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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by Don_Bristol on May 7, 2006, at 6:16:41
I take Parnate and as we know Parnate is energising.
ISTR that the data sheet says it takes something like an hour or so for Parnate to reach max concentration in the body.
I don't like to take Parnate after about 5pm to allow better sleep at night. However I would like to be able to time my doses of Parnate to give me a boost in the day when I need it.
It must be much better to do this than to take the 3-spoon Nescafe I am sadly using more and more.
QUESTION: Does anyone notice a boost or lift from the time of taking Parnate to a few hours afterwards?
I am not sure that I do but then again I find the energising effect can be strong but subtle and hard to notice in oneself.
Posted by willyee on May 7, 2006, at 12:08:17
In reply to Timing Parnate to work as a pep pill?, posted by Don_Bristol on May 7, 2006, at 6:16:41
Dosage,tolerance,other meds etc might play a role,but i can simplify parnate to one degree,usualy it can cause fatigue in the early day,especialy at around 3 pm......however for some reason at late night around 11-12 pm its not so much a JOLT but its as if the drug becomes active and insomnia sets in.
Im not a chemisct so i cant say this for sure,buut perhaps its possable that the active metablites which are said to be some what similiar to stimulants are then becomming active at night as the drug is leaving your body,has anyone tried dosing a small parnate dose at a late time of the night to see if opposite results happen,not suggesting it at all,just asking.
Parnate for me seems to have an accumative effect that builds in a matter of days and changes the drugs value from energizing to very sedating,this is why i find myself raising the dose then lowering it again,if it stays at a high dose i get a day or two of relieaf,then lots of fatique and loss of effectivness....which i then turn to a lower dose for a while and come back to a higher dose.
If i stay at a lower dose i dont get the relieaf i need.
Its for me a very inconsisent drug,i look forward to talking to this new doc on a plan of getting off it,im ready to move on from parnate have been
Posted by tygereyes on May 7, 2006, at 14:44:41
In reply to Re: Timing Parnate to work as a pep pill?, posted by willyee on May 7, 2006, at 12:08:17
willyee, what are you thinking for your next med?
> Dosage,tolerance,other meds etc might play a role,but i can simplify parnate to one degree,usualy it can cause fatigue in the early day,especialy at around 3 pm......however for some reason at late night around 11-12 pm its not so much a JOLT but its as if the drug becomes active and insomnia sets in.
>
> Im not a chemisct so i cant say this for sure,buut perhaps its possable that the active metablites which are said to be some what similiar to stimulants are then becomming active at night as the drug is leaving your body,has anyone tried dosing a small parnate dose at a late time of the night to see if opposite results happen,not suggesting it at all,just asking.
>
>
> Parnate for me seems to have an accumative effect that builds in a matter of days and changes the drugs value from energizing to very sedating,this is why i find myself raising the dose then lowering it again,if it stays at a high dose i get a day or two of relieaf,then lots of fatique and loss of effectivness....which i then turn to a lower dose for a while and come back to a higher dose.
>
>
> If i stay at a lower dose i dont get the relieaf i need.
>
>
> Its for me a very inconsisent drug,i look forward to talking to this new doc on a plan of getting off it,im ready to move on from parnate have been
Posted by willyee on May 7, 2006, at 17:45:24
In reply to Re: Timing Parnate to work as a pep pill?, posted by tygereyes on May 7, 2006, at 14:44:41
My doc left town to pursue her retirment,choosing a new one was hard,i wanted a low key office,that was close by,and would keep me on a maoi.
I found the first two,then i spoke to the doc personaly on the phone and was assured before any changed are made,at the least she will not refuse my curremtn protocol of parnate/klonopin,she has agreed.
So until i see her and see this is the case and im at a certain ease,i havent thought too much,i look around and dont see anything at all!!
The patch im determining through reading is NOT an option,.....one thing i have thought about is to leave parnate where it is since i see no other viable option.,and PERHAPS use small doses of modfanil with KLONOPIN so i can get more out of the klonopin without fear of wrosening the depression.
Adding a small stimulant sepertate to just klonopin augmenintg seems to be the only strategy left,i have augmented parnate to death and dont believe there are even any drugs left to try.Geodon/or topamax would be possably options but again im so tired of failed parnate augment attempts i just want to go a different route.
Do you have a plan of action,or do you just predict to hang on to using parnate alone for a while?
Posted by tygereyes on May 7, 2006, at 22:05:13
In reply to Re: Timing Parnate to work as a pep pill?, posted by willyee on May 7, 2006, at 17:45:24
> My doc left town to pursue her retirment,choosing a new one was hard,i wanted a low key office,that was close by,and would keep me on a maoi.
>
> I found the first two,then i spoke to the doc personaly on the phone and was assured before any changed are made,at the least she will not refuse my curremtn protocol of parnate/klonopin,she has agreed.
>
>
> So until i see her and see this is the case and im at a certain ease,i havent thought too much,i look around and dont see anything at all!!
>
>
> The patch im determining through reading is NOT an option,.....one thing i have thought about is to leave parnate where it is since i see no other viable option.,and PERHAPS use small doses of modfanil with KLONOPIN so i can get more out of the klonopin without fear of wrosening the depression.
>
>
> Adding a small stimulant sepertate to just klonopin augmenintg seems to be the only strategy left,i have augmented parnate to death and dont believe there are even any drugs left to try.Geodon/or topamax would be possably options but again im so tired of failed parnate augment attempts i just want to go a different route.
>
>
> Do you have a plan of action,or do you just predict to hang on to using parnate alone for a while?I am on EMSAM ... not Parnate.
Posted by willyee on May 7, 2006, at 22:51:11
In reply to Re: Timing Parnate to work as a pep pill?, posted by tygereyes on May 7, 2006, at 22:05:13
But u are planning on going back right...or am i addressing the wrong person lol.I meant if it is you,then do you plan to just go back on parnate alone?
Posted by Don_Bristol on May 8, 2006, at 8:16:32
In reply to Re: Timing Parnate to work as a pep pill?, posted by willyee on May 7, 2006, at 12:08:17
> Dosage,tolerance,other meds etc might play a role, but i
> can simplify parnate to one degree,usualy it can cause
> fatigue in the early day,especialy at around 3 pm......
> however for some reason at late night around 11-12 pm
> its not so much a JOLT but its as if the drug becomes
> active and insomnia sets in.
Now that is very similar as to how I too experience Parnate. If I take a late dose then as the evening becomes night and as the night becomes the early morning, I just don't feel sleepy.
> Im not a chemisct so i cant say this for sure,buut
> perhaps its possable that the active metablites which
> are said to be some what similiar to stimulants are
> then becomming active at night as the drug is leaving
> your body,has anyone tried dosing a small parnate dose
> at a late time of the night to see if opposite results
> happen,not suggesting it at all,just asking.
I don't really know what you mean about Parnate becomeing active as the metabolites LEAVE the body. Do you mean that the pathways for absorption are in those tissues in the body which are encountered by a med as it is excreted?>
> Parnate for me seems to have an accumative effect that
> builds in a matter of days and changes the drugs value
> from energizing to very sedatingWhat you are telling me about your experience of Parnate suggests that you are getting energised but that your body then feels worn out and fatigued.
Interestingly I do not experience this exhaustion as much I expected. It is weird but if I am up all night (from a very late dose of Parnate) then I do not feel tired or sleepy until the evening the following day. I am a 6 to 7 hour a night man but a recent crisis meant that I was survining on 2 hours a night averaged over 11 days.
I can't really account for this but it seems as if you are doing something similar (the number of hours may be very different in your own case) but that you are pushing your body beyond its limit and not giving it the sleep it absolutely needs. In other words, maybe your dose of Parnate is too high for you?
Don
Posted by tygereyes on May 8, 2006, at 17:45:56
In reply to Re: Timing Parnate to work as a pep pill?, posted by willyee on May 7, 2006, at 22:51:11
> But u are planning on going back right...or am i addressing the wrong person lol.I meant if it is you,then do you plan to just go back on parnate alone?
Giving EMSAM a try first ... but if I do have to resume Parnate, I will use it as monotherapy (w/ Ambien to sleep - like before)
This is the end of the thread.
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