Psycho-Babble Medication Thread 639368

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Does nicotine inhibit MAO at high doses

Posted by rjlockhart on May 2, 2006, at 18:07:10

Ok,

Well let me get started.

I've seen alot people who smoke (not sterotyping) laugh, and be active. Well maybe because of the nicotine boost at first.

Ok, one time i was having a dissociative attack, i smoked one after the other, yes i cant belive it, but after it. I seemed in a better mood, not after the ciggarettes, just after. Im wondering if it inhibits the MAO-B, at high doses. I never smoke like that again. I dont like ciggarettes, but sometimes when im just really out of sort.. i have ADD but it doesnt help much.

Does anyone know

 

Re: Does nicotine inhibit MAO at high doses

Posted by linkadge on May 2, 2006, at 18:36:11

In reply to Does nicotine inhibit MAO at high doses, posted by rjlockhart on May 2, 2006, at 18:07:10

Its not nicotine itself, but it is certain compounds in tobacco called beta carbolines do inhibit both MAO-A and MAO-B

Beta carbolines are also in coffee, tea, and chocolate.

Linakdge

 

Re: Does nicotine inhibit MAO at high doses ยป linkadge

Posted by Crazy Horse on May 2, 2006, at 18:59:54

In reply to Re: Does nicotine inhibit MAO at high doses, posted by linkadge on May 2, 2006, at 18:36:11

> Its not nicotine itself, but it is certain compounds in tobacco called beta carbolines do inhibit both MAO-A and MAO-B
>
> Beta carbolines are also in coffee, tea, and chocolate.
>
> Linakdge

Are they in caffiene in general, like colas, etc?

Monte

 

Re: Does nicotine inhibit MAO at high doses

Posted by willyee on May 2, 2006, at 20:26:56

In reply to Re: Does nicotine inhibit MAO at high doses, posted by linkadge on May 2, 2006, at 18:36:11

Hey do u know to what degree,as in percentage wise compared to a standerd maoi drug?

Cigarettes agigtate the living hell out of me,when i smoked less parnate gave me les trouble,perhaps parnate is like welbutrin and smoking can make u nausa on it.

 

Re: Does nicotine inhibit MAO at high doses

Posted by linkadge on May 2, 2006, at 20:38:41

In reply to Re: Does nicotine inhibit MAO at high doses, posted by willyee on May 2, 2006, at 20:26:56

I don't think that beta carbolines are in cola's. Its independant of the caffiene. You can get MAO inhibition from decaff coffee.

I know that some studies show that heavy smokers have about 50% less MAO-A and MAO-B. So it could definately interact with a MAO inhibitor.

The beta carbolines are reversable inhibitors of MAO, meaning that their effects only last about 6-8 hours, and after that normal MAO activity resumes.

So to achieve steady MAO inhibition from beta carbolines, you probably have to smoke or whatever a few times per day.

Linkadge


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