Psycho-Babble Medication Thread 715838

Shown: posts 1 to 16 of 16. This is the beginning of the thread.

 

rosa63...Amisulpride

Posted by blueberry1 on December 23, 2006, at 9:38:57

Hi Rosa63,
I wanted to comment on your question about amisulpride but I didn't want to go off subject in the previous thread.

Is Amisulpride a miracle drug? Unfortunately no. In clinical trials it has about the same response as other drugs, generally in the 60% range. It is especially good if you suspect hypodopamine function, either as an underlying condition or as a result of a serotonin antidepressant.

If it works what it does is decrease depression, decrease anxiety, increase pleasure, increase interest, increase motivation, increase social comfort. It works by a unique mechanism of targeting dopamine in a very specific way that no other drug on the planet does. It is called an antipsychotic, but it doesn't act like one at low doses.

How to get it? Well, Dr Bob prohibits giving out sources of non-FDA drugs. All I can say is do a search on buy solian, or buy deniban. Over the last 10 years I have purchased it from Europe, from Panama, and from an escrow service in Canada. The best bet is to buy 200mg tabs and then break them into quarters. That makes the $200 purchase last about a year.

Disclaimer: Due to fake meds, low quality meds, and fraud, it is not safe to buy drugs over the internet from other countries. But I've never had any problems.

 

Re: rosa63...Amisulpride » blueberry1

Posted by rosa63 on December 23, 2006, at 11:21:44

In reply to rosa63...Amisulpride, posted by blueberry1 on December 23, 2006, at 9:38:57


>
> Disclaimer: Due to fake meds, low quality meds, and fraud, it is not safe to buy drugs over the internet from other countries. But I've never had any problems.

ROFL!! :) Is Amisulpride safe to take with: Cymbalta, Wellbutrin, Abilify, Klonopin, and Trazodone? And, IF I were to request that my pdoc write me a script to send to Canada legally, how much would I ask him to start me out with? 50 mg a day?

 

Re: rosa63...Amisulpride » rosa63

Posted by ronaldo on December 23, 2006, at 11:50:57

In reply to Re: rosa63...Amisulpride » blueberry1, posted by rosa63 on December 23, 2006, at 11:21:44

This might be helpful:

http://services.ascribe.com/bnf/publications.aspx/bnf/current/index.htm

ronaldo

 

Re: rosa63...Amisulpride » rosa63

Posted by blueberry1 on December 23, 2006, at 12:47:32

In reply to Re: rosa63...Amisulpride » blueberry1, posted by rosa63 on December 23, 2006, at 11:21:44

>
> >
> > Disclaimer: Due to fake meds, low quality meds, and fraud, it is not safe to buy drugs over the internet from other countries. But I've never had any problems.
>
> ROFL!! :) Is Amisulpride safe to take with: Cymbalta, Wellbutrin, Abilify, Klonopin, and Trazodone? And, IF I were to request that my pdoc write me a script to send to Canada legally, how much would I ask him to start me out with? 50 mg a day?

The common dose is 50mg, in a range of 25mg to 100mg. At 150mg it starts acting more like an antipsychotic. To put it in perspective, schizophrenia doses are 400mg-800mg.

It is a good add-on to antidepressants and benzos. It has been added to other antipsychotics for increased effectiveness. Compared to other antipsychotics, risks and side effects are very low.

It might be tough getting your psychiatrist to go along with it. You might have to print up every research report you can find on google to back up your request. But even then, he might have other reasons for not going along with (i.e. malpractice insurance - nonFDA drug).

 

Amisulpride - lots of hype!

Posted by jimmygold70 on December 23, 2006, at 16:06:05

In reply to rosa63...Amisulpride, posted by blueberry1 on December 23, 2006, at 9:38:57

Sorry to say, but amisulpride offers little, if anything, over other low-potency antipsychotics. I know a PDoc who made a long case series with it and saw only side effect and NOT A SINGLE SUCCESS CASE. I see no logical reason why it should offer anything beyond those low potency APs, e.g. chlorpromazine.

Indeed, therre are nice clinical trials out there but these are all of low quality. Show me a research in the Lancet, NEJM or Archives of general psychiatry that it does make a difference (-:

 

Re: rosa63...Amisulpride » blueberry1

Posted by Quintal on December 23, 2006, at 16:29:12

In reply to Re: rosa63...Amisulpride » rosa63, posted by blueberry1 on December 23, 2006, at 12:47:32

>Compared to other antipsychotics, risks and side effects are very low.

Blueberry, I don't mean to nitpick but I remember you saying very recently that you decided to quit amisulpride because of sexual dysfunction, which was you described as severe, and insomnia. I'm curious why you've now decided to give it a re-trial? Do you have a strategy in mind for lowering or preventing elevated prolactin or something?

Q

 

Re: Amisulpride - lots of hype? » jimmygold70

Posted by Quintal on December 23, 2006, at 16:42:01

In reply to Amisulpride - lots of hype!, posted by jimmygold70 on December 23, 2006, at 16:06:05

Have you actually tried amisulpride jimmygold70? Both blueberry and I have and for me at least amisulpride was very different from other low-dose antipsychotics. There is good reason to think low dose amisulpride would be different from other antipsychotics because it *enhances* dopaminergic transmission. This gives amisulpride a different profile to other antipsychotics which are mostly dopamine antagonists across the dose range - Abilify is partial agonist at D2 receptors.

I appreciate your point of view, but that was a very strong statement with little to support it. Please try not to make other people feel put down.

Q

 

Re: Amisulpride - lots of hype!

Posted by blueberry1 on December 23, 2006, at 17:51:35

In reply to Amisulpride - lots of hype!, posted by jimmygold70 on December 23, 2006, at 16:06:05

I appreciate your opinions. I could easily debate each point, but this site is for information and support. Information I share is openly available from 4 sources...pubmed.org, remedyfind.com, real life experiences of others here, and my own experiences. But not from any single doctor's case study.

Amisulpride in my own experience and in the experience of others seems best when used in combination with something else rather than alone. That's just opinion from observation.

Have you ever tried amisulpride? I have. Others here have. Oddly, our experiences differ a lot from the case study you referred to. Results against placebo, prozac, paxil, and amineptine also differ a lot from that case study.

Do you understand it enhances dopamine transmission instead of blocking it? It is interesting how it differs from any drug in its class, i.e. presynaptic D2 D3 blockade only, no post synaptic blockade, focus on mesolimbic pleasure center.

I'm sorry you took the post as hype. It wasn't meant to be that way. Someone was interested and I was trying to share information and support.

 

Thank you for all your responses!!! (nm)

Posted by rosa63 on December 24, 2006, at 6:31:24

In reply to Re: Amisulpride - lots of hype!, posted by blueberry1 on December 23, 2006, at 17:51:35

 

Sorry. Forget what I've written!

Posted by jimmygold70 on December 24, 2006, at 7:46:47

In reply to rosa63...Amisulpride, posted by blueberry1 on December 23, 2006, at 9:38:57

It's my Zyprexa withdrawal writing. It makes me very impulsive and rude sometimes. I should have communicated my message in a different way, if at all. Sorry if anyone was hurt.

I've tried Amisulpride on its market introduction. I gave it lots of chances – all kinds of doses for reasonable times. Maybe 4 months of experimentation. While in theory it should be a presynaptic dopamine antagonist in low doses, which in theory raises dopamine, it didn't really do anything interesting in my case. It raised my prolactin levels to sky high in doses as low as 12.5 MG, which is certainly a sign of postsynaptic antagonism. We used to have sulpiride (which I know people refer to as different) form many years in my country. I had the very same experience with it. So I cannot tell the difference between the two and between amisulpride and any other low-potency AP. This is my very personal account, of course.

Now there was a very nice research published recently (forgot the exact citation) that incidentally showed that physicians and patients eventually prefer sulpiride over many other APs. It might be a well-tolerated AP for some – but I'm talking about high, antagonistic doses.

What I referred to as hype wasn't directed at any particular posting but rather to much published research showing spectacular results which I have not seen replicable in clinical practice. It might work for some people, I have no way of arguing with "I" statements. What I feel is that my personal experimentation with amisulpride and hence others might result in disappointment, when more well established agents might have done a more proper job. Of course, this is very individual and my own views might be seen as somewhat conservative, but as far as amisulpride is involved I would rather put it in the Nth line where N is high.

Again, sorry if I've hurt anybody and I might and may still appear as rude. I'll be happy to hear comments about how people would pharmacologically and non-pharmacologically cope with symptoms such as mine that might result from Zyprexa withdrawal but I think it's more like simply me without the Zyprexa and with the disorder.

Thanks for you help and patience. Special thanks to Quintal and Blueberry1 for putting me back on track.

Jimmy


 

Re: Amisulpride

Posted by laima on December 24, 2006, at 12:04:05

In reply to rosa63...Amisulpride, posted by blueberry1 on December 23, 2006, at 9:38:57


This is an interesting and unique sounding drug. Do I gather it's not available in the US? Why? Will it be?

Thanks.

 

Re: Amisulpride » laima

Posted by Quintal on December 24, 2006, at 15:31:56

In reply to Re: Amisulpride, posted by laima on December 24, 2006, at 12:04:05

>This is an interesting and unique sounding drug. Do I gather it's not available in the US? Why? Will it be?

Amisulpride is a unique drug but I doubt it will ever be on sale in the US for similar reasons that tianeptine et al may never be licensed - it's too expensive to approve a drug on which the patent has expired. There's also suspicion and hostility among some American pdocs about European psychopharmacology.

You can import it legally with a pdoc's prescription though, and there are other ways obviously.

Q

 

Re: Sorry. Forget what I've written!

Posted by blueberry1 on December 24, 2006, at 15:44:05

In reply to Sorry. Forget what I've written!, posted by jimmygold70 on December 24, 2006, at 7:46:47

Hey jimmygold, I really enjoy reading your posts. I'm not going to forget what you've written, because I like to see the whole picture and you have some valid points that need to be in that picture. Amisulpride didn't work for that doctor's case study and it didn't work for you. That is meaningful in the big picture. Thank you for sharing that.

I think one thing that deserves mention in the whole amisulpride discussion is this...in my opinion I think it is much better as an add-on medication to something else. For example if someone is on an ssri, they are not feeling particularly depressed but they are feeling blah and pleasureless, amisulpride can work great in that situation. Or with a benzo. Or if they are stable on meds but still have difficulty being comfortable in a crowd. It adds a specific dopamine component to balance things out, especially if someone wants avoid messing with serotonin norepinephrine and histimine. If they just want pure dopamine, amisulpride can add that balance I think. At least it did for me anyway.

I have never tried amisulpride on its own. It was an awesome add-on to prozac. But that prolactin thing. Strange how that happens to some people but not others. There was someone else here a couple weeks ago that got his sky-high prolactin back to normal by taking cabergoline twice a week and reducing the amisulpride dose from 50mg to 25mg.

 

Re: Amisulpride » laima

Posted by blueberry1 on December 24, 2006, at 15:46:37

In reply to Re: Amisulpride, posted by laima on December 24, 2006, at 12:04:05

>
> This is an interesting and unique sounding drug. Do I gather it's not available in the US? Why? Will it be?
>
> Thanks.

It is kind of unique. It is available in the US only by mailorder from overseas. I doubt the company that makes it will spend the millions of dollars it takes to get through the FDA process. Every now and then I hear rumors that they are working on it, but I doubt it. Too bad.

 

Re: Amisulpride

Posted by laima on December 26, 2006, at 12:37:53

In reply to Re: Amisulpride » laima, posted by blueberry1 on December 24, 2006, at 15:46:37

Thanks Quintal and Blueberry for information. It's a real shame that this drug isn't available in the US, and it's upsetting to me about how politics and quest for profit get mixed up into medicine- I'm a bit skittish to try on my own right at this time. (But who knows in the future...)


> >
> > This is an interesting and unique sounding drug. Do I gather it's not available in the US? Why? Will it be?
> >
> > Thanks.
>
> It is kind of unique. It is available in the US only by mailorder from overseas. I doubt the company that makes it will spend the millions of dollars it takes to get through the FDA process. Every now and then I hear rumors that they are working on it, but I doubt it. Too bad.
>
>

 

Re: Amisulpride/Prolactin/Blueberry

Posted by stargazer on December 27, 2006, at 23:06:56

In reply to Re: Amisulpride » laima, posted by blueberry1 on December 24, 2006, at 15:46:37

Hi, I'm trying to understand the effect on the Prolactin level. What causes it and what are the symptoms of a high Prolactin level. What happens if the level stays high. Is this something that has to be monitored the whole time you take Amisulpride and do the pdocs know about this side effect since it is not routinely used...SG


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