Posted by rod on February 10, 2005, at 8:04:26
In reply to Re: amphetamines with antipsychotics » dondon, posted by lunesta on February 8, 2005, at 16:17:37
> that makes perfect sense. Amphetamines increase dopamine release... and neuroleptics stop or lower dopamine release.
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>Well, actually neuroleptics *INCREASE* the release of dopamine, but on the other hand block activation of dopamine receptors. They alwsays also block the autoreceptors, which is responsible for the increase in release. But affinity towards autorecept and prostsynaptic receptors are not neccessarily equal.
Just think about sulpiride, amisulpride...In your case, postsynaptic blockade just overrides and blocks the extra dopamine which is available due to amphetamine use.
bye
poster:rod
thread:455073
URL: http://www.dr-bob.org/babble/20050207/msgs/455822.html