Shown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by Rayray on December 11, 2005, at 19:29:15
Has anyone had any experiences with Valdoxan in clinical trials? Are there any clinical trials going on in the US? Looking at some of the antidepressants in the pipeline, this one seems very promising.
I remember being very eager for Cymbalta when that was on the horizon, but unfortunately for me, it only raised my BP and made me irritable. So it was back to Zoloft 150mg + Wellbutrin 300mg/per day. It works OK for me, but not great. Which is why I keep looking...
So, all of you warm, knowledgeable, caring Psychobabblers, any thoughts?
Take care,
Ray
Posted by Phillipa on December 11, 2005, at 20:04:10
In reply to Valdoxan (agomelatine) - Any news?, posted by Rayray on December 11, 2005, at 19:29:15
Well first of all what is it? Fondly, Phillipa
Posted by Rayray on December 11, 2005, at 21:31:24
In reply to Re: Valdoxan (agomelatine) - Any news? » Rayray, posted by Phillipa on December 11, 2005, at 20:04:10
Valdoxan is a melatonergic antidepressant shown in some studies to have the efficacy of Effexor, but with a much better side effect profile. It's in Phase III trials in Europe right now. Here's one link you might find useful:
http://www.medicalnewstoday.com/medicalnews.php?newsid=22334
Ray
Posted by Phillipa on December 11, 2005, at 21:55:53
In reply to Re: Valdoxan (agomelatine) - Any news?, posted by Rayray on December 11, 2005, at 21:31:24
Sounds like the magic pill. But a lot of these meds never make it to the states. Do you think this one will? Are they doing anything with it yet here? Fondly, Phillipa
Posted by lunesta on December 12, 2005, at 6:06:29
In reply to Re: Valdoxan (agomelatine) - Any news?, posted by Rayray on December 11, 2005, at 21:31:24
My question is how is this different than the currently available sleep medicine Rozerem, also a high affinity MT1 and MT2 melatonergic agonist.
They have the exact same profile. Different drugs, different purpose, nearly the same exact binding sites.
I would bet Rozerem can and would work as an antidepressant as well. I am asking my doc for it for sleep.
Posted by SLS on December 12, 2005, at 7:02:58
In reply to Re: Valdoxan (agomelatine) - Any news? » Rayray, posted by lunesta on December 12, 2005, at 6:06:29
Hi.
> My question is how is this different than the currently available sleep medicine Rozerem, also a high affinity MT1 and MT2 melatonergic agonist.
>
> They have the exact same profile. Different drugs, different purpose, nearly the same exact binding sites.Agomelatine does other things as well. For instance, it is a competitive antagonist at the 5-HT2C receptor. Small differences in drugs can have profound effects.
> I would bet Rozerem can and would work as an antidepressant as well. I am asking my doc for it for sleep.I wish you luck. Please post your experiences with Rozerem. If it works for you as an antidepressant, I would like to put it on my list of things to try. Unfortunately, taking melatonin seems to make me feel worse.
- Scott
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.