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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by dondon on February 8, 2005, at 16:15:13
When i take antipsychotics at the same time as dexedrine it dampens the effects of dexedrine. I have adhd and psychosis so I need them both
Posted by lunesta on February 8, 2005, at 16:17:37
In reply to amphetamines with antipsychotics, posted by dondon on February 8, 2005, at 16:15:13
that makes perfect sense. Amphetamines increase dopamine release... and neuroleptics stop or lower dopamine release.
Posted by dondon on February 8, 2005, at 16:23:17
In reply to Re: amphetamines with antipsychotics » dondon, posted by lunesta on February 8, 2005, at 16:17:37
Dexedrine and seroquel seems to be a good combo. Seroquel and clozapine are the only antipsychotics that don't dampen the effects of dexedrine.
Posted by banga on February 8, 2005, at 17:58:52
In reply to Re: amphetamines with antipsychotics, posted by dondon on February 8, 2005, at 16:23:17
> Dexedrine and seroquel seems to be a good combo. Seroquel and clozapine are the only antipsychotics that don't dampen the effects of dexedrine.
Does that include Abilify?
Posted by rod on February 10, 2005, at 8:04:26
In reply to Re: amphetamines with antipsychotics » dondon, posted by lunesta on February 8, 2005, at 16:17:37
> that makes perfect sense. Amphetamines increase dopamine release... and neuroleptics stop or lower dopamine release.
>
>
>
>Well, actually neuroleptics *INCREASE* the release of dopamine, but on the other hand block activation of dopamine receptors. They alwsays also block the autoreceptors, which is responsible for the increase in release. But affinity towards autorecept and prostsynaptic receptors are not neccessarily equal.
Just think about sulpiride, amisulpride...In your case, postsynaptic blockade just overrides and blocks the extra dopamine which is available due to amphetamine use.
bye
Posted by Eve1979 on February 12, 2005, at 22:57:01
In reply to Re: amphetamines with antipsychotics, posted by banga on February 8, 2005, at 17:58:52
What is dexadrine?
I am on wellbutrin and I believe i have adhd but my pdoc insists that I try anti depressants befoer the add meds. Does Wellbutrin and Adderall/Ritalin work well together? Anyone have the experience.
Posted by jparsell82 on February 16, 2005, at 18:10:29
In reply to amphetamines with antipsychotics, posted by dondon on February 8, 2005, at 16:15:13
> When i take antipsychotics at the same time as dexedrine it dampens the effects of dexedrine. I have adhd and psychosis so I need them both
I think the problem lies with the D2 blocking of antipsychotics. The best options you have would probably be seroquel, clozaril or abilify.
Seroquel doesn't block D2 receptors as much unless you get into higher doses. Clozaril blocks D4 the most, although it still blocks D2 receptors. Abilify is said to be a partial agonist of D2 receptors, but I didn't have a good experience with it myself. Good luck!
This is the end of the thread.
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