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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 20 of 20. This is the beginning of the thread.
Posted by linkadge on December 26, 2006, at 17:25:08
http://biopsychiatry.com/serotonin/gene.html
Linkadge
Posted by Phillipa on December 26, 2006, at 20:34:11
In reply to 5-ht1b autoreceptors in depressed mice, posted by linkadge on December 26, 2006, at 17:25:08
Link does this mean that this could be one of the reasons for my autoimmune diseases? The thyroid hasimotos now hyper? And that an SSRI is seen as foreign to my body and that's why they don't work? you have my e-mail now. Love Phillipa
Posted by linkadge on December 27, 2006, at 9:39:54
In reply to Re: 5-ht1b autoreceptors in depressed mice (nm), posted by linkadge on December 27, 2006, at 9:39:19
This is a little different.
Linkadge
Posted by Phillipa on December 27, 2006, at 17:23:42
In reply to Re: 5-ht1b autoreceptors in depressed mice, posted by linkadge on December 27, 2006, at 9:39:54
Link I know I don't have your brilliant brain but could you explain a little? Love Phillipa
Posted by linkadge on December 27, 2006, at 17:52:56
In reply to Re: 5-ht1b autoreceptors in depressed mice » linkadge, posted by Phillipa on December 27, 2006, at 17:23:42
Well, the serotonin autorecptors work as the gas pedal on serotonin release. When they are too sensitive, no serotonin gets released.
This study suggests that in depressed people, the autoreceptor are too sensitive, so serotonin release is low.
Antidepressnts appear to desensitize the autoreceptors and allow for more serotonin release. But not all antidepressants do this very well.
So a better drug would be one that can target the 5-ht1b autoreceptors more quickly and effectively.
Linkadge
Posted by Phillipa on December 27, 2006, at 19:54:26
In reply to Re: 5-ht1b autoreceptors in depressed mice, posted by linkadge on December 27, 2006, at 17:52:56
Link thanks wish they had a teaching board. So there are or aren't meds that do this? Thanks Phillipa ps check your mail
Posted by linkadge on December 27, 2006, at 21:25:05
In reply to Re: 5-ht1b autoreceptors in depressed mice » linkadge, posted by Phillipa on December 27, 2006, at 19:54:26
Well there are some meds in the pipelines that target this receptor. These meds will hopefully do more to test the hypothesis.
Linkadge
Posted by Phillipa on December 27, 2006, at 21:40:01
In reply to Re: 5-ht1b autoreceptors in depressed mice, posted by linkadge on December 27, 2006, at 21:25:05
Oh so they are not out yet. And you did check your mail? Love Phillipa
Posted by linkadge on December 27, 2006, at 22:04:13
In reply to Re: 5-ht1b autoreceptors in depressed mice » linkadge, posted by Phillipa on December 27, 2006, at 21:40:01
Yeah, I sent you an email... have you ever tried trazodone ?
Linkadge
Posted by Phillipa on December 27, 2006, at 23:11:31
In reply to Re: 5-ht1b autoreceptors in depressed mice, posted by linkadge on December 27, 2006, at 22:04:13
Link got it. Thanks. And no trazadone. I was given it once a long time ago but afraid to take it. Can you take it with valium? Just found out my pdoc appointment is the fourth. Any other meds you think might help? Love Phillipa
Posted by linkadge on December 28, 2006, at 9:56:05
In reply to Re: 5-ht1b autoreceptors in depressed mice » linkadge, posted by Phillipa on December 27, 2006, at 23:11:31
Definately ask about trazodone, this is a good med, and I am suprised you havn't taken it.
It can really help with sleep, I think its definatly worth a shot.
You may need to reduce you benzo's a wee bit, to prevent oversedation.
Let me know if you happen to go that route.
Linkadge
Posted by Phillipa on December 28, 2006, at 19:23:27
In reply to Re: 5-ht1b autoreceptors in depressed mice, posted by linkadge on December 28, 2006, at 9:56:05
Thanks Link you're a good person. Do you think trazadone will also work on depression and with the low dose luvox? Doubt oversedation with my high tolerance for benzos. Love Phillipa
Posted by linkadge on December 29, 2006, at 9:59:12
In reply to Re: 5-ht1b autoreceptors in depressed mice » linkadge, posted by Phillipa on December 28, 2006, at 19:23:27
Trazedone is an antidepressant, so it can help depression as well as sleep. I think trazedone would work fine with luvox, I don't see any interaction.
I can't make any promises of course, but I really think you should give it a shot. Its nothing you should be scared to try.
Linkadge
Posted by Cairo on December 30, 2006, at 10:18:48
In reply to Re: 5-ht1b autoreceptors in depressed mice, posted by linkadge on December 29, 2006, at 9:59:12
I used trazodone for years. It was weight neutral in me (yay!) and I felt a slight antidepressant effect and slept through the night. However, I still had sleep apnea and no stage 4 sleep and very little stage 3 sleep on it, so the quality of sleep was not improved by trazodone. And that was with Neurontin or Lyrica on board at the same time.
If sleep is a big issue, then I would advise a sleep study to determine the exact problem so an appropriate med can be prescribed. I'm trying low dose doxepin now to increase stage 4 sleep.
Good luck.
Cairo
> Trazedone is an antidepressant, so it can help depression as well as sleep. I think trazedone would work fine with luvox, I don't see any interaction.
>
> I can't make any promises of course, but I really think you should give it a shot. Its nothing you should be scared to try.
>
>
> Linkadge
>
>
>
Posted by linkadge on December 30, 2006, at 17:56:18
In reply to Re: Trazodone and sleep, posted by Cairo on December 30, 2006, at 10:18:48
How does doxepin affect sleep cycles?
Linkadge
Posted by deniseuk190466 on January 4, 2007, at 10:49:22
In reply to 5-ht1b autoreceptors in depressed mice, posted by linkadge on December 26, 2006, at 17:25:08
How long before they come up with a drug to do this do you think?
Denise
Posted by Denise190466 on January 10, 2007, at 14:22:34
In reply to 5-ht1b autoreceptors in depressed mice, posted by linkadge on December 26, 2006, at 17:25:08
How does this study relate to the one on P11 where they found that increasing this protein also increased the number of 5HT1B receptors on the cell surface.
Doesn't this study contradict the one on Pll. if the overactivy of 5HT1B receptors contributes to depression then wouldn't have more than one of them on the cell surface contribute to it as well. I mean wouldn't having lots of them equate to having an overactive 5HT1B system?
Also you mentioned drugs which are in the pipeline which might test this theory, which drugs are they and how soon will they be out?
How soon do you think it will be before they are manipulating genes in order to combat depression?
Denise
Posted by Cairo on March 2, 2007, at 20:47:02
In reply to Re: Trazodone and sleep » Cairo, posted by linkadge on December 30, 2006, at 17:56:18
> How does doxepin affect sleep cycles?
>
> LinkadgeI would still like to know if TCAs other than doxepin and amitriptyline affect stage 4 sleep as both these meds cause side effects in me. Thanks.
"In a pioneering study, Moldofsky and colleages (1975) were able to induce increased muscle stiffness and aching in normal volunteers by depriving them of delta sleep. Although the biochemical changes occurring during Stage 4 sleep remain poorly understood, a serotonergic connection does appear to be a key factor that promotes a restorative process in this stage of sleep (Moldofsky and Lue, 1980). This is perhaps why tricyclic antidepressants such as doxepin and amitriptyline, which promote an increase in the serotonin levels within the brain have shown therapeutic promise in the treatment of this syndrome."
And from Drugs.com:
"The mechanism of action of Sinequan (doxepin HCl) is not definitely known. It is not a central nervous system stimulant nor a monoamine oxidase inhibitor. The current hypothesis is that the clinical effects are due, at least in part, to influences on the adrenergic activity at the synapses so that deactivation of norepinephrine by reuptake into the nerve terminals is prevented. Animal studies suggest that doxepin HCl does not appreciably antagonize the antihypertensive action of guanethidine. In animal studies anticholinergic, antiserotonin and antihistamine effects on smooth muscle have been demonstrated. At higher than usual clinical doses, norepinephrine response was potentiated in animals. This effect was not demonstrated in humans.
At clinical dosages up to 150 mg per day, Sinequan can be given to man concomitantly with guanethidine and related compounds without blocking the antihypertensive effect. At dosages above 150 mg per day blocking of the antihypertensive effect of these compounds has been reported."
Cairo
Posted by Cairo on March 2, 2007, at 21:03:42
In reply to Re: Trazodone and sleep » Cairo, posted by linkadge on December 30, 2006, at 17:56:18
> How does doxepin affect sleep cycles?
>
> LinkadgeHere's a better article; see page 122:
http://www.psychiatrist.com/pcc/pccpdf/v03n03/v03n0303.pdf
Cairo
Posted by JohnnyBLinux on March 3, 2007, at 9:55:51
In reply to Re: Trazodone and sleep, posted by Cairo on December 30, 2006, at 10:18:48
I need to use Trazadone as-needed for sleep, otherwise it stops working after a week of continuous use.
This is the end of the thread.
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