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Dr. Bob is Robert Hsiung, MD,
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Posted by laima on July 22, 2006, at 19:17:42
In reply to Re: emsam 6 mg/24 = ? oral selegiline?, posted by jealibeanz on July 22, 2006, at 18:52:22
> Was the conference in your area?
Clueless. I get the impression it was a national event, though.
I might add, after thinking about recent posts, that even these so-called expert doctors appear to be a tad confused, just like us. I wonder if that was an inspiration for such a conference to even be held.
Posted by jealibeanz on July 22, 2006, at 19:26:42
In reply to Re: emsam 6 mg/24 = ? oral selegiline? » jealibeanz, posted by laima on July 22, 2006, at 19:17:42
I was just wondering if it were something that was widely advertised. Confusion? Oh no! Not a good thing. Maybe I'll just settle for an SSRI, which I'm sure I'll end up hating b/c of side effects.
Posted by mayzee on July 22, 2006, at 21:19:20
In reply to Re: emsam 6 mg/24 = ? oral selegiline? » mayzee, posted by laima on July 22, 2006, at 18:31:03
>
> Is this practice of cutting up 6's working out for you? I'll do the same if you and others have found it to be safe and accurate...
>Seems to be working fine for me. Safe, yes. "accurate"? who knows?!
In going up to the higher dose I got a rebound on some of the side effects I'd had when starting at 6 (insomnia, GI distress).
I seem to have more orthostatic hypotension at 9mg; feel more spacey at times. I guess I should get a blood pressure monitor as I tend to have low bp anyway.
But I also seem to be starting to feel better at this dose too (knock wood) I'm in my 2nd week at 9mg, and just a few days ago started to notice an improvement. (I'm scared I'll jinx it!)Best of luck to you with it!!!
Posted by Jost on July 22, 2006, at 22:45:57
In reply to Re: emsam 6 mg/24 = ? oral selegiline? » Jost, posted by laima on July 22, 2006, at 18:37:05
Laima, this is a powerpoint demonstration given to the FDA by Somerset, which describes the tyramine challenges and the reactions on those taking parnate vs emsam.
if the link doesn't work, I always find it by searching on google for "Lawrence Blob" the MD who made the presentation for Somerset.
www.fda.gov/ohrms/dockets/ac/05/slides/2005-4186S2_03_Somerset-EMSAM.ppt
Jost
Posted by laima on July 23, 2006, at 8:53:52
In reply to Re: emsam 6 mg/24 = ? oral selegiline?, posted by jealibeanz on July 22, 2006, at 19:26:42
I doubt it was heavily advertised- if you mean the conference I recently heard about. I got the impression it was specifically targeted to certain psychiatrists, only- meaning- those who specialize in drug research. Definately not open to us in the public or to other doctors. I think the company had an interest in getting feedback from people they considered experts (?). I think it was also quite academic. My doctor, who attended, is a medical professor and specializes in drugs, drug chemistry, etc. He consults and gives feedback to the companies as they develope new drugs. I'm sure that is why he was there.
As for my pharmacists- they made it sound like the EMSAM folks are going around trying to do an education blitz for pharmacists- so very likely your pharmacists will get this chance, too. I think the company is acknowlegeing that loads of people, even pharmacists, are uttery confused.
I do think it would be nice of the company to do more education to help us regular people figure out this confusing medication, Itotally agree with that. And I think they should have sessions for ordinary or more general psychiatrists and doctors- i bet they will.
On the positive side- they appear to be acknowledging our general mass confusion, and to be on a campaign to address it. I haven't checked their website, but i wonder if they might not have a feedback form somewhere there. I can tell you when my enthusiastic doctor put me on the phone with them, they were beside themselves to hear what I had to say about EMSAM, what my opinions were, all in excruciating detail. AND they have put a questionaire in the mail, which I am expecting soon, for even more feedback. I'm not special- I bet they will listen to any of us. We just need to find the channel.
As for confusion, what i gather from reading everyone's posts and from what i heard at the doctor's office- most of it seems to revolve around what on earth the doses mean, and are certain foods ok or not on the diffrent doses.
Oh ssris- easy, sure. If they work for you-lucky you. Prozac was a miracle for me once until it utterly "pooped out" after approximately 10 years. No ssri has ever worked for me ever again. Nor has any other anti-depresswent I ever tried. Scary. Did something happen to my brain? Is it because my depression can be described as "atypical" and ssris not famous for being super helpful with that?? I know I could be headed for a similar scenario with EMSAM- but I don't know if I have much choice.
> I was just wondering if it were something that was widely advertised. Confusion? Oh no! Not a good thing. Maybe I'll just settle for an SSRI, which I'm sure I'll end up hating b/c of side effects.
Posted by laima on July 23, 2006, at 9:01:11
In reply to Re: emsam 6 mg/24 = ? oral selegiline? » laima, posted by mayzee on July 22, 2006, at 21:19:20
Oh thank you for your response, it's so hopeful and encouraging!! As for blood pressure- yes, maybe it would be worth looking in to for you, too. I'd been told a few times that the EMSAM can cause it to really dip in lots of people. When I started EMSAM, my main problem was I was l-e-t-h-a-r-g-i-c, dizzyish, all that. I'm actually on a teeny amount of ritalin (5mg 2xday) now for purpose to boost it up. Seems to be working out great. Best of luck to you, too!> >
> > Is this practice of cutting up 6's working out for you? I'll do the same if you and others have found it to be safe and accurate...
> >
>
> Seems to be working fine for me. Safe, yes. "accurate"? who knows?!
>
> In going up to the higher dose I got a rebound on some of the side effects I'd had when starting at 6 (insomnia, GI distress).
> I seem to have more orthostatic hypotension at 9mg; feel more spacey at times. I guess I should get a blood pressure monitor as I tend to have low bp anyway.
> But I also seem to be starting to feel better at this dose too (knock wood) I'm in my 2nd week at 9mg, and just a few days ago started to notice an improvement. (I'm scared I'll jinx it!)
>
> Best of luck to you with it!!!
Posted by SLS on July 23, 2006, at 9:01:59
In reply to Re: emsam 6 mg/24 = ? oral selegiline? » jealibeanz, posted by laima on July 23, 2006, at 8:53:52
> Oh ssris- easy, sure. If they work for you-lucky you. Prozac was a miracle for me once until it utterly "pooped out" after approximately 10 years.
Can you ascribe to this a particular life event or series of stressors? What about changes in hormonal biology? What about intense physical exercise? How old were you when this happened?
- Scott
Posted by jealibeanz on July 23, 2006, at 9:25:46
In reply to Re: emsam 6 mg/24 = ? oral selegiline? » jealibeanz, posted by laima on July 23, 2006, at 8:53:52
I don't actually think SSRI's would help, but maybe I could bring it up as an option, I'm afraid to though. I really don't think I'll ever be properly medicated. It seems the harder I've ever pursued, the worse treatment I got (with new docs and a psychiatrist). They seem to not take me seriously, make me feel like a horrible messed up human being who's just a little kid and isn't having the perfect fantasy life and therefore wants drugs, and then they turn me away saying I have no depression or anxiety.
My family practitioner is the only person who ever acts at all interested. That is why I'm with him right now. I'm so thankful that he's willing to give me Xanax, without making me feel like an addict. And, he did increase my dosage to .5 mg 3xdaily. That's actually going to be a little much, but maybe I won't tell him that. I fear that I need to hoard the medication, because once I move farther, or god forbid he moves, I'll never get it again.
The depression is bad though, and he doesn't know it. It's not that it's always terrrible, but it's knowing that it's recurrent (definitely seasonal and other times too) since I was 15 and willlll come back that makes it so tough to have a positive outlook. I feel weak for not be happy with my life and for complaining to my doc. I have a good family, friends, and wonderful opportunities and experiences. I should be happy, yet I'm sitting here crying as I write this.
I don't sleep right now more than 3-4 hours a night for the past few months. So that doesn't help. But I don't want to write my depression off as being caused by insomnia and anxiety. They're just comorbidities or symptoms of the depression in my opinion.
Posted by laima on July 23, 2006, at 10:24:57
In reply to Re: emsam 6 mg/24 = ? oral selegiline?, posted by Jost on July 22, 2006, at 22:45:57
Thank you.
> Laima, this is a powerpoint demonstration given to the FDA by Somerset, which describes the tyramine challenges and the reactions on those taking parnate vs emsam.
>
> if the link doesn't work, I always find it by searching on google for "Lawrence Blob" the MD who made the presentation for Somerset.
>
> www.fda.gov/ohrms/dockets/ac/05/slides/2005-4186S2_03_Somerset-EMSAM.ppt
>
> Jost
Posted by laima on July 23, 2006, at 10:34:39
In reply to Re: emsam 6 mg/24 = ? oral selegiline? » laima, posted by SLS on July 23, 2006, at 9:01:59
Good questions- no one had an easy answer, but my doctor said in fact, reports of the phenomena, known as "prozac poop-out" have started to show up in med journals.I was on it for about 10 years, great at first, and then it slid off somehow. I've never managed to get it to work again- no incrreased dose, nothing. No other ssris, either. Some brief relief from Wellbutrin, before that faded too. Now I'm doing a drastic change by going with the EMSAM, fingers crossed.
Honestly am unable to come up with any life event which could have triggered my response to flop. I've always been a vigourous excersiser. I started prozac when it first came out-I think that was 1988 89? and used until almost 2000. So- mostly during my 20's until about 30. Then zoloft one year, with tepid respponse, even to highest allowed dose, then that fizzled after less than a year. Trouble ever since.
Hormones? Unsure. I've been through a zillion blood tests, though.
> > Oh ssris- easy, sure. If they work for you-lucky you. Prozac was a miracle for me once until it utterly "pooped out" after approximately 10 years.
>
> Can you ascribe to this a particular life event or series of stressors? What about changes in hormonal biology? What about intense physical exercise? How old were you when this happened?
>
>
> - Scott
>
>
Posted by SLS on July 23, 2006, at 10:55:08
In reply to Re: emsam 6 mg/24 = ? oral selegiline? » SLS, posted by laima on July 23, 2006, at 10:34:39
Thanks for the response.
Significant changes occur in the body at age 30 and again at age 40. It is interesting that poop-out for you occured at age 30 when nothing else could account for it.
Just trying to figure things out...
Good luck with Emsam. You have the right idea using a completely different angle of attack. I hope it works for you.
- Scott
Posted by laima on July 23, 2006, at 12:10:29
In reply to Re: emsam 6 mg/24 = ? oral selegiline? » laima, posted by SLS on July 23, 2006, at 10:55:08
I thank you, too. Good points about body changes at ages 30 and 40. I do know I am absolutely too young for menopause or anything like that, (unless I am going through some unusually early pre-menopause stage?), but perhaps something else is going on. No doctor ever mention the possibility of hormonal changes as a possible reason-but that doesn't mean it's not a plausable explanation. I'll add that the real slide hit me by age 28. Dose was increased to maximum allowed, but provided no improvement. Just around 30, even the highest allowed dose was utterly ineffective. I asked, "did my brain change from long-term use of the drug?" Answer-"Possible- unlikely- but definately possible". Does this mean I'm more depressed or developed new issues? Same answer. And so on. I guess the existence of the "poop out" phenomena is debated by "the experts", and doesn't necessarily happen to everyone. But even those who believe it don't seem to be able to explain it.
If you google, you'll seee there are lots of med abstracts and other writings about this troubeling topic. I saw one which suggested ssris might plausabley deplete dopamine while they are busy boosting seratonin. (??) I hope that's not true.
I am concerned that I was amongst the first people to get prozac- got it the very month it was approved and hailed as a miracle. No one knew the long term effects, if any, at the time- but I was so unbelievabley grateful for the dramatic, rapid relief that I didn't care. I was 18, I think. Before that, I went through the whole gamut of trycyclics (or however that's spelled), and they all caused me horrible side effects, like sleeping 20 hours per day, groggy beyond belief, fast weight gain, migrainish headache, nausea, general "oddness", and I'm told, strange facial expression--and little, if any, relief. Prozac literally gave me my life back-for awhile. Truely, what a dramatic and rapid miracle it was. Can't possibly exaggerate.
Meanwhile, I am waiting for my new, higher dose EMSAM to arrive at the pharmacy, not in stock as I am their first customer to ever get it, but I've got my hopes up.
> Thanks for the response.
>
> Significant changes occur in the body at age 30 and again at age 40. It is interesting that poop-out for you occured at age 30 when nothing else could account for it.
>
> Just trying to figure things out...
>
> Good luck with Emsam. You have the right idea using a completely different angle of attack. I hope it works for you.
>
>
> - Scott
Posted by Phillipa on July 23, 2006, at 20:45:56
In reply to Re: more on prozac poop-out phenom » SLS, posted by laima on July 23, 2006, at 12:10:29
You know doctors dismiss hormones too quickly. And did you know that peri-menopause lasts l0-l5yrs? I only just learned this. And this the time period when all my problems began with anxiety and depression getting out of hand. I asked to have them checked when my FSH reached 50 as that means you're starting menopause but the docs wouldn't do it. I hear now that the OB-GYN's are doing hormone testing. I'm due in a few months for my annual so I will be asking for hormone tests even though I've gone through Menopause. You do still produce some and may need hormones. Years ago women didn't live til menopause. Love Phillipa
Posted by laima on July 23, 2006, at 21:14:10
In reply to Re: more on prozac poop-out phenom » laima, posted by Phillipa on July 23, 2006, at 20:45:56
Very interesting points and info. Thank you, Phillipa.
> You know doctors dismiss hormones too quickly. And did you know that peri-menopause lasts l0-l5yrs? I only just learned this. And this the time period when all my problems began with anxiety and depression getting out of hand. I asked to have them checked when my FSH reached 50 as that means you're starting menopause but the docs wouldn't do it. I hear now that the OB-GYN's are doing hormone testing. I'm due in a few months for my annual so I will be asking for hormone tests even though I've gone through Menopause. You do still produce some and may need hormones. Years ago women didn't live til menopause. Love Phillipa
Posted by jealibeanz on July 24, 2006, at 20:24:18
In reply to Re: emsam 6 mg/24 = ? oral selegiline?, posted by jealibeanz on July 23, 2006, at 9:25:46
He does think primary concern is social anxiety. Honestly, I feel it's much much stronger general constant nonstop anxiety than social anxiety, but not aware that depression is current, or organic in the past. He thought I was taking Effexor by his PA just because of drug induced crying spells (Adderall + Klonopin). Anyway, MAOI's are known as the "Gold Standard" for social anxiety. I know that although he doesn't have a problem with me taking Xanax for anxiety right now, he sorta mentioned that hopefully I'd be able to make it on my own without it. I think that's because we both know my future career may be in jeopardy if I'm taking daily Xanax. Maybe he'll come up with the idea of an MAOI, which I believe is looked upon more favorable (in terms of being drug-seeking, drug-dependent) by employers.
Posted by mayzee on July 24, 2006, at 22:34:10
In reply to Re: emsam 6 mg/24 = ? oral selegiline?, posted by jealibeanz on July 24, 2006, at 20:24:18
> Maybe he'll come up with the idea of an MAOI, which I believe is looked upon more favorable (in terms of being drug-seeking, drug-dependent) by employers.
>Hi jealibeanz,
My ongoing question with your posts is -- why won't you just ask your GP for Emsam? The way you describe him is that he's very caring and understanding. And you seem so knowledgable about yourself and about meds. I just want to say to you Sweetie, please just ask him. I feel bad that you seem so anxious about it. Sounds from your posts like he would be very open to hearing what you have to suggest. No? I don't mean to downplay your anxiety; just hate to hear you worry so much about it. So just wanted to be encouraging to give it a try to ask him.
Wishing you the best!!!
mayzee
Posted by jealibeanz on July 25, 2006, at 11:22:55
In reply to Re: emsam 6 mg/24 = ? oral selegiline? » jealibeanz, posted by mayzee on July 24, 2006, at 22:34:10
Yes, I am doing quite a bit of worrying about the matter. Obviously asking him directly would be the most sensible thing to do. I just feel silly/pretentious coming home after my first semester and acting like I now know everything about medicine, as ifI think I'm ready to start writing prescriptions myself.
Posted by laima on July 25, 2006, at 12:15:51
In reply to Re: emsam 6 mg/24 = ? oral selegiline?, posted by jealibeanz on July 25, 2006, at 11:22:55
Perhaps going in and saying "I want EMSAM, now, because I read all about it and I'm quite positive, based on my own research, it's the medication for me" could sound pretentious.But-
What if you phrased it something like, "I heard a lot of interesting things in the news about a new medication, EMSAM, recently, and was wondering what you think about it and if it might me helpful for me"?
I wouldn't think that could sound at all pretentious or as if you felt ready to write prescriptions yourself.
Good luck.
Sincerely,
Laima
> Yes, I am doing quite a bit of worrying about the matter. Obviously asking him directly would be the most sensible thing to do. I just feel silly/pretentious coming home after my first semester and acting like I now know everything about medicine, as ifI think I'm ready to start writing prescriptions myself.
Posted by mayzee on July 25, 2006, at 13:29:11
In reply to Re: emsam 6 mg/24 = ? oral selegiline? » jealibeanz, posted by laima on July 25, 2006, at 12:15:51
>
> What if you phrased it something like, "I heard a lot of interesting things in the news about a new medication, EMSAM, recently, and was wondering what you think about it and if it might me helpful for me"?
>
> I wouldn't think that could sound at all pretentious or as if you felt ready to write prescriptions yourself.
>
>I agree, jealibeanz. I don't have any medical training but I still talk to my pdoc about what I've read. That's how I came to be on Emsam. I'd read about the FDA approval and asked my pdoc about it. I was his first patient to try it.
I think the more upfront & honest you can be with your doc (e.g., telling him about your depression) the better chance of his helping you.
Good luck! and please let us know how it goes!
mayzee
Posted by jealibeanz on July 25, 2006, at 13:40:52
In reply to Re: emsam 6 mg/24 = ? oral selegiline? » jealibeanz, posted by laima on July 25, 2006, at 12:15:51
I know I wish it were that easy for me to ask. It's not even a med recheck, it's a physical. So I'd have to go out of my way to get his attention. Otherwise, he may not even ask about my current meds, which aren't really going that well.
Posted by jealibeanz on July 25, 2006, at 16:56:06
In reply to Re: emsam 6 mg/24 = ? oral selegiline?, posted by mayzee on July 25, 2006, at 13:29:11
Yeah, I know it's best to be honest, since he may be able to help me. I'm just at a loss for words when breeching the subject. It's the times when you need help that's it tough to ask and talk about. Other times I have no problem talking about myself or other matters with him and anyone else.
Posted by mayzee on July 26, 2006, at 8:58:59
In reply to Re: emsam 6 mg/24 = ? oral selegiline?, posted by jealibeanz on July 25, 2006, at 16:56:06
> Yeah, I know it's best to be honest, since he may be able to help me. I'm just at a loss for words when breeching the subject.
>Here's an idea: as an training PA, think about what it will be like for you when you have a patient come in for help. How much you really want to help them, but you're also relying on them to accurately describe what's going on with them. Can you put yourself in your GP's shoes that way?
>It's the times when you need help that's it tough to ask and talk about.
>Amen! I know just how you feel. I often think that if I were well enough to get the help I need, then I wouldn't need it!
Posted by jealibeanz on July 26, 2006, at 11:36:00
In reply to Re: emsam 6 mg/24 = ? oral selegiline?, posted by mayzee on July 26, 2006, at 8:58:59
But you are getting medical intervention, right? You mention your pdoc.
Any ideas as to how to begin talking about depression? I know so many people see him and any family practitioner for this matter (I actually am aware that he has tonsss of patients on Zoloft. I worked as a pharm tech in town for a while.)
Still, I just can't imagine what most people say. And I know I'm a more complicated case b/c I don't react well to their favorite SSRI's.
Posted by jealibeanz on July 27, 2006, at 11:41:28
In reply to Re: emsam 6 mg/24 = ? oral selegiline?, posted by mayzee on July 26, 2006, at 8:58:59
True... makes me feel a little more confident in getting my own help when thinking about how I'd want to help others. I'd like to actually see how most people approach their doctors, since I've never been present for an initial complaint in patients, just check ups when things were going OK. Ha, I'm being treated for anxiety, insomnia, and ADHD right now. It's not a surprise to add depression to the list! Not like he'd be surprised.
Posted by jealibeanz on July 28, 2006, at 8:21:38
In reply to Re: emsam 6 mg/24 = ? oral selegiline?, posted by jealibeanz on July 27, 2006, at 11:41:28
Also, does anyone know of a good sleep aid beside Lunesta? I hated Ambien, too sedating, plus I was sleep walking and having nightmares. Lunesta was good because I didn't "feel" it, but it has stopped working.
This is the end of the thread.
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