Posted by jimmygold70 on December 24, 2006, at 7:46:47
In reply to rosa63...Amisulpride, posted by blueberry1 on December 23, 2006, at 9:38:57
It's my Zyprexa withdrawal writing. It makes me very impulsive and rude sometimes. I should have communicated my message in a different way, if at all. Sorry if anyone was hurt.
I've tried Amisulpride on its market introduction. I gave it lots of chances – all kinds of doses for reasonable times. Maybe 4 months of experimentation. While in theory it should be a presynaptic dopamine antagonist in low doses, which in theory raises dopamine, it didn't really do anything interesting in my case. It raised my prolactin levels to sky high in doses as low as 12.5 MG, which is certainly a sign of postsynaptic antagonism. We used to have sulpiride (which I know people refer to as different) form many years in my country. I had the very same experience with it. So I cannot tell the difference between the two and between amisulpride and any other low-potency AP. This is my very personal account, of course.
Now there was a very nice research published recently (forgot the exact citation) that incidentally showed that physicians and patients eventually prefer sulpiride over many other APs. It might be a well-tolerated AP for some – but I'm talking about high, antagonistic doses.
What I referred to as hype wasn't directed at any particular posting but rather to much published research showing spectacular results which I have not seen replicable in clinical practice. It might work for some people, I have no way of arguing with "I" statements. What I feel is that my personal experimentation with amisulpride and hence others might result in disappointment, when more well established agents might have done a more proper job. Of course, this is very individual and my own views might be seen as somewhat conservative, but as far as amisulpride is involved I would rather put it in the Nth line where N is high.
Again, sorry if I've hurt anybody and I might and may still appear as rude. I'll be happy to hear comments about how people would pharmacologically and non-pharmacologically cope with symptoms such as mine that might result from Zyprexa withdrawal but I think it's more like simply me without the Zyprexa and with the disorder.
Thanks for you help and patience. Special thanks to Quintal and Blueberry1 for putting me back on track.
Jimmy
poster:jimmygold70
thread:715838
URL: http://www.dr-bob.org/babble/20061224/msgs/716094.html