on December 10, 2007, at 23:36:10
So, where are you getting your Milnacipran? Is it brand name of IXEL?
I am in Australia, and we are pathetically slow to get new, effective, drugs on the market.
This is the end of the thread.
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