Posted by djmmm on August 16, 2006, at 13:32:23
In reply to Interesting finding. Is it correct?, posted by janeB on August 15, 2006, at 22:38:38
> I never heard that prozac was derived from diphenhydramine! So if prozac is supposed to be energizing why is it making me so tired? I found this possible explanation. Benadryl knocks me out. Does Benadryl=Prozac?
>
> http://en.wikipedia.org/wiki/Fluoxetine
> "Fluoxetine was derived from diphenhydramine, an antihistamine found to inhibit reuptake of the neurotransmitter serotonin.
>
> Compared to other popular selective serotonin reuptake inhibitors (SSRIs), fluoxetine has a strong energizing effect."
>
> If prozac doesn't energize me what will?
> JaneI think that "derived from diphenhydramine" means that it (prozac) was developed from the research associated with the development of histamine blockers (since histamine is closely related to serotonin) Many antihistamines are potent SSRIs, and many SSRIs are potent antihistamines....
I believe the antihistamine Brompheniramine was first developed, which led to the development of the antihistamine chlorpheniramine, which was found to be a potent SSRI, through this, a drug called Zimelidine (the very first SSRI) was developed, and then removed from the market. Fluvoxamine (luvox) was then developed by Solvay, followed by lilly's Prozac.
poster:djmmm
thread:676911
URL: http://www.dr-bob.org/babble/20060810/msgs/677114.html