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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 13 of 13. This is the beginning of the thread.
Posted by sdb on January 16, 2008, at 14:00:21
what do you think about that after having experiences with these two drugs? 1/4 lexapro/celexa ratio and the same efficacy in spite of removing one isomer?
warm regards
sdb
Posted by Phillipa on January 16, 2008, at 19:23:42
In reply to lexapro/celexa, is the difference only the price?, posted by sdb on January 16, 2008, at 14:00:21
I only have an experience and that is 30days of celexa made me so tired. And lexapro made axiety too bad to take even with benzos. So what does that mean? Phillipa
Posted by Justherself54 on January 16, 2008, at 23:42:38
In reply to Re: lexapro/celexa, is the difference only the price? » sdb, posted by Phillipa on January 16, 2008, at 19:23:42
celexa didn't help much..lexparo seemed much stronger and more effective..more like a ramped up celexa..
Posted by bonbon on January 17, 2008, at 4:41:11
In reply to Re: lexapro/celexa, is the difference only the pri, posted by Justherself54 on January 16, 2008, at 23:42:38
for me, lexapro was a milder form of celexa. instead of having such terrible nightmares that i never wanted to go sleep, the lexapro just caused me to sleep with my muscles all clenched up. neither was pleasant, and in the end, neither worked.
bonbon
Posted by sdb on January 17, 2008, at 10:14:19
In reply to lexapro/celexa, is the difference only the price?, posted by sdb on January 16, 2008, at 14:00:21
I've heard more people still on celexa. It could be the price, generics, people not like changing something that works, celexa is different compared to lexapro,... what I've seen also is more tca's again.
Philippa: nausea and anxiety, panic attacks is very often mentioned when starting an ssri
Posted by qbsbrown on January 17, 2008, at 12:16:34
In reply to lexapro/celexa, is the difference only the price?, posted by sdb on January 16, 2008, at 14:00:21
Yes, they had a complete opposite effect for me, a 180. I found the ratio closer of 3-1. One of my docs even said it's 2-1.
Brian
Posted by jms600 on January 19, 2008, at 16:12:15
In reply to Re: lexapro/celexa, is the difference only the pri, posted by qbsbrown on January 17, 2008, at 12:16:34
I think the only real way to find out is to try them yourself and monitor how each drug makes you feel and what side effects are present. Maybe try 3-4 months on Celexa and then 3-4 months on Lexapro??
I know it's not an ideal way forward, but the trouble is everyone one of us is so different. I read some archive articles on Psycho-Babble, yesterday, from a few years back. One post was on Effexor, and some people were saying how it really helped them. Effexor did nothing much for me apart from make me sluggish and sleepy - all I wanted to do was lie down all day and do absolutely nothing.
It just goes to show that what works for one doesn't necessarily work for another and vice-versa.
Good luck!
Posted by Cecilia on January 20, 2008, at 12:31:36
In reply to lexapro/celexa, is the difference only the price?, posted by sdb on January 16, 2008, at 14:00:21
According to my doctor they're the same, Lexapro was just invented because the Celexa patent was expiring. Cecilia
Posted by Larry Hoover on January 20, 2008, at 13:16:28
In reply to lexapro/celexa, is the difference only the price?, posted by sdb on January 16, 2008, at 14:00:21
> what do you think about that after having experiences with these two drugs? 1/4 lexapro/celexa ratio and the same efficacy in spite of removing one isomer?
>
> warm regards
>
> sdbI haven't taken either of these two drugs, but pharmacological studies have shown that the R-enantiomer of citalopram acts as an inhibitor of serotonin reuptake inhibitors (not just its S-enantiomer, i.e. escitalopram, or Lexapro). In other words, Celexa contains a self-inhibitor that has been removed from Lexapro. The magnitude of the R-citalopram inhibitory effect varies, depending on genetic differences in the structure of the serotonin transporter, but the effect is universal. So, Lexapro is a superior antidepressant, which may work in some individuals where Celexa has failed. It's more than just a cynical money-grab patent-extension.
Lar
Posted by Cecilia on January 20, 2008, at 23:13:17
In reply to Re: lexapro/celexa, is the difference only the price? » sdb, posted by Larry Hoover on January 20, 2008, at 13:16:28
> > what do you think about that after having experiences with these two drugs? 1/4 lexapro/celexa ratio and the same efficacy in spite of removing one isomer?
> >
> > warm regards
> >
> > sdb
>
> I haven't taken either of these two drugs, but pharmacological studies have shown that the R-enantiomer of citalopram acts as an inhibitor of serotonin reuptake inhibitors (not just its S-enantiomer, i.e. escitalopram, or Lexapro). In other words, Celexa contains a self-inhibitor that has been removed from Lexapro. The magnitude of the R-citalopram inhibitory effect varies, depending on genetic differences in the structure of the serotonin transporter, but the effect is universal. So, Lexapro is a superior antidepressant, which may work in some individuals where Celexa has failed. It's more than just a cynical money-grab patent-extension.
>
> Lar
Larry, is this regardless of dose? Of course Lexapro is supposed to works at a lower dose than Celexa, but if someone takes a full 60 mg of Celexa does this inhibitory effect still exist? I took Celexa for years, at various doses, not because it worked but because it had no side effects. "Augmented" at various times with Wellbutrin, gabapentin, Buspar, Lamictal, clonazepam, without benefit. Could someone really have no benefit from Celexa but benefit from Lexapro, or is it just that someone who responded moderately to Celexa might have a stronger response to Lexapro? Cecilia
Posted by sdb on January 21, 2008, at 16:37:26
In reply to Re: lexapro/celexa, is the difference only the price? » sdb, posted by Larry Hoover on January 20, 2008, at 13:16:28
thanks everybody...!
second citation of the day:
politicians see or do have always a problem and when they don't see or have one they instantly have invented one.
sdb, owner of a brain
Posted by Larry Hoover on January 22, 2008, at 10:08:11
In reply to Re: lexapro/celexa, is the difference only the pri » Larry Hoover, posted by Cecilia on January 20, 2008, at 23:13:17
> Larry, is this regardless of dose? Of course Lexapro is supposed to works at a lower dose than Celexa, but if someone takes a full 60 mg of Celexa does this inhibitory effect still exist?
The inhibitory effect increases with dose, as well. R-citalopram changes the conformation of the SERT (serotonin transporter) active site, but by binding elsewhere (i.e. allosteric inhibition). I'd expect that increasing the dose of Celexa would take out more and more transporters.
What I haven't seen is an analysis of the effect of R-citalopram on serotonin binding to SERT. It's quite clear, however, that R-citalopram inhibits S-citalopram binding to SERT. I don't think increasing the dose could possibly overcome this conformational change in the reuptake transporter.
> I took Celexa for years, at various doses, not because it worked but because it had no side effects. "Augmented" at various times with Wellbutrin, gabapentin, Buspar, Lamictal, clonazepam, without benefit. Could someone really have no benefit from Celexa but benefit from Lexapro, or is it just that someone who responded moderately to Celexa might have a stronger response to Lexapro? Cecilia
I think it is quite possible that someone who had no benefit from Celexa could have a significant response to Lexapro. The thing is, there is no way to distinguish such individuals from those who would not respond to this drug no matter how it was administered. Well, there is one way.....do the experiment.
Lar
Posted by Phillipa on January 22, 2008, at 19:57:55
In reply to Re: lexapro/celexa, is the difference only the pri » Cecilia, posted by Larry Hoover on January 22, 2008, at 10:08:11
As Nike says Just Do It!!!!! My favorite mantra. Phillipa
This is the end of the thread.
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