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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by platinumbride on September 26, 2005, at 8:22:26
Lord, this is one weird drug. The fatigue and malaise kept me home from work for 3 days. And I am nowhere near the full dose!
I've tried taking it at night only. That would be OK if i could sleep for 10 hours each night!!!
I'm wondering if one gets more energy and motivation from this as the dose increases.
I have never felt so accutely, the sense that I am MEDICATED.
It would be great to have 3 weeks off from work to see if the s/es pass or if I should toss this.
You'd think a dopamine agonist would be activating!
Diane
Posted by iforgotmypassword on September 26, 2005, at 8:32:31
In reply to mirapex side-effects - experiences?, posted by platinumbride on September 26, 2005, at 8:22:26
Posted by platinumbride on September 26, 2005, at 9:03:28
In reply to this was my exact experience as well... : ( ... (nm) » platinumbride, posted by iforgotmypassword on September 26, 2005, at 8:32:31
Were you able to stay on it? Did it ever help? Who does these damn studies anyway????? LOL
Diane
Posted by iforgotmypassword on September 26, 2005, at 9:39:40
In reply to Re: this was my exact experience as well... : ( ..., posted by platinumbride on September 26, 2005, at 9:03:28
> Were you able to stay on it? Did it ever help? Who does these damn studies anyway????? LOL
>
> Dianeno, i needed to discontinue it... which was suprisingly easy (a monograph warned of neurleptic malignant syndrome-like effects)... i didnt help at all, yet for some reason my doctor thought it was helping... :( and the studies... who knows. they didnt seem superoptimistic to begin with i guess. :(
Posted by Declan on September 26, 2005, at 23:25:28
In reply to Re: this was my exact experience as well... : ( .., posted by iforgotmypassword on September 26, 2005, at 9:39:40
They've managed to manufacture dysphoric dopamine agonists.
I take my hat off to them.
Declan
Posted by platinumbride on September 27, 2005, at 7:53:57
In reply to Re: this was my exact experience as well... : ( .., posted by Declan on September 26, 2005, at 23:25:28
LOL
Yes, I gues that is pretty amazing...
I have a new found empathy for those who get sick on ssris - not to mention snris and going off of any of the stupid things.I'm kinda getting ready to be depressed, on and off for life. (Melodramatic music, please)>
Diane
Posted by Tom Twilight on September 27, 2005, at 15:14:06
In reply to Re: this was my exact experience as well... : ( .. » Declan, posted by platinumbride on September 27, 2005, at 7:53:57
Mirapex like many drugs, good on paper, not so good in reality.
I've never tried Mirapex, but Bromocriptine, another DA Agonist made me very tired.You want an activating DA agonist?
Try Piribedil, it is D2 and 3 Agonist, also affects Noradrenaline receptors.
Again I've never tried it, but someone who did said it was activating and mood elivating.Guess what? Its only available in France to the best of my knowlage
Psychomotor and cognitive effects of piribedil,
a dopamine agonist, in young healthy volunteers
by
Schuck S, Bentue-Ferrer D, Kleinermans D,
Reymann JM, Polard E, Gandon JM, Allain H.
Laboratoire de Pharmacologie Experimentale et Clinique,
Universite de Rennes I - Faculte de Medecine,
CS 34317, 35 043 Rennes cedex, France.
Fundam Clin Pharmacol. 2002 Feb;16(1):57-65ABSTRACT
Piribedil is a dopamine agonist acting on D2 and D3 central nervous system dopamine receptors. This drug has been administered to 12 young healthy male volunteers (age 22 +/- 2 years) according to a single center randomized, double-blind, two ways cross-over, placebo controlled trial, including a washout period of one week. Placebo and piribedil were administered by a single intravenous infusion over 2 h (3 mg). Psychomotor performance and cognitive functions were assessed through a standardized and computerized psychometric tests battery and a continuous electroencephalogram (EEG) mapping. Piribedil improved simple reaction time (P=0.02), immediate (P=0.045 and 0.004), and delayed free recall (P=0.05), dual coding test (P=0.02) and increased theta and fast beta waves on the EEG (P < 0.05 and 0.001, respectively). No deleterious effect was observed on the tests exploring attention and concentration via the other procedures. It is concluded that a single intravenous perfusion of piribedil 3 mg improves alertness and the information processing speed within the central nervous system, in healthy volunteers.
This is the end of the thread.
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