Posted by linkadge on December 27, 2006, at 17:52:56
In reply to Re: 5-ht1b autoreceptors in depressed mice » linkadge, posted by Phillipa on December 27, 2006, at 17:23:42
Well, the serotonin autorecptors work as the gas pedal on serotonin release. When they are too sensitive, no serotonin gets released.
This study suggests that in depressed people, the autoreceptor are too sensitive, so serotonin release is low.
Antidepressnts appear to desensitize the autoreceptors and allow for more serotonin release. But not all antidepressants do this very well.
So a better drug would be one that can target the 5-ht1b autoreceptors more quickly and effectively.
Linkadge
poster:linkadge
thread:716561
URL: http://www.dr-bob.org/babble/20061224/msgs/716757.html