Posted by psychobot5000 on February 20, 2007, at 15:09:47
In reply to Difference between doxepin and amitryptaline?, posted by linkadge on February 16, 2007, at 20:45:33
> Anyone taken both and can compare? My doctor may try a low dose of either one, but I'd be inclined to the latter as it is not genotoxic.
>
> Linkadge
I have taken both, but not for long enough to give a good comparison. What I will say is that amitryptaline is far more anticholinergic (more than atropine at theraputic doses), and so causes more tachycardia--my resting heartrate hovered around 100bpm, which is 20 or 30 higher than normal.Doxepin is more sedating in my experience, with a stronger H1 blocking effect and at least comparable 5-HT2a antagonism. Some researchers seemed to think 5-20mg was an appropriate hypnotic dose. It did helped me sleep, but there was some hangover. Amitryptaline did, too, though--longer half-life.
I know someone who takes doxepin and clearly gets an antidepressant effect from it.
poster:psychobot5000
thread:733407
URL: http://www.dr-bob.org/babble/20070219/msgs/734518.html