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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by Maximus on May 15, 2006, at 12:34:46
"An open-label series using loratadine for the treatment of sexual dysfunction associated with selective serotonin reuptake inhibitors."
**************************************
Hi,
Yes that's the good old Claritin, an antihistaminic. I tried it and it works very well. 20 mgs were needed to relieve the sexual side effects from Effexor 150 mgs. Loratadine targets all departments except the libido.
May be a partial solution in waiting for a clean 5HT2A antagonist?
Posted by SLS on May 15, 2006, at 13:12:43
In reply to Loratadine for SSRI's sexual dysfunction, posted by Maximus on May 15, 2006, at 12:34:46
> "http://miniurl.org/lvp"
>
> "An open-label series using loratadine for the treatment of sexual dysfunction associated with selective serotonin reuptake inhibitors."
>
> **************************************
>
> Hi,
>
> Yes that's the good old Claritin, an antihistaminic. I tried it and it works very well. 20 mgs were needed to relieve the sexual side effects from Effexor 150 mgs. Loratadine targets all departments except the libido.
>
> May be a partial solution in waiting for a clean 5HT2A antagonist?They already exist. The trick is to convince a drug company that there will be a profit in marketing such a drug. Ritanserin is an example of a drug that is a selective antagonist for 5-HT2a/c receptors. It would probably make a good adjunct to SRI drugs to increase efficacy and reduce side effects. It is a good drug without a good reason to develop beyond its use in the laboratory.
- Scott
Posted by Declan on May 15, 2006, at 15:11:02
In reply to Loratadine for SSRI's sexual dysfunction, posted by Maximus on May 15, 2006, at 12:34:46
Would loratadine work for Nardil induced sexual dysfunction? How does it compare with cyproheptadine? Etc.
Declan
Posted by Maximus on May 15, 2006, at 15:46:11
In reply to Loratadine for Nardil sexual dysfunction????, posted by Declan on May 15, 2006, at 15:11:02
> Would loratadine work for Nardil induced sexual dysfunction? How does it compare with cyproheptadine? Etc.
> DeclanI think it is contraindicated to take Periactin and Nardil together.
I never used it myself, but i would think that Periactin is more effective. But it is also a "dirtier" drug than Loratadine with a lot more side effects too...
Posted by gardenergirl on May 15, 2006, at 15:52:14
In reply to Re: Loratadine for Nardil sexual dysfunction???? » Declan, posted by Maximus on May 15, 2006, at 15:46:11
I used to take Loratadine every day while also taking Nardil. I stopped awhile ago due to dry mouth, and I wasn't really suffering from alllergies at the time.
Anyway, I still had some anorgasmia while taking loratadine. It always improved after a few months, but still...loratadine didn't prevent it.
For what it's worth...
gg
Posted by rjlockhart on May 15, 2006, at 20:04:51
In reply to Loratadine for SSRI's sexual dysfunction, posted by Maximus on May 15, 2006, at 12:34:46
mmmm.... you know i dont know really what antihistimines have on serotonin or really even any of the nueroreceptor sites.
Good to here it working
Matt
Posted by Caedmon on May 15, 2006, at 22:41:16
In reply to Re: Loratadine for SSRI's sexual dysfunction, posted by rjlockhart on May 15, 2006, at 20:04:51
I don't believe cyproheptadine is contraindicated with MAOIs. In fact, I believe it's very often used in the management of serotonin syndrome secondary to MAOIs and other serotonergic antidepressants.
I'm a little surprised to hear of loratadine for sexual dysfunction. I understood that the benefit of this drug was that it was an antihistamine, but that it would be *less* apt to cross the blood-brain barrier vs. first-generation antihistamines? Seems a convoluted way of achieving such a goal.
- Chris
Posted by Larry Hoover on May 15, 2006, at 23:09:36
In reply to Re: Loratadine for SSRI's sexual dysfunction, posted by Caedmon on May 15, 2006, at 22:41:16
> I don't believe cyproheptadine is contraindicated with MAOIs. In fact, I believe it's very often used in the management of serotonin syndrome secondary to MAOIs and other serotonergic antidepressants.
That's good news.
> I'm a little surprised to hear of loratadine for sexual dysfunction. I understood that the benefit of this drug was that it was an antihistamine, but that it would be *less* apt to cross the blood-brain barrier vs. first-generation antihistamines? Seems a convoluted way of achieving such a goal.
>
> - ChrisThe theory, as I understand it, is that loratadine changes the effects in the periphery, rather than centrally. It influences specific serotonin receptors that are in the genitals, protecting them from unwanted effects caused by peripheral SSRI activity.
Lar
Posted by ed_uk on May 16, 2006, at 13:59:29
In reply to Re: Loratadine for SSRI's sexual dysfunction » Caedmon, posted by Larry Hoover on May 15, 2006, at 23:09:36
Hi Lar
I didn't think loratadine was active at serotonin receptors?
Ed
Posted by Larry Hoover on May 16, 2006, at 16:34:20
In reply to Re: Loratadine for SSRI's sexual dysfunction » Larry Hoover, posted by ed_uk on May 16, 2006, at 13:59:29
> Hi Lar
>
> I didn't think loratadine was active at serotonin receptors?
>
> EdMy language was somewhat ambiguous, I guess. Somehow, the loratadine effect reaches serotonergic receptors in the periphery, but I don't know the mechanism. Primary effect, secondary effect, I have no idea.
Lar
Posted by djmmm on May 17, 2006, at 7:30:31
In reply to Re: Loratadine for SSRI's sexual dysfunction » ed_uk, posted by Larry Hoover on May 16, 2006, at 16:34:20
> > Hi Lar
> >
> > I didn't think loratadine was active at serotonin receptors?
> >
> > Ed
>
> My language was somewhat ambiguous, I guess. Somehow, the loratadine effect reaches serotonergic receptors in the periphery, but I don't know the mechanism. Primary effect, secondary effect, I have no idea.
>
> Lar
>
>I think you'll find that most antihistamines (first generation, and newer agents) have some serotonin activity... like SSRIs, histamine antagonists aren't necessarily that "selective" to histamine.
This is the end of the thread.
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