Activating dopamine agonist-Piribedil

Posted by Tom Twilight on September 27, 2005, at 15:14:06

In reply to Re: this was my exact experience as well... : ( .. » Declan, posted by platinumbride on September 27, 2005, at 7:53:57

Mirapex like many drugs, good on paper, not so good in reality.
I've never tried Mirapex, but Bromocriptine, another DA Agonist made me very tired.
You want an activating DA agonist?
Try Piribedil, it is D2 and 3 Agonist, also affects Noradrenaline receptors.
Again I've never tried it, but someone who did said it was activating and mood elivating.
Guess what? Its only available in France to the best of my knowlage
Psychomotor and cognitive effects of piribedil,
a dopamine agonist, in young healthy volunteers
by
Schuck S, Bentue-Ferrer D, Kleinermans D,
Reymann JM, Polard E, Gandon JM, Allain H.
Laboratoire de Pharmacologie Experimentale et Clinique,
Universite de Rennes I - Faculte de Medecine,
CS 34317, 35 043 Rennes cedex, France.
Fundam Clin Pharmacol. 2002 Feb;16(1):57-65
ABSTRACT
Piribedil is a dopamine agonist acting on D2 and D3 central nervous system dopamine receptors. This drug has been administered to 12 young healthy male volunteers (age 22 +/- 2 years) according to a single center randomized, double-blind, two ways cross-over, placebo controlled trial, including a washout period of one week. Placebo and piribedil were administered by a single intravenous infusion over 2 h (3 mg). Psychomotor performance and cognitive functions were assessed through a standardized and computerized psychometric tests battery and a continuous electroencephalogram (EEG) mapping. Piribedil improved simple reaction time (P=0.02), immediate (P=0.045 and 0.004), and delayed free recall (P=0.05), dual coding test (P=0.02) and increased theta and fast beta waves on the EEG (P < 0.05 and 0.001, respectively). No deleterious effect was observed on the tests exploring attention and concentration via the other procedures. It is concluded that a single intravenous perfusion of piribedil 3 mg improves alertness and the information processing speed within the central nervous system, in healthy volunteers.

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mirapex side-effects - experiences? platinumbride 9/26/05
this was my exact experience as well... : ( ... (nm) » platinumbride iforgotmypassword 9/26/05
Re: this was my exact experience as well... : ( ... platinumbride 9/26/05
Re: this was my exact experience as well... : ( .. iforgotmypassword 9/26/05
Re: this was my exact experience as well... : ( .. Declan 9/26/05
Re: this was my exact experience as well... : ( .. » Declan platinumbride 9/27/05
Activating dopamine agonist-Piribedil Tom Twilight 9/27/05

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