Posted by djmmm on June 3, 2005, at 10:30:57
In reply to Questions about the UK Nardil formulation? Ed!?, posted by Tom Twilight on June 2, 2005, at 16:13:59
> Hello everyone
>
> Firstly I should point out that I’ve changed my name, I used to be called “The Resistance”.
> I decided that the name was too aggressive, so I changed it :)
>
> I need to ask a question of my fellow babblers, especially Ed.
>
> I’ve heard lots of bad things about the new formulation of US Nardil, for example that is causes more side effects, and is less effective.
>
> The question is does the current UK Nardil formulation cause similar problems? Is it the same as the US formulation.?
>
> P.S Thanks for the advice you gave me last week Ed, forgot to thank you!
>
The "old" US formulation contained a pharmaceutical glaze applied to the pill BEFORE the sugar coating.The "New" US version does not contain the glaze, and is replaced by croscarmellose sodium-- provides superior drug dissolution and disintegration.
A UK version (by Celletech Uk) does not contain either.
In Sept of 2002, Pfizer and the FDA decided to change the forumulation by removing the Pharmaceutical glaze, which, in thier words, "...leads to variations in the dissolution performance of the drug product..." and replace it with Opadry Orange, which "improves the dissolution performance of the tablets"
According to thier own reports, the reformulated version's bioavailability is 5% LESS than the older version, but is still within the 80-125% allowed, but the overall dissolution is improved (less variation)
read this http://www.stratguitar.com/nmember/ndocs/11909SCF032_Bio_redacted.pdf
poster:djmmm
thread:506978
URL: http://www.dr-bob.org/babble/20050601/msgs/507290.html