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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by linkadge on February 16, 2007, at 20:45:33
Anyone taken both and can compare? My doctor may try a low dose of either one, but I'd be inclined to the latter as it is not genotoxic.
Linkadge
Posted by Quintal on February 17, 2007, at 12:29:02
In reply to Difference between doxepin and amitryptaline?, posted by linkadge on February 16, 2007, at 20:45:33
I've had the impression doxepin had fewer side effcts and was more tolerable as a sleep aid than amitrityline. I've taken neither so can't really comment. I've never heard of genotoxicity with either drug.
Q
Posted by linkadge on February 17, 2007, at 16:59:00
In reply to Re: Difference between doxepin and amitryptaline? » linkadge, posted by Quintal on February 17, 2007, at 12:29:02
Some of the TCA's are apparently genotoxic and other's aren't.
Linkadge
Posted by Quintal on February 17, 2007, at 17:17:36
In reply to Re: Difference between doxepin and amitryptaline?, posted by linkadge on February 17, 2007, at 16:59:00
I don't doubt it, but I've never heard such myself and it doesn't seem to be a major problem unless it's been covered up of course. Where did you hear about it?
Q
Posted by linkadge on February 17, 2007, at 19:17:57
In reply to Re: Difference between doxepin and amitryptaline? » linkadge, posted by Quintal on February 17, 2007, at 17:17:36
I read about it a little while ago. Althought, the significance of it is debated.
Some studies claim to site an increased risk of cancer years after exposure to the genotoxic TCA's as opposed to the non genotoxic ones.
Linkadge
Posted by Larry Hoover on February 18, 2007, at 18:49:42
In reply to Difference between doxepin and amitryptaline?, posted by linkadge on February 16, 2007, at 20:45:33
> Anyone taken both and can compare? My doctor may try a low dose of either one, but I'd be inclined to the latter as it is not genotoxic.
>
> LinkadgeYou didn't say why you were contemplating this addition, but I'd assume for sleep promotion? If that's the case, I hope you consider trimipramine (Surmontil), 25 mg. It has less hangover than the other two (in my experience), and has nearly the same histaminic bang as does doxepin. Amitryptiline is somewhat weaker than the other two, in that regard.
Lar
Posted by linkadge on February 18, 2007, at 19:47:48
In reply to Re: Difference between doxepin and amitryptaline? » linkadge, posted by Larry Hoover on February 18, 2007, at 18:49:42
Yes, it would be for sleep.
Interesting, I have never actually met somebody who has tried surmontil.
I know you wouldn't have taken a large dose, but in your experience does this drug have any antidepressant effect? (It has no effect on monoamine uptake.)
Linkadge
Posted by linkadge on February 18, 2007, at 19:55:06
In reply to Re: Difference between doxepin and amitryptaline?, posted by linkadge on February 18, 2007, at 19:47:48
Trimipramine supposedly has moderate d2 antagonist affinity.
It is almost an AP
http://en.wikipedia.org/wiki/Trimipramine
Linkadge
Posted by Larry Hoover on February 18, 2007, at 21:27:48
In reply to Re: Difference between doxepin and amitryptaline?, posted by linkadge on February 18, 2007, at 19:47:48
> Yes, it would be for sleep.
>
> Interesting, I have never actually met somebody who has tried surmontil.
>
> I know you wouldn't have taken a large dose, but in your experience does this drug have any antidepressant effect? (It has no effect on monoamine uptake.)
>
> LinkadgeI think I've always thought of it as having a mild antidepressant effect. Just one of many factors. I didn't know about the D2 activity. Thanks for the link, link.
Lar
Posted by exquilter on February 18, 2007, at 23:39:08
In reply to Re: Difference between doxepin and amitryptaline?, posted by linkadge on February 18, 2007, at 19:47:48
I took Surmontil for several years back in the late 80's. With Cytomel, it gave me several good years of anti-depressant activity. Quite sedating, with some weight gain (I was at the high end of the dosage range).
Exquilter
Posted by psychobot5000 on February 20, 2007, at 15:09:47
In reply to Difference between doxepin and amitryptaline?, posted by linkadge on February 16, 2007, at 20:45:33
> Anyone taken both and can compare? My doctor may try a low dose of either one, but I'd be inclined to the latter as it is not genotoxic.
>
> Linkadge
I have taken both, but not for long enough to give a good comparison. What I will say is that amitryptaline is far more anticholinergic (more than atropine at theraputic doses), and so causes more tachycardia--my resting heartrate hovered around 100bpm, which is 20 or 30 higher than normal.Doxepin is more sedating in my experience, with a stronger H1 blocking effect and at least comparable 5-HT2a antagonism. Some researchers seemed to think 5-20mg was an appropriate hypnotic dose. It did helped me sleep, but there was some hangover. Amitryptaline did, too, though--longer half-life.
I know someone who takes doxepin and clearly gets an antidepressant effect from it.
This is the end of the thread.
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