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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 13 of 13. This is the beginning of the thread.
Posted by SteelyDan on May 6, 2008, at 20:14:01
My pdoc put me on 60 mgs of Geodon combined with Prozac for TR Depresion. Can anybody explain to me how geodon works and how it might be effective in treating depression? Thanks.
-Dan
Posted by Jeroen on May 6, 2008, at 21:05:23
In reply to Can anyone please explain to me how Geodon works?, posted by SteelyDan on May 6, 2008, at 20:14:01
oh what are these doctors thinking, Prozac is an SSRI, and is activating already, this combining with geodon wich is also seriously activating is nooooooot good!
Posted by SteelyDan on May 6, 2008, at 21:27:37
In reply to Re: Can anyone please explain to me how Geodon works?, posted by Jeroen on May 6, 2008, at 21:05:23
> oh what are these doctors thinking, Prozac is an SSRI, and is activating already, this combining with geodon wich is also seriously activating is nooooooot good!
Well, studies have proven otherwise!
Posted by Jeroen on May 6, 2008, at 21:28:50
In reply to Re: Can anyone please explain to me how Geodon works? » Jeroen, posted by SteelyDan on May 6, 2008, at 21:27:37
studies also never revealed the truth, everybody is freaking lying about how they really feel :|
Posted by SteelyDan on May 6, 2008, at 21:31:19
In reply to Re: Can anyone please explain to me how Geodon works?, posted by Jeroen on May 6, 2008, at 21:28:50
> studies also never revealed the truth, everybody is freaking lying about how they really feel :|
whatever....
Posted by Jeroen on May 6, 2008, at 21:33:22
In reply to Re: Can anyone please explain to me how Geodon works? » Jeroen, posted by SteelyDan on May 6, 2008, at 21:31:19
ok, im not saying anything, but you might be right, just tell us how you feel ok with this combo, please ;)
Posted by SteelyDan on May 6, 2008, at 23:08:08
In reply to Re: Can anyone please explain to me how Geodon works?, posted by Jeroen on May 6, 2008, at 21:33:22
> ok, im not saying anything, but you might be right, just tell us how you feel ok with this combo, please ;)
>
>will do.
Posted by SteelyDan on May 7, 2008, at 13:55:24
In reply to Re: Can anyone please explain to me how Geodon works? » Jeroen, posted by SteelyDan on May 6, 2008, at 23:08:08
Jeroen,
I just wanted to tell you that I'm sorry Geodon was a terrible Drug for you causing TD, i'm truly sorry about that! But, please remember that it may be a good medicine for other people. All anti-psychotic meds can cause TD and that sucks, but the chances are slim. Were you on a high dose? Again, i'm very sorry that happened to you, and hopefully with time it will reverse.-Dan
Posted by Jeroen on May 7, 2008, at 13:56:17
In reply to For Jeroen » SteelyDan, posted by SteelyDan on May 7, 2008, at 13:55:24
it will not reverse, i was on lowest dosage 20 mg twice a day
Posted by bleauberry on May 7, 2008, at 17:20:28
In reply to Can anyone please explain to me how Geodon works?, posted by SteelyDan on May 6, 2008, at 20:14:01
Geodon is an antagonist of dopamine D2 and serotonin 5ht2 receptors, as well as other dopamine and serotonin receptors, adrenergic alpha-1 receptors and histimine. All of varying potencies.
The mechanism of this antipsychotic or any of them in depression is unknown, or hypothetical at best, though they have been shown to increase levels of neurotransmitters in the brain. Dopamine agonists can improve depression, but dopamine antagonists can also. So there is some mystery there. They can also make depression worse in some people. As with any drug, we just know that they have the potential to be helpful based on experiences of other people and the only way to know how they work for us is to try.
Posted by med_empowered on May 8, 2008, at 16:31:27
In reply to Can anyone please explain to me how Geodon works?, posted by SteelyDan on May 6, 2008, at 20:14:01
that Geodon is like an atypical antipsychotic with built in neurotransmitter reuptake inhibitor properties. So, its like taking an atypical dopamine antagonist and an antidepressant. I've seen some psychopharms say the reuptake inhibition is like that of Tofranil...I think the newish Tofranil, Tofranil-PM, has a website where you can go and see why its still Rx'd...it apparently has "balanced reuptake inhibition" of serotonin and (I think) norepinephrine (sp?). So in your case its like getting 2 antidepressants and an atypical antipsythcotic all in one.
I've always heard that antipsythotics were good for agitated depression, but now they're being used for all kindsa depression...maybe b/c of the serotonin antagonism of the atypicals? I dunno. Anyway, I hope it works for you.
Posted by SLS on May 11, 2008, at 6:27:12
In reply to Can anyone please explain to me how Geodon works?, posted by SteelyDan on May 6, 2008, at 20:14:01
> My pdoc put me on 60 mgs of Geodon combined with Prozac for TR Depresion. Can anybody explain to me how geodon works and how it might be effective in treating depression? Thanks.
>
> -DanHi Dan.
***********************************
DA2 antagonist ++
DA3 antagonist ++
5-HT1a agonist ++
5-HT1d antagonist
5-HT2a antagonist +++
NE reuptake inhibition
5-HT reuptake inhibition**********************************
Take your pick.
I don't think scientists know for sure how this drug works to relieve depression. It just does.
How does this information influence your decision-
making process?
- Scott
Posted by Forerunner on May 11, 2008, at 8:49:32
In reply to Re: Can anyone please explain to me how Geodon wor » SteelyDan, posted by SLS on May 11, 2008, at 6:27:12
> > My pdoc put me on 60 mgs of Geodon combined with Prozac for TR Depresion. Can anybody explain to me how geodon works and how it might be effective in treating depression? Thanks.
> >
> > -Dan
>
>
>
> Hi Dan.
>
> ***********************************
>
> DA2 antagonist ++
> DA3 antagonist ++
> 5-HT1a agonist ++
> 5-HT1d antagonist
> 5-HT2a antagonist +++
> NE reuptake inhibition
> 5-HT reuptake inhibition
>
> **********************************
>
> Take your pick.
>
> I don't think scientists know for sure how this drug works to relieve depression. It just does.
>
> How does this information influence your decision-
> making process?
>
>
> - ScottIt doesn't, i just like to know out of curiosity. Thanks.
-Dan
This is the end of the thread.
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