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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by ravenstorm on February 7, 2005, at 20:43:18
Before I even ask my questions I have to thank Scott (SLS) for his wonderful chart on psychiatric meds. Without that, I wouldn't even be able to ask these questions, or attempt to draw comparisons (however, futile my queries may end up being!).
OK.
First, what is the difference between an
NE-alpha1 antagonist and an NE-alpha2 antagonist?Second, if I am irritable, angry and anxious on remeron, which works as an NE-alpha2 antagonist, would I also, in theory, find buspar (which also works as an NE-alpha2 antagonist) to cause the same side effects?
What about drugs that are NE-alpha1 antagonists? Serzone falls into this category, and I was never angry or anxious on serzone (BUT I was still on 5mg paxil--trying to wean off--so perhaps that made the difference?) I was also barely awake the whole time I was on it (again, I sometimes wonder if an interplay between paxil and serzone might have also heightened the drowsiness affect). I see that seroquel is also an NE-alpha1 antagonist. At a low dose would that make me irritable or not? (Since serzone didn't)
Is risperdal an NE-alpha1 or 2 antagonist? (Scott's chart doesnt specify)
Just wondering. Or is it basically just a total flip of the coin? (ie an NE-alpha 1 antagonist in one drug might affect me totally differently than that of another drug)
Any broad information about the two types of alpha antagonists (and which kind risperdal works on) would be greatly appreciated. Or if you have personal experience with the two types and how they affect you, feel free to chime in.
Thanks.
Posted by Phillipa on February 7, 2005, at 21:29:04
In reply to Questions on NE alpha antagonists, posted by ravenstorm on February 7, 2005, at 20:43:18
I thought buspar was for anxiety? If remeron is the same type, wouldn't that mean it was anti-anxiety too? This is getting quite confusing for my febile brain! Fondly, Phillipa
Posted by Phillipa on February 7, 2005, at 21:30:51
In reply to Questions on NE alpha antagonists, posted by ravenstorm on February 7, 2005, at 20:43:18
I forgot. Then what is Cymbalta? Fondly, Phillipa
Posted by Ritch on February 8, 2005, at 0:19:49
In reply to Questions on NE alpha antagonists, posted by ravenstorm on February 7, 2005, at 20:43:18
>..First, what is the difference between an
NE-alpha1 antagonist and an NE-alpha2 antagonist?Second, if I am irritable, angry and anxious on remeron, which works as an NE-alpha2 antagonist, would I also, in theory, find buspar (which also works as an NE-alpha2 antagonist) to cause the same side effects?
What about drugs that are NE-alpha1 antagonists? Serzone falls into this category, and I was never angry or anxious on serzone
I found Buspar to defnitely trigger very very bad temper spells for me, very similar to Remeron. The alpha-1 antagonists that I've taken such as trazodone and serzone, and Mellaril.. etc. didn't make me angry either. What those seem to do is cause *dizziness* as a s/e more than anything else, and nasal congestion (vasodilation?). I would like to see a good explanation of the differences too..
Posted by tensor on February 8, 2005, at 5:42:13
In reply to Questions on NE alpha antagonists, posted by ravenstorm on February 7, 2005, at 20:43:18
Hi Ravenstorm!
> First, what is the difference between an
> NE-alpha1 antagonist and an NE-alpha2 antagonist?> Any broad information about the two types of alpha antagonists (and which kind risperdal works on) would be greatly appreciated.
Maybe you'll find this site interesting:
http://www.merck.com/mmhe/sec02/ch012/ch012b.htmlRegards,
Mattias
Posted by Ritch on February 8, 2005, at 9:24:39
In reply to Re: Questions on NE alpha antagonists » ravenstorm, posted by tensor on February 8, 2005, at 5:42:13
Thanks Mattias!
Hmmm. So it looks like norepinephrine *release* is the culprit...
Posted by Maxime on February 8, 2005, at 21:30:13
In reply to Re: Questions on NE alpha antagonists » ravenstorm, posted by Phillipa on February 7, 2005, at 21:29:04
Hi, where might I find Scott's chart?
Maxime
Posted by Maxime on February 8, 2005, at 21:31:55
In reply to Re: Questions on NE alpha antagonists » tensor, posted by Ritch on February 8, 2005, at 9:24:39
Is it this?
http://sl.schofield3.home.att.net/medicine/psychiatric_drugs_chart.html
Posted by ravenstorm on February 8, 2005, at 23:07:25
In reply to Re: Questions on NE alpha antagonists - is it this, posted by Maxime on February 8, 2005, at 21:31:55
Thats it! Thanks for the input guys. Any more information from anyone? Which type is risperdal?
This is the end of the thread.
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