![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by linkadge on April 28, 2005, at 17:39:26
Most AD's have the propensity of inducing seizures, but some more than others (ie Wellbutrin), which AD would be a first line treatment for a depressed Epileptic.
Linkadge
Posted by Mr.Scott on April 29, 2005, at 2:01:08
In reply to Least proconvulsant AD, posted by linkadge on April 28, 2005, at 17:39:26
1) Nardil
2) Lexapro/Celexa
Posted by iforgotmypassword on April 29, 2005, at 17:45:34
In reply to Re: Least proconvulsant AD » linkadge, posted by Mr.Scott on April 29, 2005, at 2:01:08
i thought celexa was worse than wellbutrin and it was just some strange red tape like stuff that made it neccessary for the company to note the decreased seizure threshold?
Posted by mattw84 on April 29, 2005, at 21:50:04
In reply to Least proconvulsant AD, posted by linkadge on April 28, 2005, at 17:39:26
Avoid most all heterocyclics... stick with the Tricyclics, like amitryptiline or farther of trazodone - in spite of my rantings of it's use as a hypnotic or treatment for insomnia, you may be an ideal candidate. Antipsychotics also lower the seizure threshold, so avoid those. You might just be one of the "lucky ones" that has a case to justify opioid treatment.
Best of luck link!
Regards,
M.W.
Posted by iforgotmypassword on April 30, 2005, at 19:01:04
In reply to Re: Least proconvulsant AD, posted by mattw84 on April 29, 2005, at 21:50:04
lucky?! what kind of psychiatric doctors in this world actually give out opiods even if its the only moral thing to do?
Posted by Phillipa on April 30, 2005, at 19:46:50
In reply to Re: Least proconvulsant AD, posted by iforgotmypassword on April 30, 2005, at 19:01:04
One who knows the pt won't abuse them and nothing else has worked. Fondly, Phillipa
Posted by linkadge on April 30, 2005, at 22:57:40
In reply to Re: Least proconvulsant AD » iforgotmypassword, posted by Phillipa on April 30, 2005, at 19:46:50
If ECT works by causing a seizure, is there theraptutic effect in these meds being slightly proconvulsant.
Linkadge
Posted by etoc on May 5, 2005, at 20:44:49
In reply to is lowering seizure threshold theraputic, posted by linkadge on April 30, 2005, at 22:57:40
> If ECT works by causing a seizure, is there theraptutic effect in these meds being slightly proconvulsant.
>
> Linkadge<><>><><><>
Actually, it's the reverse. Each successive session of ECT Highers your seizure threshold. So in theory, the end effect of ECT is a temporarily or semi-permanently highered seizure thershold.It's possible that the effect of ECT, is actually not stimulation of the brain or even the actual seizure itself, but rather, the end result of a higher seizure threshold.
It also bears note that the reason for needed continual ECT session is to keep the brain from returning to it's previous seizure threshold limit.
Posted by Chairman_MAO on May 6, 2005, at 11:08:52
In reply to is lowering seizure threshold theraputic, posted by linkadge on April 30, 2005, at 22:57:40
It is not that lowering the seizure threshold is therapeutic, it's that increased activity in the CNS in different places can be therapeutic. Increased CNS activity pretty much equates with a lowered seizure threshold, given that a seizure is just way too much activity such that it gets out of control.
ECT works purportedly because the specific types of convulsions induce a complex neuroendocrinological cascade that results in the therapeutic effect. It is not the convulsion per se that is therapeutic, it is the result of it.
Strychnine in extremely low doses is a smart drug. Today, one of the drugs that is used as a standard "reference" convulsant in animal studies used to be a "tonic" marketed to the elderly for vitality ("metrazol" or something, I think).
In summary, a lowered seizure threshold is a correlate, not the cause, of the therapeutic effect.
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.