Shown: posts 1 to 17 of 17. This is the beginning of the thread.
Posted by brooke484 on July 5, 2007, at 8:59:02
I took klonopin in the past with great results but went off it because the dose I was taking was no longer working and I didn't want to increase it. So anyway, I've been taking Ativan for the last few years and it works only so-so. My doctor just prescribed .5 mgs of klonopin and I took the first pill this morning and it was horrible. I feel like I could jump out of my skin and thought I was going to have a panic attack. I wanted to take some ativan but wasn't sure if I could do that. My doctor is out of town until Mon and the pharmacist I spoke with said there is an interaction between the two drugs (they can increase side effects or something like that). But since I was taking ativan with no problems, why would klonopin make me feel so sick? Help!
brooke
Posted by Justherself54 on July 5, 2007, at 14:14:44
In reply to Klonopin + Nardil = Major Anxiety???, posted by brooke484 on July 5, 2007, at 8:59:02
> I took klonopin in the past with great results but went off it because the dose I was taking was no longer working and I didn't want to increase it. So anyway, I've been taking Ativan for the last few years and it works only so-so. My doctor just prescribed .5 mgs of klonopin and I took the first pill this morning and it was horrible. I feel like I could jump out of my skin and thought I was going to have a panic attack. I wanted to take some ativan but wasn't sure if I could do that. My doctor is out of town until Mon and the pharmacist I spoke with said there is an interaction between the two drugs (they can increase side effects or something like that). But since I was taking ativan with no problems, why would klonopin make me feel so sick? Help!
>
> brookeWhat dose of Ativan were you taking? It sounds more like a withdrawal reaction to the Ativan rather than the Klonopin?
Posted by brooke484 on July 5, 2007, at 21:27:37
In reply to Re: Klonopin + Nardil = Major Anxiety???, posted by Justherself54 on July 5, 2007, at 14:14:44
I only take ativan once or twice a week. And there have been weeks that I haven't taken any at all. I swear, about 10 minutes after I took klonopin I felt ill. I've never experienced anything like this before. I'm disappointed because when I was off Nardil the klonopin worked great. I was hoping I could take the two together.
brooke
Posted by Justherself54 on July 5, 2007, at 21:40:13
In reply to Re: Klonopin + Nardil = Major Anxiety???, posted by brooke484 on July 5, 2007, at 21:27:37
That's got to be so disappointing..I would be scared to take another one too if that happened to me..if your anxiety gets to much are you able to call a doctor and discuss it with him/her? I have experienced severe anxiety/panic attacks before and I know how awful you feel while you're trying to hang on by your toenails..
Hope you can get some relief..
Posted by marshall26 on July 6, 2007, at 4:06:07
In reply to Klonopin + Nardil = Major Anxiety???, posted by brooke484 on July 5, 2007, at 8:59:02
I had a similar interaction between Klonopin and Zoloft. Klonopin has a greater frequency of paradoxical side effects than other benzos. Also MAOIs are known to have a lot of interactions with other drugs. Is there anything you could substitute for Nardil that isn’t an MAOI.
You could also ask for Valium instead of Klonopin. It’s too bad doctors don’t like to prescribe Valium. They prefer the more potent shorter acting benzos that have more side effects and harsher withdrawals.
Posted by brooke484 on July 6, 2007, at 21:08:44
In reply to Re: Klonopin + Nardil = Major Anxiety???, posted by marshall26 on July 6, 2007, at 4:06:07
I can't give up on nardil just yet. It could be my last resort. I guess I'll just have to stick with ativan and if I ever stop nardil it'll be klonpin again.
brooke
Posted by brooke484 on July 6, 2007, at 21:12:42
In reply to Re: Klonopin + Nardil = Major Anxiety???, posted by Justherself54 on July 5, 2007, at 21:40:13
My doctor is on vacation until Mon and I will give him a call then. The ativan has been working ok, but lately I've been having worse anxiety so I wanted to try klonopin again. I don't really understand what's happening because the last 2 weeks my anxiety has increased, a lot. I just had my thyroid tested so we'll see if that's the reason. I've been on Nardil 5 weeks but it never increased my anxiety so I have no idea what's going on.
brooke
Posted by Jedi on July 7, 2007, at 4:24:03
In reply to Re: Klonopin + Nardil = Major Anxiety- justherself, posted by brooke484 on July 6, 2007, at 21:12:42
Hi brooke,
Everyone is different, but I took clonazepam with Nardil for years with no ill effects. In fact, I believe for social anxiety, the two meds are really the Gold standard. They both affect GABA and for me the synergism of the two was very good for anxiety.I can't think of a reason you reacted the way you did, especially since you have taken clonazepam in the past. Your plan is sound, tough it out until Monday and ask your Doc. Maybe you need a dosage adjustment on the Nardil. The generally accepted effective dose is 1mg/kg of body weight (divide your weight in pounds by 2.2). Good luck with the Nardil. It saved my life more than once.
Take care,
Jedi> My doctor is on vacation until Mon and I will give him a call then. The ativan has been working ok, but lately I've been having worse anxiety so I wanted to try klonopin again. I don't really understand what's happening because the last 2 weeks my anxiety has increased, a lot. I just had my thyroid tested so we'll see if that's the reason. I've been on Nardil 5 weeks but it never increased my anxiety so I have no idea what's going on.
>
> brooke
Posted by brooke484 on July 7, 2007, at 21:37:58
In reply to Re: Klonopin + Nardil = Major Anxiety » brooke484, posted by Jedi on July 7, 2007, at 4:24:03
Well, I hope it saves my life because I've never felt worse. I've been on 60 mgs for one week (I started the drug 5 weeks ago) and I'm about 135 lbs, so that should be the correct dose. I hope it works.
I just assumed that because I am taking Ativan I could also take Klonopin. It was just weird. I felt tingly all over and like I could jump out of my skin. It scared me. And that was only .5 mgs. When I took it alone I noticed a huge difference, but when I take it with any other medication it doesn't work as well. Ativan isn't as strong as it used to be. That's why I wanted to give klonpin another try. Oh well.
Enough rambling. Thanks for your post.
Brooke :)
Posted by Kneeko on September 3, 2007, at 19:49:02
In reply to Re: Klonopin + Nardil = Major Anxiety » brooke484, posted by Jedi on July 7, 2007, at 4:24:03
A question, if you weigh 220-230 lbs(102-103kg), would a dose of 75 mgs often be insufficient? Nardil seems to be helping a little bit, but feels like something is missing, Side effects don't bother me too much.
Also another few questions, is Zyprexa really a decent augmentation agent for Nardil? it seems like it would exacerbate depression given the fact that it blocks dopamine.
Posted by Jedi on September 3, 2007, at 22:39:55
In reply to Re: Klonopin + Nardil = Major Anxiety, posted by Kneeko on September 3, 2007, at 19:49:02
Kneeko,
In your situation, if the depression or anxiety is not being handled completely at 75mg, I would take it up to 90mg.I have never taken Zyprexa, but I would think that unless you are bipolar or have psychotic depression, it might not be the best augmentor. I do take a small dose of quetiapine(Seroquel)-25mg to counteract the insomnia induced by Nardil. At this low dosage quetiapine has an antagonistic effect on the histamine H1 receptor, which accounts for its beneficial effect on insomnia. At higher dosages this med can affect the dopamine and serotonin receptors.
Be Well,
Jedi
> A question, if you weigh 220-230 lbs(102-103kg), would a dose of 75 mgs often be insufficient? Nardil seems to be helping a little bit, but feels like something is missing, Side effects don't bother me too much.
>
> Also another few questions, is Zyprexa really a decent augmentation agent for Nardil? it seems like it would exacerbate depression given the fact that it blocks dopamine.
>
>
Posted by Kneeko on September 4, 2007, at 15:54:23
In reply to Re: Klonopin + Nardil = Major Anxiety » Kneeko, posted by Jedi on September 3, 2007, at 22:39:55
> Kneeko,
> In your situation, if the depression or anxiety is not being handled completely at 75mg, I would take it up to 90mg.
>
> I have never taken Zyprexa, but I would think that unless you are bipolar or have psychotic depression, it might not be the best augmentor. I do take a small dose of quetiapine(Seroquel)-25mg to counteract the insomnia induced by Nardil. At this low dosage quetiapine has an antagonistic effect on the histamine H1 receptor, which accounts for its beneficial effect on insomnia. At higher dosages this med can affect the dopamine and serotonin receptors.
> Be Well,
> Jedi
>
>
> > A question, if you weigh 220-230 lbs(102-103kg), would a dose of 75 mgs often be insufficient? Nardil seems to be helping a little bit, but feels like something is missing, Side effects don't bother me too much.
> >
> > Also another few questions, is Zyprexa really a decent augmentation agent for Nardil? it seems like it would exacerbate depression given the fact that it blocks dopamine.
> >
> >
>
>
Thankyou, Jedi. I did have a manic episode about 18 months ago on Nardil, at which time I was placed on Zyprexa for the last 18 months, it doesn't seem to really do that much.Was interested in what agents you think might augment Nardil? The SSRI's did nothing, and Noradrenaline and Stimulant based meds cause agitation. Currently Im trying 2.5mg Zyprexa, and 300mgs lithium for augmentation. Would Nortryptiline or Mirapex(perhaps both) be good agents to try Nardil?
Thankyou
Posted by brooke484 on September 4, 2007, at 20:54:29
In reply to Re: Klonopin + Nardil = Major Anxiety, posted by Kneeko on September 4, 2007, at 15:54:23
What about Lamictal or Neurotin? I read about one woman (on another site) who had success with Parnate and Neurotin. She said she's never felt better.
brooke
Posted by Jedi on September 5, 2007, at 2:02:52
In reply to Re: Klonopin + Nardil = Major Anxiety, posted by Kneeko on September 4, 2007, at 15:54:23
Kneeko,
I had a similar hypomanic experience when I started Nardil about ten years ago. I think it is quite common and for me it felt really good after being depressed for so long and trying so many different drug combinations. I didn't take anything for it and the hypomanic feeling soon went away.I'm sure you didn't mean to suggest augmentation of Nardil with the SSRI's. This, of course, could lead to the long dirt nap from serotonin syndrome. Maybe a mild stimulant such as modofinal(Provigil) might help. I have used nortriptyline at 100mg with Nardil at 90mg in the past. It really didn't seem to do much for me. Maybe a higher dosage of notriptyline would help for me since I seem to be a rapid tricyclic metabolizer. The 100mg of notrip did not get me close to the therapeutic window for the mediation.
How does the lithium seem to be working for you? It is on my short list of augmentors to try with Nardil.
I've never used Mirapex but have studied it as an augmentor of Nardil. If your dopamine is in short supply, this med might just help.
Take care,
Jedi> Thankyou, Jedi. I did have a manic episode about 18 months ago on Nardil, at which time I was placed on Zyprexa for the last 18 months, it doesn't seem to really do that much.
>
> Was interested in what agents you think might augment Nardil? The SSRI's did nothing, and Noradrenaline and Stimulant based meds cause agitation. Currently Im trying 2.5mg Zyprexa, and 300mgs lithium for augmentation. Would Nortryptiline or Mirapex(perhaps both) be good agents to try Nardil?
>
> Thankyou
Posted by aabag on September 5, 2007, at 13:13:35
In reply to Re: Klonopin + Nardil = Major Anxiety » Kneeko, posted by Jedi on September 5, 2007, at 2:02:52
Hi Jedi, not sure whether lithium is working or not, have spent alot of time withdrawing from medications, so its hard to tell whether Nardil is doing anything. Also you are right about SSRI's with Nardil, it meant that independently they did nothing.
The 1st and 2nd times on Nardil were great, in that they completly got rid of all self-consciousness, then it pooped out. Had bad reactions to Modafinal, Parnate, Adderall, and Desipramine. This seems to suggest that mechanism of action is not Seretonin or Noradrenaline, but Dopamine. The strategy is to exhaust all possible options with Nardil, just don't know which to employ!
Thanks for the feedback, Jedi
Posted by kneeko on September 5, 2007, at 14:11:20
In reply to Re: Klonopin + Nardil = Major Anxiety, posted by aabag on September 5, 2007, at 13:13:35
That is someone I knows username((sorry aabag), but also had another question, is it possible to add Adrafanil to Nardil without dying? It seems to be effective, and possible that having to two effects reuptake and inhibition would help.
Posted by blueboy on September 7, 2007, at 13:59:57
In reply to Re: Klonopin + Nardil = Major Anxiety » Kneeko, posted by Jedi on September 5, 2007, at 2:02:52
I actually took Mirapex while on Nardil once and I got sick as hell.
There is no published drug interaction, but taking any Parkinson's medication while on Nardil is extremely risky, IMO.
As for the serotonin/hypomania problem, I've been through a lot of it. It's tolerable, from a subjective point of view, although the insomnia can be a bitch. You might try looking at strict dietary regulation, i.e. regulating the amount of L-tryptophan, if it's a big problem.
The worst I ever experienced was taking oral steroids, prescribed by an ENT doc so I could have my sinuses photographed, while on Nardil. One step short of methamphetemine -- some nights I couldn't sleep 2 hours even with medication. I almost lost control in the MRI machine due to total blind screaming panic.
> Kneeko,
> I had a similar hypomanic experience when I started Nardil about ten years ago. I think it is quite common and for me it felt really good after being depressed for so long and trying so many different drug combinations. I didn't take anything for it and the hypomanic feeling soon went away.
>
> I'm sure you didn't mean to suggest augmentation of Nardil with the SSRI's. This, of course, could lead to the long dirt nap from serotonin syndrome. Maybe a mild stimulant such as modofinal(Provigil) might help. I have used nortriptyline at 100mg with Nardil at 90mg in the past. It really didn't seem to do much for me. Maybe a higher dosage of notriptyline would help for me since I seem to be a rapid tricyclic metabolizer. The 100mg of notrip did not get me close to the therapeutic window for the mediation.
>
> How does the lithium seem to be working for you? It is on my short list of augmentors to try with Nardil.
>
> I've never used Mirapex but have studied it as an augmentor of Nardil. If your dopamine is in short supply, this med might just help.
>
> Take care,
> Jedi
>
>
>
> > Thankyou, Jedi. I did have a manic episode about 18 months ago on Nardil, at which time I was placed on Zyprexa for the last 18 months, it doesn't seem to really do that much.
> >
> > Was interested in what agents you think might augment Nardil? The SSRI's did nothing, and Noradrenaline and Stimulant based meds cause agitation. Currently Im trying 2.5mg Zyprexa, and 300mgs lithium for augmentation. Would Nortryptiline or Mirapex(perhaps both) be good agents to try Nardil?
> >
> > Thankyou
>
>
This is the end of the thread.
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