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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by Maria3667 on December 28, 2006, at 4:54:56
Hello all,
After taking Tianeptine for almost 3 months, I think I can give a fair account of the pro's and con's of Tianeptine (Stablon).
I started off with the standard dose of 3 tablets of 12.5 mgs Tianeptine daily. In the first 3 weeks, only good effects, like mood brightening and better sleep (with more vivid dreams). Bad effect: slight constipation and weight gain. Then, at about week 5 or 6, I could feel an intense increase in overal sensitivity. I felt more chirpy but on the other hand, cried at the drop of a hat.
The weight gain, constipation and sensitivity became progressively worse as time wore on. The sensitivity increased to a level where I almost became paranoid at very tiny upsets - and even had a very dramatic episode at my work. By this time I constantly needed tranquillizers to dampen the sensitivity. In the end the extreme hypersensitivity (jitters, anxiety) is what makes this drug impossible for me to take (at full dose).
So now I've gone down to 1 tablet per day and still have to take a high dose of laxatives (4 tablets per day) to get any motion in my bowles. I'm still on the sedatives too.
Conclusion: I'm dissapointed at the overal effect. Tianeptine is NOT an anxiolitic! The constipation, weight gain and hypersensitivity are not mentioned in the prescription leaflet.
The only explanation I could find for the hypersensitivity is that Tianeptine seems to have an agonistic effect on the dopamine system by one of it's metabolites. This theory sounds plausible to me - in fact, the effect reminded me very much of Wellbutrin, which I tried last year.
The most positive effect of this drug: hardly any sexual side effects (okay, it takes a little longer, but the orgasmic quality is good).
I hope my experience is individualistic and should not be read as a general conclusion for other people who want to try it. But if this happens to you, you know you are not alone...
Maria
Posted by blueberry1 on December 28, 2006, at 16:48:35
In reply to TIANEPTINE Side effects, posted by Maria3667 on December 28, 2006, at 4:54:56
Thanks for sharing. I found you post very interesting.
Posted by NYCguy on December 28, 2006, at 19:58:44
In reply to TIANEPTINE Side effects, posted by Maria3667 on December 28, 2006, at 4:54:56
Stablon was one of the stangest drugs I've ever tried. The effect of it seemed to change from day to day. Sometimes it would help with depression, sometimes I could tell it was making it a lot worse. After a few months I had to conclude that the lack of S/Es was not worth the lack of efficacy. I mean, there could be some people who got a great benefit from it... but most people seem to report that it was either "strange" or simply ineffective.
Posted by medievil on December 29, 2006, at 6:27:40
In reply to Re: TIANEPTINE Side effects, posted by NYCguy on December 28, 2006, at 19:58:44
this one of the "non effective" drugs that seems to be very effective in really high doses
a bit expensive tough
Posted by Maria3667 on January 3, 2007, at 8:56:58
In reply to Re: TIANEPTINE Side effects, posted by medievil on December 29, 2006, at 6:27:40
> this one of the "non effective" drugs that seems to be very effective in really high doses
> a bit expensive toughDepends on where you buy it...
Latest update: I've quit Tianeptine all together now. A few days later my extreme hypersensitivity level dropped back to 'normal hypersensitivity'.
I think it's fair to give a warning to people who are interested in trying this AD out. If your dopamine level is within range, Tianeptine could make you awfully anxious - even to a degree of becomming paranoid. I've certainly had my share of frightful episodes these last months...
Buyer beware!
My best,
Maria
Posted by liliths on January 15, 2007, at 13:54:44
In reply to TIANEPTINE Side effects, posted by Maria3667 on December 28, 2006, at 4:54:56
hi Maria
I was 'this' close to placing an order for tianeptine but decided I ought to do a bit more research as it comes off sounding almost too good to be true
weight gain????? You experienced weight gain on it? Did you also have weight gain when you took wellbutrin as it's known for NOT being associated it
weight gain is at the top of my no-no list of side effects of any med. Simply can't be less depressed if my bodyfat goes up.
figured I'd better ask before spending all that $
btw, I supplement with approx. 1000mg magnesium daily to offset med induced constipation... seems to help
thanks
namaste,
lilith> Hello all,
>
> After taking Tianeptine for almost 3 months, I think I can give a fair account of the pro's and con's of Tianeptine (Stablon).
>
> I started off with the standard dose of 3 tablets of 12.5 mgs Tianeptine daily. In the first 3 weeks, only good effects, like mood brightening and better sleep (with more vivid dreams). Bad effect: slight constipation and weight gain. Then, at about week 5 or 6, I could feel an intense increase in overal sensitivity. I felt more chirpy but on the other hand, cried at the drop of a hat.
>
> The weight gain, constipation and sensitivity became progressively worse as time wore on. The sensitivity increased to a level where I almost became paranoid at very tiny upsets - and even had a very dramatic episode at my work. By this time I constantly needed tranquillizers to dampen the sensitivity. In the end the extreme hypersensitivity (jitters, anxiety) is what makes this drug impossible for me to take (at full dose).
>
> So now I've gone down to 1 tablet per day and still have to take a high dose of laxatives (4 tablets per day) to get any motion in my bowles. I'm still on the sedatives too.
>
> Conclusion: I'm dissapointed at the overal effect. Tianeptine is NOT an anxiolitic! The constipation, weight gain and hypersensitivity are not mentioned in the prescription leaflet.
>
> The only explanation I could find for the hypersensitivity is that Tianeptine seems to have an agonistic effect on the dopamine system by one of it's metabolites. This theory sounds plausible to me - in fact, the effect reminded me very much of Wellbutrin, which I tried last year.
>
> The most positive effect of this drug: hardly any sexual side effects (okay, it takes a little longer, but the orgasmic quality is good).
>
> I hope my experience is individualistic and should not be read as a general conclusion for other people who want to try it. But if this happens to you, you know you are not alone...
>
> Maria
Posted by Declan on January 18, 2007, at 13:38:42
In reply to Re: TIANEPTINE Side effects » Maria3667, posted by liliths on January 15, 2007, at 13:54:44
I can understand people finding tianeptine anxiety producing. There was some nervous irritation from it.
And maybe even a little constipation and weight gain (?), but if so not much.The nice thing with tianeptine was that I knew it would suit me from about Day 2 (at the latest).
It's not perfect, but is easily the best AD I've tried.
But my experience is only with Parnate, deprenyl, moclobemide, and Remeron (only 2 doses of that one).
Posted by liliths on January 18, 2007, at 15:38:54
In reply to Re: TIANEPTINE Side effects, posted by Declan on January 18, 2007, at 13:38:42
hi Declan
thanks for the input. I'm hoping it'll work for me too :)
namaste,
lilith> I can understand people finding tianeptine anxiety producing. There was some nervous irritation from it.
> And maybe even a little constipation and weight gain (?), but if so not much.
>
> The nice thing with tianeptine was that I knew it would suit me from about Day 2 (at the latest).
> It's not perfect, but is easily the best AD I've tried.
> But my experience is only with Parnate, deprenyl, moclobemide, and Remeron (only 2 doses of that one).
Posted by liliths on January 21, 2007, at 10:18:50
In reply to Re: TIANEPTINE Side effects, posted by Declan on January 18, 2007, at 13:38:42
hi Declan - just checking whether you ever received my return babblemail - hope the info helped
namaste,
lilith> I can understand people finding tianeptine anxiety producing. There was some nervous irritation from it.
> And maybe even a little constipation and weight gain (?), but if so not much.
>
> The nice thing with tianeptine was that I knew it would suit me from about Day 2 (at the latest).
> It's not perfect, but is easily the best AD I've tried.
> But my experience is only with Parnate, deprenyl, moclobemide, and Remeron (only 2 doses of that one).
This is the end of the thread.
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