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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 13 of 13. This is the beginning of the thread.
Posted by capricorn on July 10, 2006, at 15:36:46
http://www.newscientist.com/article/dn9516-abortion-drug-could-rapidly-treat-depression.html
Posted by Phillipa on July 10, 2006, at 16:21:39
In reply to Abortion drug could rapidly treat depression, posted by capricorn on July 10, 2006, at 15:36:46
Didn't Scott SLS try this? Love Phillipa
Posted by tgo on July 10, 2006, at 17:00:48
In reply to Abortion drug could rapidly treat depression, posted by capricorn on July 10, 2006, at 15:36:46
> http://www.newscientist.com/article/dn9516-abortion-drug-could-rapidly-treat-depression.html
Cool! Thanks for posting that. The story about scientists finding a faulty gene that is present in both depression and bipolar was interesting and that they are already working on developing a medicine to target it is great news.
Posted by bipolarspectrum on July 10, 2006, at 18:03:15
In reply to Abortion drug could rapidly treat depression, posted by capricorn on July 10, 2006, at 15:36:46
> http://www.newscientist.com/article/dn9516-abortion-drug-could-rapidly-treat-depression.html
Hi,
Yeah, this has been around for a few years and the FDA is actually fast tracking it for psychotic depression... im not sure if RU will be effective for all types, but the research shows it has benefits for psychotic and bipolar depression... if ur an american, u could potenitally get ur hands on a sample of this, depending on ur state i understand...
bps
Posted by linkadge on July 10, 2006, at 19:47:46
In reply to Re: Abortion drug could rapidly treat depression, posted by bipolarspectrum on July 10, 2006, at 18:03:15
Fasttrack...heh.
I'd hate to see the slow track. :)
Linkadge
Posted by SLS on July 10, 2006, at 21:57:12
In reply to Abortion drug could rapidly treat depression, posted by capricorn on July 10, 2006, at 15:36:46
I tried RU-486, now known more universally as mifepristone (Mifeprex, Corlux). In addition to blocking progesterone receptors, it also blocks cortisol receptors. The idea is that you take the drug every day (600mg) for a week and then discontinue it. It is thought to reset the HPA system in the body and allows one to remain free of depression for an extended period of time thereafter. It didn't work for me.
Compassionate Use Project
Contact Information:Feminist Majority Foundation
703-522-2214
www.feminist.org
- Scott
Posted by med_empowered on July 11, 2006, at 1:54:20
In reply to Re: Abortion drug could rapidly treat depression, posted by SLS on July 10, 2006, at 21:57:12
Since this drug has been around for a while in both the US and internationally, does that mean docs will just use this form off-label? Or is a more expen$ive, "improved" product in development?
Posted by SLS on July 11, 2006, at 6:33:40
In reply to RU-486 for depression..., posted by med_empowered on July 11, 2006, at 1:54:20
> Since this drug has been around for a while in both the US and internationally, does that mean docs will just use this form off-label? Or is a more expen$ive, "improved" product in development?
I am not aware of any other cortisol receptor antagonists in the pipeline. I imagine there is some interest, though.
Mifepristone is not available by prescription. When used for medical abortion, it is available only directly to physicians who meet certain criteria set forth by the FDA. Patients must sign a patient agreement and agree to return for subsequent visits. When used for depression, a IND must be submitted to the FDA and a petition made to the Feminist Majority Foundation for a supply of the drug under a compassionate use protocol. Of course, the drug is also available in investigative studies.
- Scott
Posted by linkadge on July 11, 2006, at 16:30:55
In reply to Re: RU-486 for depression..., posted by SLS on July 11, 2006, at 6:33:40
RU-486 is not going to work for everbody based on the fact that not everybody's depression is associated with high levels of cortisol.
Linkadge
Posted by ravenstorm on July 13, 2006, at 15:42:44
In reply to Re: Abortion drug could rapidly treat depression, posted by SLS on July 10, 2006, at 21:57:12
Scott, what were the side effects of the treatment?
I am particualarly interested in this because my hormone testing revealed I have progesterone levels twice the normal range. I should get my cortisol levels checked.
Posted by SLS on July 13, 2006, at 16:39:47
In reply to Re: Abortion drug could rapidly treat depression, posted by ravenstorm on July 13, 2006, at 15:42:44
> Scott, what were the side effects of the treatment?
I really didn't have any. However, I don't have a uterus. I don't know if your condition would have any impact upon the side effects mifepristone produces. Generally, there aren't any in healthy females who aren't pregnant.
I actually began to respond to it somewhat after the first few days. However, this improvement disappeared, and I felt washed-out by the end of the week. It is possible that my adrenals began producing too much cortisol and were exhausted.
> I am particualarly interested in this because my hormone testing revealed I have progesterone levels twice the normal range. I should get my cortisol levels checked.
What options do you have to treat that?
- Scott
Posted by laima on July 20, 2006, at 11:05:24
In reply to Re: RU-486 for depression..., posted by linkadge on July 11, 2006, at 16:30:55
Good point....but I wish I could get myself in somewhere to try it, because I think stress/high cortisol is a problem for me. I've asked around and it seems near impossible, and very politically muddled by the anti-abortion community who seem to want the drug and trials banned altogether.If anyone knows of any clinic actually offering this-not a placebo- can they say?
> RU-486 is not going to work for everbody based on the fact that not everybody's depression is associated with high levels of cortisol.
>
> Linkadge
>
>
Posted by anhedonic on July 20, 2006, at 20:52:41
In reply to Re: RU-486 for depression..., posted by laima on July 20, 2006, at 11:05:24
Please babble mail me for information if you like.
> Good point....but I wish I could get myself in somewhere to try it, because I think stress/high cortisol is a problem for me. I've asked around and it seems near impossible, and very politically muddled by the anti-abortion community who seem to want the drug and trials banned altogether.
>
> If anyone knows of any clinic actually offering this-not a placebo- can they say?
>
> > RU-486 is not going to work for everbody based on the fact that not everybody's depression is associated with high levels of cortisol.
> >
> > Linkadge
> >
> >
>
>
This is the end of the thread.
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