Posted by ronaldo on November 30, 2006, at 10:15:31
http://www.worldhealth.net/p/1010,2048.htmlADRAFINIL AND MODAFINIL COMPARED
At first glance there may appear to be little difference between the two. It is true that modafinil is more potent, “average” doses of adrafinil are in the region of 600mg to 1200mg daily, compared to modafinil’s 200mg to 400mg daily and this is self evident by the respective tablet sizes.
However, if one were to compare adrafinil and modafinil on price alone then adrafinil would win hands down! So the question must be asked, why did Lafon produce a newer analogue of adrafinil?
The answer probably lies in two parts. Firstly, it is thought that adrafinil may not be such a highly selective alpha-1 adrenergic as originally thought and may also affect other alpha receptors, (albeit in a minute fashion).
Secondly, adrafinil is attributed to some other possible side effects that have not been associated (to date) with modafinil, including, stomach pain, skin irritations, inner tension and in long term use, (over 3 months usually), an increase in liver enzyme levels, (which is reversible by reduction or withdrawal). It is our guess that it is the last potential side effect that lead to the development of modafinil. Clearly, continuous adrafinil use would require regular blood testing to monitor liver enzyme levels, and this is obviously inconvenient to those patients who need to use eugeroics on a regular basis.
As none of the clinical reports we have read indicate any such problem with modafinil, it would appear that the analogue has achieved its desired aim.
poster:ronaldo
thread:708958
URL: http://www.dr-bob.org/babble/20061129/msgs/708958.html