Posted by Larry Hoover on January 22, 2008, at 10:08:11
In reply to Re: lexapro/celexa, is the difference only the pri » Larry Hoover, posted by Cecilia on January 20, 2008, at 23:13:17
> Larry, is this regardless of dose? Of course Lexapro is supposed to works at a lower dose than Celexa, but if someone takes a full 60 mg of Celexa does this inhibitory effect still exist?
The inhibitory effect increases with dose, as well. R-citalopram changes the conformation of the SERT (serotonin transporter) active site, but by binding elsewhere (i.e. allosteric inhibition). I'd expect that increasing the dose of Celexa would take out more and more transporters.
What I haven't seen is an analysis of the effect of R-citalopram on serotonin binding to SERT. It's quite clear, however, that R-citalopram inhibits S-citalopram binding to SERT. I don't think increasing the dose could possibly overcome this conformational change in the reuptake transporter.
> I took Celexa for years, at various doses, not because it worked but because it had no side effects. "Augmented" at various times with Wellbutrin, gabapentin, Buspar, Lamictal, clonazepam, without benefit. Could someone really have no benefit from Celexa but benefit from Lexapro, or is it just that someone who responded moderately to Celexa might have a stronger response to Lexapro? Cecilia
I think it is quite possible that someone who had no benefit from Celexa could have a significant response to Lexapro. The thing is, there is no way to distinguish such individuals from those who would not respond to this drug no matter how it was administered. Well, there is one way.....do the experiment.
Lar
poster:Larry Hoover
thread:807013
URL: http://www.dr-bob.org/babble/20080114/msgs/808302.html