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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by chiron on December 10, 2006, at 19:20:59
Has anyone experienced this? My body is so bizarre.
Posted by Phillipa on December 10, 2006, at 19:56:44
In reply to Seroquel causing agitation?, posted by chiron on December 10, 2006, at 19:20:59
What else are you taking and what is your diagnosis. It does sound strange. But I'm strange too. Love Phillipa
Posted by med_empowered on December 10, 2006, at 22:03:35
In reply to Re: Seroquel causing agitation? » chiron, posted by Phillipa on December 10, 2006, at 19:56:44
yup. It happened to me @ 100mgs. I don't think its all that uncommon..I think docs just *assume* it is, since seroquel is so over-hyped, and its "atypical" and therefore completely magical.
Seroquel blocks dopamine. Dopamine blockers can induce or worsen agitation and psychosis. Since seroquel has been linked to tardive dyskinesia, we know that it isn't all that aytpical after all, so even with all the serotonin antagonism and what not what you're really looking at is a souped-up Thorazine.
Good luck.
Posted by chiron on December 11, 2006, at 7:49:36
In reply to Re: Seroquel causing agitation?, posted by med_empowered on December 10, 2006, at 22:03:35
> yup. It happened to me @ 100mgs. I don't think its all that uncommon..I think docs just *assume* it is, since seroquel is so over-hyped, and its "atypical" and therefore completely magical.
>
> Seroquel blocks dopamine. Dopamine blockers can induce or worsen agitation and psychosis. Since seroquel has been linked to tardive dyskinesia, we know that it isn't all that aytpical after all, so even with all the serotonin antagonism and what not what you're really looking at is a souped-up Thorazine.
>
Thank you Med Empowered. Where did you learn all of your stuff?
Posted by yxibow on December 12, 2006, at 23:43:33
In reply to Re: Seroquel causing agitation?, posted by med_empowered on December 10, 2006, at 22:03:35
> yup. It happened to me @ 100mgs. I don't think its all that uncommon..I think docs just *assume* it is, since seroquel is so over-hyped, and its "atypical" and therefore completely magical.
>
> Seroquel blocks dopamine. Dopamine blockers can induce or worsen agitation and psychosis. Since seroquel has been linked to tardive dyskinesia, we know that it isn't all that aytpical after all, so even with all the serotonin antagonism and what not what you're really looking at is a souped-up Thorazine.
Its akathisia, most likely, as you say -- but akathisia is still rare on Seroquel (as I can attest that only Zyprexa and Seroquel do not give me akathisia and I am sensitive -- of course, needless to say, everyone is different) and even more rare on Clozaril (other unpleasant side effects on the other hand are more and harder to manage with Clozaril). Also TD, while some reports have occurred, is also generally more rare on Seroquel than say, Risperdal. One journal report put a statistical average about 2% for TD across the board for atypicals. Another I've seen with a larger number of patients is about 1/2% annually for Zyprexa (British Journal of Psychiatry 174: 23-30 (1999). Its not like Haldol by any means, especially EPS, since EPS and TD are somewhat on a continuum.-- Jay
Posted by stargazer on December 13, 2006, at 9:30:01
In reply to Re: Seroquel causing agitation? » med_empowered, posted by yxibow on December 12, 2006, at 23:43:33
It's like another condition called NMS, Neuroleptic Malignant syndrome. If someone is given Haldol when they are taking Sinemet, a med for Parkinson's, which increases dopamine, it can trigger this condition which can be fatal.
They did this to my father when he was in the ER at Yale. He was restless and writhing from too much Sinemet (akinesisa) and they gave him Haldol which blocks dopamine.
I got to the ER after this was already done. I felt his arm and he was burning up. I asked the docs what they gave him and asked the nurse to take his temp, which was about 105.
Needless to say, after these questions, they pulled him into a private room and really started to listen to me. I told them he might have NMS since he shouldn't have gotten Haldol with Sinemet. They looked at me funny and then a lightbulb went on in their heads...
Moral of that story...anyone on dopamine agonists drugs, like Sinemet and probably many others should never be given Haldol no matter how agitated they are....NMS can be fatal if not caught in time.
Remember that was at Yale, one of the ten top psych hospitals in the country, not at Little Country Hospital.
SG
Posted by Phillipa on December 13, 2006, at 17:58:16
In reply to Re: Seroquel causing agitation? Similar condition, posted by stargazer on December 13, 2006, at 9:30:01
Yale is where my Mother died in the 60's. She was on bedrest and had a cough. They were going to x-ray her lungs in the am. During the night she threw a pulmonary embolism and died. No Homan's signs? And my youngest was there in neonatal ICU cause the docs had let me take benzos and alchohol during pregnancy. She projectile vomited till l8 months and cried 24 hours a day. They thought it was failure to thrive. She was there two weeks and the nurses didn't put any weight on her. Sent her home with him saying not one person alone could care for her. In the two weeks she was there I cold turkeyed from all meds and felt like I was on a rocking ship. So I added back 5mg of valium and was able to relax and put three pounds on her in a month. God so many things. Love Phillipa ps the docs including the OB-GYN knew about the meds and they even gave me two seconals in false labor two weeks before she was born.
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