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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by janeB on August 15, 2006, at 22:38:38
I never heard that prozac was derived from diphenhydramine! So if prozac is supposed to be energizing why is it making me so tired? I found this possible explanation. Benadryl knocks me out. Does Benadryl=Prozac?
http://en.wikipedia.org/wiki/Fluoxetine
"Fluoxetine was derived from diphenhydramine, an antihistamine found to inhibit reuptake of the neurotransmitter serotonin.Compared to other popular selective serotonin reuptake inhibitors (SSRIs), fluoxetine has a strong energizing effect."
If prozac doesn't energize me what will?
Jane
Posted by Phillipa on August 15, 2006, at 23:00:41
In reply to Interesting finding. Is it correct?, posted by janeB on August 15, 2006, at 22:38:38
Benadryl? heck when it first came out it cause horrible panic attacks on day three and I wasn't having them then. Love Phillipa
Posted by janeB on August 16, 2006, at 8:34:09
In reply to Re: Interesting finding. Is it correct? » janeB, posted by Phillipa on August 15, 2006, at 23:00:41
What caused panic attacks--benadryl or prozac? Thanks for answering. Jane
> Benadryl? heck when it first came out it cause horrible panic attacks on day three and I wasn't having them then. Love Phillipa
Posted by silvercoin on August 16, 2006, at 8:37:21
In reply to Interesting finding. Is it correct?, posted by janeB on August 15, 2006, at 22:38:38
> I never heard that prozac was derived from diphenhydramine! So if prozac is supposed to be energizing why is it making me so tired? I found this possible explanation. Benadryl knocks me out. Does Benadryl=Prozac?
>
> http://en.wikipedia.org/wiki/Fluoxetine
> "Fluoxetine was derived from diphenhydramine, an antihistamine found to inhibit reuptake of the neurotransmitter serotonin.
>
> Compared to other popular selective serotonin reuptake inhibitors (SSRIs), fluoxetine has a strong energizing effect."
>
> If prozac doesn't energize me what will?
> Jane
The structures are relatively similar in the grand scheme of things, but probably not so much that you can associate adverse effects of one drug with the other. Several of the tricyclics have more similar structures than these two drugs but differ widely in their side effects. I personally find Benadryl to make me drowsy, but Prozac is almost unbearably activating.Todd
Posted by djmmm on August 16, 2006, at 13:32:23
In reply to Interesting finding. Is it correct?, posted by janeB on August 15, 2006, at 22:38:38
> I never heard that prozac was derived from diphenhydramine! So if prozac is supposed to be energizing why is it making me so tired? I found this possible explanation. Benadryl knocks me out. Does Benadryl=Prozac?
>
> http://en.wikipedia.org/wiki/Fluoxetine
> "Fluoxetine was derived from diphenhydramine, an antihistamine found to inhibit reuptake of the neurotransmitter serotonin.
>
> Compared to other popular selective serotonin reuptake inhibitors (SSRIs), fluoxetine has a strong energizing effect."
>
> If prozac doesn't energize me what will?
> JaneI think that "derived from diphenhydramine" means that it (prozac) was developed from the research associated with the development of histamine blockers (since histamine is closely related to serotonin) Many antihistamines are potent SSRIs, and many SSRIs are potent antihistamines....
I believe the antihistamine Brompheniramine was first developed, which led to the development of the antihistamine chlorpheniramine, which was found to be a potent SSRI, through this, a drug called Zimelidine (the very first SSRI) was developed, and then removed from the market. Fluvoxamine (luvox) was then developed by Solvay, followed by lilly's Prozac.
Posted by Darwin on August 16, 2006, at 18:09:44
In reply to Interesting finding. Is it correct?, posted by janeB on August 15, 2006, at 22:38:38
Prozac is not energizing for everyone. For me, Prozac was sedating. After 6 weeks on Prozac, my sleep time had increased from about 7 hours to 10 hours a day and I felt like a zombie when I was awake. So I quit Prozac.
I recall reading a comment by a doctor who said that if Prozac is very sedating rather than stimulating for a patient, it probably is the wrong antidepressant for that patient.
Prozac may have been derived from an antihistamine but it is not an antihistamine. So its sedating properties are not due to antihistamic effects.
Darwin
Posted by janeB on August 18, 2006, at 23:57:59
In reply to Re: Interesting finding. Is it correct? » janeB, posted by Darwin on August 16, 2006, at 18:09:44
Darwin,
I think I agree that prozac is probably not the AD for me. It makes me too tired! Thanks for your response. Jane> Prozac is not energizing for everyone. For me, Prozac was sedating. After 6 weeks on Prozac, my sleep time had increased from about 7 hours to 10 hours a day and I felt like a zombie when I was awake. So I quit Prozac.
>
> I recall reading a comment by a doctor who said that if Prozac is very sedating rather than stimulating for a patient, it probably is the wrong antidepressant for that patient.
>
> Prozac may have been derived from an antihistamine but it is not an antihistamine. So its sedating properties are not due to antihistamic effects.
>
> Darwin
>
>
>
>
This is the end of the thread.
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