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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by scott-d-o on February 2, 2004, at 19:05:39
I am actually seeking this "side effect" so I was somewhat disappointed when I saw that Lexapro's manufacturer claims a lower incidence of sexual SE's compared to other antidepressants.
However, there are clinical trials that show the drug's predecessor, Celexa, works very well for this purpose. I am wondering if they are both just as likely to cause delayed ejaculation or if possibly the R-enantiomer present in citalopram, but not in Lexapro, may play a role in inducing these effects.
Also, I am wondering how Lexapro could possibly have a lower incidence of sexual SE's when it is the *most* selective AD out there for the serotonin transporter. You would think that the other AD's would be less likely to have sexual SE's since they also have some action at the dopamine and norepinephrine transporters..
So I guess my question is, are there any males out there that have tried both Celexa and Lexapro and noticed any differences in sexual "endurance" between the two? ..or any comparisons between Celexa/Lexapro and other SSRI's when it comes to sexual side effects are also appreciated..
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The efficacy of citalopram in the treatment of premature ejaculation: a placebo-controlled study.
Atmaca M, Kuloglu M, Tezcan E, Semercioz A.
Firat University, School of Medicine, Department of Psychiatry, Elazig, Turkey. matmaca_p@yahoo.com
BACKGROUND: Despite the limited number of available study comparing of their efficacy, selective serotonin re-uptake inhibitors (SSRI) have been thought to have beneficial effects for the patients with premature ejaculation. In the present study, we decided to examine the efficacy of citalopram, an SSRI, in the treatment of premature ejaculation. METHOD: The study was consisted of 26 married patients diagnosed with premature ejaculation according to Diagnostic and Statistical Manual of Mental Disorders Third Revised Version (DSM-III-R). The patients were randomly assigned to two groups, citalopram (group I) and placebo (group II), each consisting of 13 patients. The effects of drug on the ejaculatory function were assessed by the intravaginal ejaculation latency time. Additionally, all patients were screened by using Clinical Global Impression-Improvement Scale (CGI-I) and Yonsei Sexual Function Inventory-II (YSFI-II). RESULTS: The increase in the intravaginal ejaculation latency time in the citalopram group was statistically significant than that of placebo group. In addition, with respect to the subscales of the YSFI-II scale, similar overall significant improvements were seen in the patients given citalopram compared to those given placebo. Of group I patients, five (38.5%) were considered as 'very much improved' and four (30.8%) 'much improved' by CGI-I and only one of group II patients (7.7%) showed 'much improved'. CONCLUSION: The patients treated with citalopram showed significantly greater improvement compared to the patients receiving placebo.
Publication Types:
* Clinical Trial
* Randomized Controlled Trial
PMID: 12494286 [PubMed - indexed for MEDLINE]
Posted by Wildman on February 3, 2004, at 4:51:21
In reply to delayed ejaculation; lexapro vs. celexa?, posted by scott-d-o on February 2, 2004, at 19:05:39
> I am actually seeking this "side effect" so I was somewhat disappointed when I saw that Lexapro's manufacturer claims a lower incidence of sexual SE's compared to other antidepressants.
Well, if you are _seeking_ that side effect, Lexapro may fit the bill. It does not make ejaculation impossible, but you gotta work at it :)
> So I guess my question is, are there any males out there that have tried both Celexa and Lexapro and noticed any differences in sexual "endurance" between the two?Have only tried Lexapro, never anything else. The side effect only delays, but does not eliminate ejac. If you have enough "experience" with this side effect, it can be good thing. The problem is the first two or three times, that you think it will never happen. You'll learn what works. :) Your partner will not complain about this...
Posted by Bill LL on February 3, 2004, at 8:45:38
In reply to delayed ejaculation; lexapro vs. celexa?, posted by scott-d-o on February 2, 2004, at 19:05:39
You are not alone. Docs prescribe SSRI's to treat pre-mature ejaculation. I used to take Celexa and now take Lexapro. I can't comment on which causes more sexual side effects because I have been on different doses of each and the side effect probably increases with the dose. My guess is that Lexapro causes less side effects.
Don't try to figure things out based on serotonin specificity. Scientists do not know how these drugs work. For that matter, they don't fully understand the various effects of aspirin. It's all trial and error.
Up until now, scientists thought that antidepressants might work by increasing serotonin, dopamine, and/or norepinephrine. According to a recent Newsweek magazine, the neurotransmitter model is losing support. The new model that most scientists are leaning towards is that antidepressants, by some unknown mechanism, work by increasing the size of a portion of the brain called the hippocampus.
Posted by JonW on February 3, 2004, at 20:05:06
In reply to delayed ejaculation; lexapro vs. celexa?, posted by scott-d-o on February 2, 2004, at 19:05:39
I've been on both and in my experience, Celexa is far more potent in this regard.
Jon :)
Posted by HenryO on February 4, 2004, at 2:22:53
In reply to delayed ejaculation; lexapro vs. celexa?, posted by scott-d-o on February 2, 2004, at 19:05:39
Be careful. Delayed for now, but eventually it may be not at all. With Prozac I thought it was cool at first too, but as months turned to years performance and desire began to fade. There is a lessening of interest that is so slow and subtle, it takes time to spot. When meds knock out your libido and your erections that is depressing. Try a dose of Viagra. Your doctor will write a scrip like he's earning frequent flyer miles for it. Just say things aren't what they were when you were seventeen. They can't wait to give you this stuff. You can break up the pills. It is rocket fuel. Viagra alone has been shown to help with depression.
Posted by scott-d-o on February 4, 2004, at 16:13:03
In reply to Re: delayed ejaculation; lexapro vs. celexa?, posted by HenryO on February 4, 2004, at 2:22:53
> Be careful. Delayed for now, but eventually it may be not at all. With Prozac I thought it was cool at first too, but as months turned to years performance and desire began to fade. There is a lessening of interest that is so slow and subtle, it takes time to spot. When meds knock out your libido and your erections that is depressing. Try a dose of Viagra. Your doctor will write a scrip like he's earning frequent flyer miles for it. Just say things aren't what they were when you were seventeen. They can't wait to give you this stuff. You can break up the pills. It is rocket fuel. Viagra alone has been shown to help with depression.
Seventeen was not that long ago for me, so I don't think this will be much of a problem.. I think a lessening of libido could help my depression as well.. maybe I wouldn't be so depressed if I wasn't thinking about sex all the time (i.e. how I hardly ever get it), then I could concentrate on other things..
who knows, with less of a libido I might actually do something with my life!
thanks for the replies.. to the person that said they were on Lexapro and Celexa at different doses: 10mg Lexapro = 40mg Celexa, so that provides a basis for comparison.
scott
Posted by HenryO on February 5, 2004, at 3:29:01
In reply to Re: delayed ejaculation; lexapro vs. celexa?, posted by scott-d-o on February 4, 2004, at 16:13:03
Sorry my mistake. If you want to crush your libido, I would recomend good doses of Nurontin and Prozac. That should do it.
Posted by scott-d-o on February 5, 2004, at 22:55:58
In reply to Re: delayed ejaculation; lexapro vs. celexa?, posted by HenryO on February 5, 2004, at 3:29:01
> Sorry my mistake. If you want to crush your libido, I would recomend good doses of Nurontin and Prozac. That should do it.
well, i'm on lexapro (10mg/d) and klonopin (1.5mg/d) and it's still going strong.. I think I need to give the lexapro more time. the adderall can't be helping the cause either..
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