Psycho-Babble Medication Thread 588199

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Valdoxan (agomelatine) - Any news?

Posted by Rayray on December 11, 2005, at 19:29:15

Has anyone had any experiences with Valdoxan in clinical trials? Are there any clinical trials going on in the US? Looking at some of the antidepressants in the pipeline, this one seems very promising.

I remember being very eager for Cymbalta when that was on the horizon, but unfortunately for me, it only raised my BP and made me irritable. So it was back to Zoloft 150mg + Wellbutrin 300mg/per day. It works OK for me, but not great. Which is why I keep looking...

So, all of you warm, knowledgeable, caring Psychobabblers, any thoughts?

Take care,

Ray

 

Re: Valdoxan (agomelatine) - Any news? » Rayray

Posted by Phillipa on December 11, 2005, at 20:04:10

In reply to Valdoxan (agomelatine) - Any news?, posted by Rayray on December 11, 2005, at 19:29:15

Well first of all what is it? Fondly, Phillipa

 

Re: Valdoxan (agomelatine) - Any news?

Posted by Rayray on December 11, 2005, at 21:31:24

In reply to Re: Valdoxan (agomelatine) - Any news? » Rayray, posted by Phillipa on December 11, 2005, at 20:04:10

Valdoxan is a melatonergic antidepressant shown in some studies to have the efficacy of Effexor, but with a much better side effect profile. It's in Phase III trials in Europe right now. Here's one link you might find useful:

http://www.medicalnewstoday.com/medicalnews.php?newsid=22334

Ray

 

Re: Valdoxan (agomelatine) - Any news? » Rayray

Posted by Phillipa on December 11, 2005, at 21:55:53

In reply to Re: Valdoxan (agomelatine) - Any news?, posted by Rayray on December 11, 2005, at 21:31:24

Sounds like the magic pill. But a lot of these meds never make it to the states. Do you think this one will? Are they doing anything with it yet here? Fondly, Phillipa

 

Re: Valdoxan (agomelatine) - Any news? » Rayray

Posted by lunesta on December 12, 2005, at 6:06:29

In reply to Re: Valdoxan (agomelatine) - Any news?, posted by Rayray on December 11, 2005, at 21:31:24

My question is how is this different than the currently available sleep medicine Rozerem, also a high affinity MT1 and MT2 melatonergic agonist.

They have the exact same profile. Different drugs, different purpose, nearly the same exact binding sites.

I would bet Rozerem can and would work as an antidepressant as well. I am asking my doc for it for sleep.

 

Re: Valdoxan (agomelatine) - Any news? » lunesta

Posted by SLS on December 12, 2005, at 7:02:58

In reply to Re: Valdoxan (agomelatine) - Any news? » Rayray, posted by lunesta on December 12, 2005, at 6:06:29

Hi.

> My question is how is this different than the currently available sleep medicine Rozerem, also a high affinity MT1 and MT2 melatonergic agonist.
>
> They have the exact same profile. Different drugs, different purpose, nearly the same exact binding sites.

Agomelatine does other things as well. For instance, it is a competitive antagonist at the 5-HT2C receptor. Small differences in drugs can have profound effects.

> I would bet Rozerem can and would work as an antidepressant as well. I am asking my doc for it for sleep.

I wish you luck. Please post your experiences with Rozerem. If it works for you as an antidepressant, I would like to put it on my list of things to try. Unfortunately, taking melatonin seems to make me feel worse.


- Scott


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