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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by Tom Twilight on June 2, 2005, at 16:13:59
Hello everyone
Firstly I should point out that I’ve changed my name, I used to be called “The Resistance”.
I decided that the name was too aggressive, so I changed it :)I need to ask a question of my fellow babblers, especially Ed.
I’ve heard lots of bad things about the new formulation of US Nardil, for example that is causes more side effects, and is less effective.
The question is does the current UK Nardil formulation cause similar problems? Is it the same as the US formulation.?
P.S Thanks for the advice you gave me last week Ed, forgot to thank you!
Posted by Phillipa on June 2, 2005, at 18:25:31
In reply to Questions about the UK Nardil formulation? Ed!?, posted by Tom Twilight on June 2, 2005, at 16:13:59
Keep posting your old name like you just did til we get used to it. Tom Twilight? How did you pick this name? Fondly, Phillipa
Posted by ed_uk on June 2, 2005, at 18:40:31
In reply to Questions about the UK Nardil formulation? Ed!?, posted by Tom Twilight on June 2, 2005, at 16:13:59
Hi Tom!
>Firstly I should point out that I’ve changed my name, I used to be called “The Resistance”.
I decided that the name was too aggressive, so I changed it :)Love the new name!
>Is it the same as the US formulation.?
No, it's a slightly different formulation. The active drug, phenelzine sulphate, is identical but there a few differences in the 'inactive ingredients'.
I sent an email to the UK manufacturer to find out what the inactive ingredients were. Here is the reply.........
Dear Mr Sykes
Thank you for your enquiry about Nardil (phenelzine) tablets that has been passed onto Link Pharmaceuticals Limited as Marketing Authorisation Holder for this product.
The excipients in Nardil tablets are listed on the Patient Information Leaflet that should accompany the tablets that your friend receives. However for your information these are mannitol, povidone, magnesium stearate, maize starch, hydroxypropylcellulose, hydroxypropylmethylcellulose (E464), talc, polyvinylacetatephthalate, stearic acid, sunset yellow (E110), erythrosine (E127) and titanium dioxide (E171).
I hope that this is of information.
Yours sincerely
>The question is does the current UK Nardil formulation cause similar problems?
Ted_Brosnan (from Norway) is currently taking the UK Nardil. The last time we head from him he was doing very well. I don't think there's anything specifically wrong with the UK formulation of Nardil. I tried to find the posts where I compared the UK Nardil with the US Nardil in more detail but I couldn't find them :-(
>Thanks for the advice you gave me last week Ed, forgot to thank you!
You're welcome :-)
Kind regards,
Ed.PS. You're babblemail's off again!
Posted by Tom Twilight on June 3, 2005, at 3:55:43
In reply to Re: Questions about the UK Nardil formulation? Ed!? » Tom Twilight, posted by Phillipa on June 2, 2005, at 18:25:31
Hey Ed
Thanks for the info you gave me
Your a Star!
Sorry about babblemailI'd just like to say to everyone that I didn't change my name because I had a bad reputation!
My only worry about changing my name is that people will think this.Its good to hear from you Phillipa
The reason I changed my name to Tom Twilight was that my first name is Tom, and that I found I nurse at work with the Sir name Twilight (second name in US speak), I though it sounded cool.
Posted by Dr. Bob on June 3, 2005, at 6:26:33
In reply to Questions about the UK Nardil formulation? Ed!?, posted by Tom Twilight on June 2, 2005, at 16:13:59
Posted by ed_uk on June 3, 2005, at 8:37:00
In reply to Whats in a name?, posted by Tom Twilight on June 3, 2005, at 3:55:43
Hi Tom!
>Sorry about babblemail...
It's still off LOL!
Ed.
Posted by djmmm on June 3, 2005, at 10:30:57
In reply to Questions about the UK Nardil formulation? Ed!?, posted by Tom Twilight on June 2, 2005, at 16:13:59
> Hello everyone
>
> Firstly I should point out that I’ve changed my name, I used to be called “The Resistance”.
> I decided that the name was too aggressive, so I changed it :)
>
> I need to ask a question of my fellow babblers, especially Ed.
>
> I’ve heard lots of bad things about the new formulation of US Nardil, for example that is causes more side effects, and is less effective.
>
> The question is does the current UK Nardil formulation cause similar problems? Is it the same as the US formulation.?
>
> P.S Thanks for the advice you gave me last week Ed, forgot to thank you!
>
The "old" US formulation contained a pharmaceutical glaze applied to the pill BEFORE the sugar coating.The "New" US version does not contain the glaze, and is replaced by croscarmellose sodium-- provides superior drug dissolution and disintegration.
A UK version (by Celletech Uk) does not contain either.
In Sept of 2002, Pfizer and the FDA decided to change the forumulation by removing the Pharmaceutical glaze, which, in thier words, "...leads to variations in the dissolution performance of the drug product..." and replace it with Opadry Orange, which "improves the dissolution performance of the tablets"
According to thier own reports, the reformulated version's bioavailability is 5% LESS than the older version, but is still within the 80-125% allowed, but the overall dissolution is improved (less variation)
read this http://www.stratguitar.com/nmember/ndocs/11909SCF032_Bio_redacted.pdf
This is the end of the thread.
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