Posted by tecknohed on September 19, 2007, at 5:46:48
In reply to nardil questions, posted by mav27 on September 17, 2007, at 5:54:23
Hi.
Cant find the thread Brody mentions, but as a GENERAL rule the correct dosage as about 1mg per kg of body weight. So, if you weigh, say 75kg, then you'd need 75mg/day of Nardil. Although the initial effective dose might be much lower & you'll need to increase as & when needed.As for spreading out the dose, it may depend on whether you take it for depression alone or for any anxiety related issues , with or without depression.
For depression alone, its MAO blocking effect is probably enough by itself. And although Nardil has a short half life, it continues to block MAO for many days after stopping (after continued & prolonged dosing) and so continuing to lift depression, so dosing once-daily would be OK. This may also be why some sources recommend such a low maintanance dose (as low as 15mg every other day) as this is still enough to block MAO.HOWEVER, Nardil also has a potent GABA effect which, from my experience, lasts as long as Nardil's peak blood levels, in which case spreading your full dose throughout the day would be best in cases of anxiety. You'd also need to stay on the dose which gets you better throughout your time on the drug in cases of anxiety.
Do bare in mind that it can take a good while for this drug to work. Say, for example, on week 6 you increased from 60mg to 90mg/day and it then kicked in strait away. OK so your better but it doesn't leave you much room to increase the dose should you need to, and it may have kicked in at 45mg/day at week 8. So my advice is increase as slowly as you possibly can. For me, it kicked in as soon as I hit 60mg/day after 3 weeks, which tells me it probably would have kicked in at 45mg/day after 4 to 6 weeks.
And try not to toy with the dose as this can be detrimental to the drugs positive effects (as I found out). Many people have found this out the hard way.
But dont take my advice over your doctor's. Mine is based only from experience & what I've read on this board.
Hope 'some' of that makes sense!
Good luck with it - its LUSH when it does work!
poster:tecknohed
thread:783426
URL: http://www.dr-bob.org/babble/20070919/msgs/783877.html