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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by ronaldo on November 30, 2006, at 10:15:31
http://www.worldhealth.net/p/1010,2048.htmlADRAFINIL AND MODAFINIL COMPARED
At first glance there may appear to be little difference between the two. It is true that modafinil is more potent, “average” doses of adrafinil are in the region of 600mg to 1200mg daily, compared to modafinil’s 200mg to 400mg daily and this is self evident by the respective tablet sizes.
However, if one were to compare adrafinil and modafinil on price alone then adrafinil would win hands down! So the question must be asked, why did Lafon produce a newer analogue of adrafinil?
The answer probably lies in two parts. Firstly, it is thought that adrafinil may not be such a highly selective alpha-1 adrenergic as originally thought and may also affect other alpha receptors, (albeit in a minute fashion).
Secondly, adrafinil is attributed to some other possible side effects that have not been associated (to date) with modafinil, including, stomach pain, skin irritations, inner tension and in long term use, (over 3 months usually), an increase in liver enzyme levels, (which is reversible by reduction or withdrawal). It is our guess that it is the last potential side effect that lead to the development of modafinil. Clearly, continuous adrafinil use would require regular blood testing to monitor liver enzyme levels, and this is obviously inconvenient to those patients who need to use eugeroics on a regular basis.
As none of the clinical reports we have read indicate any such problem with modafinil, it would appear that the analogue has achieved its desired aim.
Posted by zmg on November 30, 2006, at 11:56:01
In reply to Adrafinil and Modafinil Compared, posted by ronaldo on November 30, 2006, at 10:15:31
Ronaldo,
Do you have any qualitative experience with the two? I'm pretty sure you're right about the liver enzymes. From what I've read people taking Adrafinil should have regular check ups (at least twice a year) to test for liver problems.But I've also read that Adrafinil had more pronounced antidepressant effects?
I plan to talk to my doctor about Modafinil ASAP but I've placed an order for Adrafinil this week. If he agrees Modafinil might be helpful I can probably compare the two myself, at the very least I'd like to get checked out anyway. I'm sure my livers already been doing more work then it would like.
- Zach
Posted by Crazy Horse on November 30, 2006, at 12:17:57
In reply to Re: Adrafinil and Modafinil Compared » ronaldo, posted by zmg on November 30, 2006, at 11:56:01
> But I've also read that Adrafinil had more pronounced antidepressant effects?
Yea, i have read this myself..i believe it was at remedyfind.-MJ
Posted by ronaldo on November 30, 2006, at 12:22:42
In reply to Re: Adrafinil and Modafinil Compared » ronaldo, posted by zmg on November 30, 2006, at 11:56:01
> Ronaldo,
> Do you have any qualitative experience with the two? I'm pretty sure you're right about the liver enzymes. From what I've read people taking Adrafinil should have regular check ups (at least twice a year) to test for liver problems.
>
> But I've also read that Adrafinil had more pronounced antidepressant effects?>
> I plan to talk to my doctor about Modafinil ASAP but I've placed an order for Adrafinil this week. If he agrees Modafinil might be helpful I can probably compare the two myself, at the very least I'd like to get checked out anyway. I'm sure my livers already been doing more work then it would like.
>
> - ZachHi Zach
Like you I have just placed my first order for Adrafinil. All I know is what I can find on the internet. Unfortunately I have to wean myself off Zyprexa first so I will only be starting Olmifon end of January next year. I will be very interested to hear about your experiences with Adrafinil/Olmifon. Please babble mail me if you don't post to the board.
I think the 'expert' babbler on Adrafinil has to be blueberry who I believe has used it successfully for a few years.
....ronaldo
Posted by zmg on November 30, 2006, at 13:33:37
In reply to Re: Adrafinil and Modafinil Compared » zmg, posted by ronaldo on November 30, 2006, at 12:22:42
Thanks Ronaldo. I'll be sure to post my experience, hopefully with both.
This is the end of the thread.
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