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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by mav27 on September 17, 2007, at 5:54:23
Hi, just have a couple questions regarding nardil which i have just started for the first time. First how much should the dose be spread out during the day? I'm taking it in the morning and then afternoon, is this ok or should i spread it out morning noon and night? I'm not having any probs with side effects so far at 60mg.
Also i was wondering if there is any tests that can be done to either check how much nardil is making it into your blood, and how much is usually the theraputic amount? Or a test for how much MAO inhibition is actually occuring? I was just thinking with this concern for the new nardil it may be helpfull to check to see that it's doing what it should or that i'm taking the needed dose.
Posted by Brody on September 18, 2007, at 20:03:33
In reply to nardil questions, posted by mav27 on September 17, 2007, at 5:54:23
> Hi, just have a couple questions regarding nardil >
>Hi Mav27,
You might want to scroll up a ways to a thread started on 9/12 by FOOTBALL. This was just discussed, and there are informative posts there that may answer some of your Nardil questions.
Good Luck,
Janet
Posted by tecknohed on September 19, 2007, at 5:46:48
In reply to nardil questions, posted by mav27 on September 17, 2007, at 5:54:23
Hi.
Cant find the thread Brody mentions, but as a GENERAL rule the correct dosage as about 1mg per kg of body weight. So, if you weigh, say 75kg, then you'd need 75mg/day of Nardil. Although the initial effective dose might be much lower & you'll need to increase as & when needed.As for spreading out the dose, it may depend on whether you take it for depression alone or for any anxiety related issues , with or without depression.
For depression alone, its MAO blocking effect is probably enough by itself. And although Nardil has a short half life, it continues to block MAO for many days after stopping (after continued & prolonged dosing) and so continuing to lift depression, so dosing once-daily would be OK. This may also be why some sources recommend such a low maintanance dose (as low as 15mg every other day) as this is still enough to block MAO.HOWEVER, Nardil also has a potent GABA effect which, from my experience, lasts as long as Nardil's peak blood levels, in which case spreading your full dose throughout the day would be best in cases of anxiety. You'd also need to stay on the dose which gets you better throughout your time on the drug in cases of anxiety.
Do bare in mind that it can take a good while for this drug to work. Say, for example, on week 6 you increased from 60mg to 90mg/day and it then kicked in strait away. OK so your better but it doesn't leave you much room to increase the dose should you need to, and it may have kicked in at 45mg/day at week 8. So my advice is increase as slowly as you possibly can. For me, it kicked in as soon as I hit 60mg/day after 3 weeks, which tells me it probably would have kicked in at 45mg/day after 4 to 6 weeks.
And try not to toy with the dose as this can be detrimental to the drugs positive effects (as I found out). Many people have found this out the hard way.
But dont take my advice over your doctor's. Mine is based only from experience & what I've read on this board.
Hope 'some' of that makes sense!
Good luck with it - its LUSH when it does work!
Posted by mav27 on September 19, 2007, at 23:41:38
In reply to Re: nardil questions » mav27, posted by tecknohed on September 19, 2007, at 5:46:48
Thanks for the replies.
I've only been on it a week but i'm sure it's already had some effect. Although not in relation to the depression or anxiety as such but when it comes to talking to people (as i'm taking this for social phobia mostly) i have found i can talk much more spontaneously. Like rather than thinking about what to say and worrying about saying something stupid i'm finding i'm just talking without thinking about it and seem to be much more talkative as a result. So far it's looking very promising.
Posted by cumulative on September 20, 2007, at 16:06:59
In reply to Re: nardil questions » mav27, posted by tecknohed on September 19, 2007, at 5:46:48
>And although Nardil has a short half life, it continues to block MAO for many days after stopping (after continued & prolonged dosing) and so continuing to lift depression, so dosing once-daily would be OK
I think, though, that the metabolites of Nardil (which include phenethylamine) need to be considered in the antidepressant effect.
Thanks for the post tecknohed, very informative.
To the OP: while I'm not aware of any good test that would reveal plasma MAO inhibition in humans, the dose at which the full antidepressant effect kicks in, might, with Nardil, be somewhat obvious. One advantage of this drug.
Posted by blueboy on September 25, 2007, at 10:35:50
In reply to Re: nardil questions » mav27, posted by tecknohed on September 19, 2007, at 5:46:48
I'm not going to disagree with your general idea, but I will say, at 6'1" and 100-110 kg, I need 60mg Nardil per day for full effect (and horrendous side effects). There is apparently a lot of very individual difference.
I have found a 10-day correlation between dosing and effect.
> Hi.
> Cant find the thread Brody mentions, but as a GENERAL rule the correct dosage as about 1mg per kg of body weight. So, if you weigh, say 75kg, then you'd need 75mg/day of Nardil. Although the initial effective dose might be much lower & you'll need to increase as & when needed.
Posted by Brody on September 25, 2007, at 11:21:40
In reply to Re: nardil questions » mav27, posted by tecknohed on September 19, 2007, at 5:46:48
> Hi.
> Cant find the thread Brody mentions.....>
>
Sorry... I should have provided the link the first time... Janethttp://www.dr-bob.org/babble/20070911/msgs/782465.html
This is the end of the thread.
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