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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 14 of 14. This is the beginning of the thread.
Posted by SLS on January 21, 2008, at 4:56:30
Is anyone still responding well to Deplin as of 01-21-2008?
How long have you been taking it?
What dosage?
What other drugs are you taking?
How long did it take to obtain a response?
Any feedback would be greatly appreciated.Thanks.
- Scott
Posted by Phillipa on January 21, 2008, at 10:57:36
In reply to Anyone responding to Deplin as of 01-21-2008?, posted by SLS on January 21, 2008, at 4:56:30
Scott I am 7.5mg for about a week and a half with 50mg of luvox and cut valium as so tired even before by 2.5mg from 20mg. And the minute take the synthroid I start to feel worse and dream and feel wierd that's when I get up for bathroom at about 5am as the endo said. Could green teas interfer as the minute I get out get more tired. Love Phillipa
Posted by SLS on January 25, 2008, at 5:31:19
In reply to Re: Anyone responding to Deplin as of 01-21-2008? » SLS, posted by Phillipa on January 21, 2008, at 10:57:36
I'm trying to get an idea as to how likely Deplin is to poop-out, and under what circumstances.
Thanks.
http://www.dr-bob.org/babble/20080114/msgs/808082.html
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Is anyone still responding well to Deplin as of 01-21-2008?
How long have you been taking it?
What dosage?
What other drugs are you taking?
How long did it take to obtain a response?
Any feedback would be greatly appreciated.Thanks.
- Scott
Posted by iforgotmypassword on January 25, 2008, at 13:59:42
In reply to NO ONE responding to Deplin as of 01-21-2008?, posted by SLS on January 25, 2008, at 5:31:19
> I'm trying to get an idea as to how likely Deplin is to poop-out, and under what circumstances.
a very important thing to find out. good idea. from what i have read phillipa and ron hill may have had responses that would be explained suitably as pooping out.
please keep updating us. thanks.
(oh and if you can explain if deplin really only has a meaningful benefit after several weeks. thanks)
Posted by clipper40 on January 25, 2008, at 19:23:22
In reply to Re: NO ONE responding to Deplin as of 01-21-2008? » SLS, posted by iforgotmypassword on January 25, 2008, at 13:59:42
I think Ron Hill realized he was taking too much and cut back to just one pill. I believe he got back his initial good response that way but he hasn't posted in a while so I'm not sure if he was able to maintain it.
Posted by Phillipa on January 25, 2008, at 19:51:04
In reply to Re: NO ONE responding to Deplin as of 01-21-2008?, posted by clipper40 on January 25, 2008, at 19:23:22
Yes Ron was on l5mg and did cut back and think he obtained a response not sure maybe he will post. So far no response except for one day. Waiting it out. Phillipa
Posted by Ron Hill on January 26, 2008, at 0:26:15
In reply to Re: NO ONE responding to Deplin as of 01-21-2008?, posted by clipper40 on January 25, 2008, at 19:23:22
C40 et al,
Yes, you have it right, C40. I take 7.5 mg/day of Deplin with my other meds. Deplin provides a small positive effect on my mood, but nothing like it did at start-up. However, if I take a break from Deplin for about a week, then I experience a very pleasant, peaceful mood when I restart Deplin. This restart response is similar to my original start-up response, just not nearly as profound.
The main reason that I continue to take Deplin is to offset the folate loss due to taking antiepileptic medications. And, secondarily, I think it provides me some amount of an antidepressant effect.
May I take a minute to get up on my soapbox? Thank you.
ATTENTION ALL DEPLIN USERS: It is VERY important to take methyl-B12 with your Deplin. In the absence of B12 supplementation, folate (in this case L-methylfolate) depletes the body of B12. The very best form of B12 to take is sublingual methyl-B12 (methylcobalamin).
Also, P-5-P (the coenzymatic form of B6) should be taken with Deplin.
There is good reason why Metanx contains both methylcobalamin and P-5-P to go along with the L-methylfolate.
http://www.metanx.com/ (scroll to bottom of page)
Methyl-B12 is the coenzyme that interacts with L-methylfolate and feeds the Methylation Cycle. So, if we continue to take Deplin over an extended period of time without also taking methyl-B12, then B12 will become in short supply. Without sufficient B12, the L-methylfolate gets stuck in the methyl trap. Further, all kinds of serious problems occur due to B12 deficiency.
A picture is worth a thousand words. The link below is a scientific review of Metafolin (L-methylfolate). Go to page 5 of the pdf document, read the section titled "Cellular Folate Metabolism and Masking of B12 Deficiency", and examine the drawings carefully.
http://www.metafolin.com/pdfs/Scientific_Review_13.12.pdf
As always, tell me if I have something wrong.
-- Ron
300 mg/day Trileptal
200 mg/day Lamictal
250 mg/day Keppra
25 mg/day Topamax
82.5 mg/day Nardil
7.5 mg/day Deplin--------------------
> I think Ron Hill realized he was taking too much and cut back to just one pill. I believe he got back his initial good response that way but he hasn't posted in a while so I'm not sure if he was able to maintain it.
Posted by henryo on January 26, 2008, at 13:48:03
In reply to Anyone responding to Deplin as of 01-21-2008?, posted by SLS on January 21, 2008, at 4:56:30
I responded fantastically in 24 hours. Posted about it. Going strong. Love it.
Posted by Phillipa on January 26, 2008, at 19:01:59
In reply to Re: Anyone responding to Deplin as of 01-21-2008?, posted by henryo on January 26, 2008, at 13:48:03
Henro are you also taking the other supplements as the drug rep said nothing to my pdoc so only deplin is what I'm on. Phillipa ps thanks Ron for posting this since I don't have any response and not on anaticonvulsants may just stop it what's the point in spending money if it doesn't work for me.
Posted by henryo on January 28, 2008, at 1:30:18
In reply to Re: Anyone responding to Deplin as of 01-21-2008? » henryo, posted by Phillipa on January 26, 2008, at 19:01:59
Yes. I take Lamictal. Deplin is billed on their site as an AD augmentation. It helps other ADs be more effective. But hey if it works for you alone, even better. I had to cut back on my Lamictal. I used to get this weird side effect whenever I moved my dose up to 250mgs. I could watch myself sleep. Weird I know. So I've always taken 200 but after Deplin and my wonderful response to it I've cut the Lamictal back because that sleep thing started to happen again. Hey Deplin is not a pharmaceutical and less Lamictal is fine with me. As long as I feel great and I'm taking fewer meds ROCK ON.
Posted by henryo on January 28, 2008, at 1:42:06
In reply to Re: Anyone responding to Deplin as of 01-21-2008? » henryo, posted by Phillipa on January 26, 2008, at 19:01:59
Supplements like vitamins? Nothing was ever said to me about Deplin and supplements.
There is nothing on the website. I tried B12, I broke out terribly (at 45). I've always taken enough fish oil to get 1000mgs DHA. And so I take ester vitamin C. I take a multi from Trader Joe's cause it has all the selenium, chromium, zinc and whatever that people always carry on about. Not that it ever did a thing for me. But I would try anything and everything. I'm sure I eliminate 99.9 percent of it every day.
Posted by SLS on January 31, 2008, at 6:27:29
In reply to Re: NO ONE responding to Deplin as of 01-21-2008? » SLS, posted by iforgotmypassword on January 25, 2008, at 13:59:42
Hi forgotmypassword.
> > I'm trying to get an idea as to how likely Deplin is to poop-out, and under what circumstances.
>
> a very important thing to find out. good idea. from what i have read phillipa and ron hill may have had responses that would be explained suitably as pooping out.
>
> please keep updating us. thanks.
>
> (oh and if you can explain if deplin really only has a meaningful benefit after several weeks. thanks)I have discontinued Deplin for a variety of reasons, most importantly because I questioned its effectiveness for ME during chronic use.
I feel fine!
Poop-out? I think yes.
Sometimes, there is insufficient evidence of efficacy if observed longitudinally. The "medical food" moniker seems to need less clinical evidence through controlled trials in order to be approved by the FDA. This is particularly true of Deplin. It might work for some people long-term. I encourage as many people as possible report their experiences with Deplin.
- Scott
Posted by zatar on February 4, 2008, at 14:39:14
In reply to Anyone responding to Deplin as of 01-21-2008?, posted by SLS on January 21, 2008, at 4:56:30
To see if you would benefit from Deplin or other methylation supplements, would it make sense to do this methylation pathway analysis (nutrigenomic)from Amy Yasko's website?
Any thoughts about this test? Is it that simple to see the faulty step and correct it?
Thanks.
-zatar
Posted by Fivefires on February 5, 2008, at 10:06:56
In reply to Re: NO ONE responding to Deplin as of 01-21-2008? » iforgotmypassword, posted by SLS on January 31, 2008, at 6:27:29
Blood tests indicated B-12 and folate low so I give myself a B-12 shot every 3wks and, because I get samples of Deplin, I've been taking just one-half of the 7.5 Deplin tablet daily.
I had been taking a folic acid or folate, but w/ the good reaction I first got w/ Deplin, I feel there must be something to it.
Maybeeeee .. taking too much of it is the problem.
Just my 2cents.
5f
This is the end of the thread.
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