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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 15 of 15. This is the beginning of the thread.
Posted by Phillipa on January 27, 2008, at 12:25:25
Posted on neurotransmitter site and no response and seems to be some comfusion on this fact this is from official Deplin site. Seems it can affect a lot of mood stabalizers. I didn't include that here just the anemia stuff. Comments please Thanks Phillipa
What To Expect
Are there side effects with Deplin?
L-methylfolate was well tolerated in both short-term and long-term trials. Side effects did not differ from a sugar pill (placebo). Deplin® has not been associated with weight gain, sexual dysfunction or nausea.How do I take Deplin®?
For best results, you should take Deplin® exactly as prescribed by your doctor. For most people, Deplin is prescribed once a day, every day, with or without food. You should also fill your prescriptions ahead of time to avoid missing a dose.When will I feel an effect and what can I expect?
You may begin to feel better after taking Deplin for 1 to 2 weeks, but the full effect may take 4 to 6 weeks. You may feel an improvement in one or more of the following areas:14Drive
Initiative
Alertness
Concentration
Mood
Sociability
How long do I have to take it?
For some, depression can be an ongoing condition that may require long-term treatment. Your healthcare provider will track your progress and work with you to determine the right length of treatment. Do not stop taking Deplin without talking to your doctor.Will Deplin® affect other medications I might be taking?
Deplin® does not require dosing adjustments when taken together with most medications. Deplin® may lower the levels of the following anticonvulsants (mood stabilizers): carbamazepine, fosphenytoin, phenytoin, phenobarbital, primidone, valproic acid. If you are taking one of these medications, let your doctor know.What other safety information should be considered?
Deplin® may mask the diagnosis of pernicious anemia caused by a lack of B12. Deplin® will not cause pernicious anemia, but if you believe you may be anemic, consult with your doctor immediately.When would Deplin® not be right for me?
If you have a known hypersensitivity to folate or folic acid.
Posted by Phillipa on January 27, 2008, at 13:52:17
In reply to Deplin will not cause pernicious anemia, posted by Phillipa on January 27, 2008, at 12:25:25
Can't get anemia if bleeding is right around the corner for me. Does someone know for sure as therapist said not to believe everything on the internet. thanks again Phillipa
Posted by Jamal Spelling on January 27, 2008, at 14:11:18
In reply to Re: Am I right or wrong as surgery coming up?????, posted by Phillipa on January 27, 2008, at 13:52:17
You are right, Phillipa. Deplin does not *cause* anemia. If you have anemia, Deplin may *hide* some of the symptoms, while the anemia persists. That is why it might be worthwhile to take a vitamin B12 supplement if you intend using Deplin long term.
If you are concerned about using Deplin with your upcoming surgery, perhaps you might discuss this with your surgeon and/or anesthetist.
Posted by sunnydays on January 27, 2008, at 15:47:19
In reply to Re: Am I right or wrong as surgery coming up?????, posted by Phillipa on January 27, 2008, at 13:52:17
Ask your surgeon if he is concerned. If not, then you're fine.
sunnydays
Posted by Racer on January 27, 2008, at 17:25:36
In reply to Re: Am I right or wrong as surgery coming up?????, posted by Phillipa on January 27, 2008, at 13:52:17
> Does someone know for sure as therapist said not to believe everything on the internet.
That's very good advice from your therapist.
Have you considered that it applies to this site as well as any others?
Posted by Phillipa on January 27, 2008, at 20:23:49
In reply to Re: Am I right or wrong as surgery coming up????? » Phillipa, posted by Racer on January 27, 2008, at 17:25:36
Yes I listen and form my own opinions of what I read. So far the docs know nothing about Deplin but if you do not have low B12 you will not develop it on Deplin according to only reliable resourse at this time. Soon hopefully more will be known. Love Phillipa ps that is the deplin website so many places to poke around on it. See what you see. wwwdeplin.com.
Posted by Glydin on January 27, 2008, at 21:58:34
In reply to Re: Am I right or wrong as surgery coming up?????, posted by Phillipa on January 27, 2008, at 20:23:49
> website so many places to poke around on it. See what you see. wwwdeplin.com.
~~~ Maybe putting down the poking stick is a better plan?
Posted by Phillipa on January 28, 2008, at 12:25:53
In reply to Re: Am I right or wrong as surgery coming up????? » Phillipa, posted by Glydin on January 27, 2008, at 21:58:34
The pharmacies direct you to the site as they have no info other than on the prescribing info included in the presciption bag go to www.deplin.com. So seems in order to be informed the drug company since the docs have never heard of it is a good thing in this case. Phillipa
Posted by stargazer2 on January 28, 2008, at 17:59:51
In reply to Re: Am I right or wrong as surgery coming up????? » Glydin, posted by Phillipa on January 28, 2008, at 12:25:53
I was unimpressed with this website. It really jsut seems like it is to promote the sales of the product and doesn't have much in the way of research or anything else to support it's efficacy.
I think it may work for some but if your folic acid is normal I don't understand why you would need it anyway, unless you are deficient.
There's so many things out there that are touted to work in depression, such as fish oil, exercise, SJW, etc., that each of these products with perhaps the exception of exercise, could be patented and sold as a medical food or whatever they claim it is, and alot of money could be made from this.
Are there are studies on Deplin where the outcomes prove the benefit of combining it with AD's and in particular which AD's? I guess from what I have read on this website, I am not convinced that it has been studied to see how effective it is against a placebo.
Posted by Phillipa on January 28, 2008, at 18:53:07
In reply to Deplin.com, posted by stargazer2 on January 28, 2008, at 17:59:51
Stargazer I agree as they compare it to a sugar pill for side effects. The sad thing is the doctors don't seem to know a thing about it. So far nothing on this end. Phillipa
Posted by Jamal Spelling on January 29, 2008, at 12:36:06
In reply to Deplin.com, posted by stargazer2 on January 28, 2008, at 17:59:51
> I think it may work for some but if your folic acid is normal I don't understand why you would need it anyway, unless you are deficient.
Ignoring the fact that folic acid is not the same as methylfolate, it may be that depressed individuals have higher requirements of folic acid than the general population, or that depressed individuals may benefit from greater quantities of folic acid than the general population. Sort of like how menopausal women have higher requirements of calcium.
> There's so many things out there that are touted to work in depression, such as fish oil, exercise, SJW, etc., that each of these products with perhaps the exception of exercise, could be patented and sold as a medical food or whatever they claim it is, and alot of money could be made from this.Methylfolate itself is not patented, and cannot be patented, since it is a naturally occuring substance. Likewise fish oil and SJW cannot be patented. The specific process by which methylfolate is being synthesized (which is currently the only cost-effective method of synthesis) is what is patented.
Posted by bulldog2 on January 29, 2008, at 15:04:44
In reply to Re: Deplin.com, posted by Jamal Spelling on January 29, 2008, at 12:36:06
> > I think it may work for some but if your folic acid is normal I don't understand why you would need it anyway, unless you are deficient.
>
> Ignoring the fact that folic acid is not the same as methylfolate, it may be that depressed individuals have higher requirements of folic acid than the general population, or that depressed individuals may benefit from greater quantities of folic acid than the general population. Sort of like how menopausal women have higher requirements of calcium.
>
> > There's so many things out there that are touted to work in depression, such as fish oil, exercise, SJW, etc., that each of these products with perhaps the exception of exercise, could be patented and sold as a medical food or whatever they claim it is, and alot of money could be made from this.
>
> Methylfolate itself is not patented, and cannot be patented, since it is a naturally occuring substance. Likewise fish oil and SJW cannot be patented. The specific process by which methylfolate is being synthesized (which is currently the only cost-effective method of synthesis) is what is patented.They now have a prescription fish oil.
Posted by Phillipa on January 29, 2008, at 20:08:37
In reply to Re: Deplin.com, posted by bulldog2 on January 29, 2008, at 15:04:44
Really what's it called will goggle it later. Love Phillipa
Posted by Ron Hill on January 30, 2008, at 4:27:22
In reply to Deplin will not cause pernicious anemia, posted by Phillipa on January 27, 2008, at 12:25:25
Jan, et. al.
Jan, am I the one that has got you so confused on this issue? If so, I'm very sorry. That was certainly not my intent. You already get B12 shots, correct?
In any case, you are not going to get pernicious anaemia just by taking Deplin. All I've been trying to do is to alert people that are taking Deplin that they should also take methyl-B12. Patients taking L-methylfolate, or any other kind of folate, will somewhat reduce B12 levels unless the patients supplements with B12. HOWEVER, THAT DOES NOT MEAN YOU WILL GET PERNICIOUS ANAEMIA.
As you know, I take 7.5 mg/day of Deplin, and you can bet your boots that I take 3 mg/day of methyl-B12 and 50 mg/day of P-5-P with my Deplin. The neurochemistry and the published research make it a no-brainer. When taking a large amount of folate, supplementation of methyl-B12 is prudent.
Jan, in addition to Deplin, there are currently two other perscription products and one OTC that are authorized to contain Metafolin (i.e.; L-methylfolate). Here are the three corresponding websites. What I want you to notice is that every one of them has methyl-B12 in them. Ummm. Coincidence ya think?
http://www.cerefolinnac.com/index.php
http://www.metanx.com/ (scroll to bottom for ingredients)
http://www.hsfighters.com/ingredients.htm
As a side note, the previous site has a good explanation for why methyl-B12 is needed instead of cyanocobalamin. Here's the page:
http://www.hsfighters.com/b12_case.htm
Jamal, Racer, and Jan; here is a very interesting and in-depth presentation by Rodrigo O. Kuljis, M.D. on the topic of using L-methylfolate to tx elderly pts with cognitive decline and the need to supplement the L-methylfolate with methyl-B12. The neurofunctional diagrams presented are applicable to young and old alike, and show the need for the co-administration of methyl-B12 with L-methylfolate.
Here is the link. The presentation should start as soon as you click the link, so have your speakers turned on. If it does not cue up on its own, click the yellow box entitled "A New Option for Memory Loss" in the left hand menu column. The presentation lasts about 20 minutes.
http://www.cerefolinnac.com/HealthcareProfessionals,NewOptionForMemoryLoss
-- Ron
BP II w/ultra rapid cycling; and OCPD
300 mg/day Trileptal
200 mg/day Lamictal
250 mg/day Keppra
82.5 mg/day Nardil
25 mg/day Topamax
7.5 mg/day Deplin
Posted by Phillipa on January 30, 2008, at 19:25:54
In reply to No Pernicious Anaemia » Jamal Spelling » Racer » Phillipa, posted by Ron Hill on January 30, 2008, at 4:27:22
Ron no B12 shots and not taking the other two either if for alzheimers why? Phillipa
This is the end of the thread.
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