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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by iforgotmypassword on September 22, 2006, at 14:55:54
I am wondering about this "A1 allele of DRD2 Taq1A polymorphism". I got extremely bad akithisia, jerks, shivers, and even mouth movements from Paxil and company. I still get them sometimes now. I also got noticably better NOT WORSE when I finally dropped it cold-turkey, which I believe indicates a cholinergic mechanism, right?
In any case is there anything that can be tested that would steer things in the right direction or at least give me something to keep my eye on until medical discoveries or what not start to magically surface?
Posted by yxibow on September 22, 2006, at 19:56:20
In reply to can you get your genes tested for anything yet?, posted by iforgotmypassword on September 22, 2006, at 14:55:54
> I am wondering about this "A1 allele of DRD2 Taq1A polymorphism". I got extremely bad akithisia, jerks, shivers, and even mouth movements from Paxil and company. I still get them sometimes now. I also got noticably better NOT WORSE when I finally dropped it cold-turkey, which I believe indicates a cholinergic mechanism, right?
>
> In any case is there anything that can be tested that would steer things in the right direction or at least give me something to keep my eye on until medical discoveries or what not start to magically surface?
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16633151&query_hl=12&itool=pubmed_docsum
Gene testing is very expensive and generally reserved for research unfortunately at this point in time, except for the P450 Amplichip, which is cutting edge technology and not generally covered by insurance.SSRIs, as you experienced, do rarely cause EPS -- this is probably dose related and probably vary by the SSRI used. Zoloft is more often implicated because of its brushover on some dopamine receptors.
Posted by Phillipa on September 22, 2006, at 21:55:35
In reply to Re: can you get your genes tested for anything yet » iforgotmypassword, posted by yxibow on September 22, 2006, at 19:56:20
Jay what does that mean about zoloft? Everyone I know is on it. Love Jan
Posted by yxibow on September 23, 2006, at 2:33:14
In reply to Re: can you get your genes tested for anything yet » yxibow, posted by Phillipa on September 22, 2006, at 21:55:35
> Jay what does that mean about zoloft? Everyone I know is on it. Love Jan
It has from what I have heard from my doctor the only known case of TD from Zoloft in his practice due probably to a slightly higher propensity for some of the dopamine receptors. This only occurs at high doses (over 300mg).
(citation)
http://en.wikipedia.org/wiki/Sertraline
-- Jay
Posted by linkadge on September 23, 2006, at 16:26:19
In reply to Re: high dose Zoloft » Phillipa, posted by yxibow on September 23, 2006, at 2:33:14
Hmm, I was under the impression that zoloft was less likely to cause TD/akathesia since its DRI would lesson serotonin uptake inhibition induced dopamine depletion.
I don't think that the word "rare" is really sufficiant.
I would never report some effects like say, jaw clenching, and significant worsening of cursive to a doctor, but they are milder forms of the same thing.
Linkadge
Posted by yxibow on September 23, 2006, at 16:41:46
In reply to Re: high dose Zoloft, posted by linkadge on September 23, 2006, at 16:26:19
> Hmm, I was under the impression that zoloft was less likely to cause TD/akathesia since its DRI would lesson serotonin uptake inhibition induced dopamine depletion.
>
> I don't think that the word "rare" is really sufficiant.
>
> I would never report some effects like say, jaw clenching, and significant worsening of cursive to a doctor, but they are milder forms of the same thing.
>
> Linkadge
I'm not following the never reporting effects..But EPS and dyskinesias are just as possible with Risperdal as Sinemet.
Posted by linkadge on September 23, 2006, at 21:08:53
In reply to Re: high dose Zoloft » linkadge, posted by yxibow on September 23, 2006, at 16:41:46
I guess I was just arguing that milder versions of SSRI induced EPS likely occur more often than rarely.
Linkadge
Posted by yxibow on September 23, 2006, at 23:05:22
In reply to Re: high dose Zoloft, posted by linkadge on September 23, 2006, at 21:08:53
> I guess I was just arguing that milder versions of SSRI induced EPS likely occur more often than rarely.
>
> LinkadgeAh okay ... yes, they do... as do priapisms on Trazodone I can attest, but they are still in the "rare" category which usually means less than 1 in 100. And it is most likely dosal related.
Posted by linkadge on September 24, 2006, at 10:11:52
In reply to Re: high dose Zoloft » linkadge, posted by yxibow on September 23, 2006, at 23:05:22
>I can attest, but they are still in the "rare" >category which usually means less than 1 in 100
My second point was that, "rare" is a medical term used to denote the *reported* cases of an event. It may or may not accurately quanitify the problem.
Linkadge
Posted by yxibow on September 24, 2006, at 21:14:48
In reply to Re: high dose Zoloft, posted by linkadge on September 24, 2006, at 10:11:52
> >I can attest, but they are still in the "rare" >category which usually means less than 1 in 100
>
> My second point was that, "rare" is a medical term used to denote the *reported* cases of an event. It may or may not accurately quanitify the problem.
>
> LinkadgeExactly, I wasn't arguing. There are always unreported "Phase IV" issues. The FDA encourages drug reports and I'm sure EMEA does too, but not everything gets reported, for a variety of reasons, including that people still want a medication on the market for their symptoms even if the side effects are unpleasant as it is the only thing out there. (Just a guess.)
Posted by Zoloft Birth Defects on September 1, 2011, at 13:33:18
In reply to Re: high dose Zoloft » Phillipa, posted by yxibow on September 23, 2006, at 2:33:14
This drug turned out more dangerous than expected. Here are some resources: http://www.zoloftbirthdefectlawyer.com/
This is the end of the thread.
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