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delayed ejaculation; lexapro vs. celexa?

Posted by scott-d-o on February 2, 2004, at 19:05:39

I am actually seeking this "side effect" so I was somewhat disappointed when I saw that Lexapro's manufacturer claims a lower incidence of sexual SE's compared to other antidepressants.

However, there are clinical trials that show the drug's predecessor, Celexa, works very well for this purpose. I am wondering if they are both just as likely to cause delayed ejaculation or if possibly the R-enantiomer present in citalopram, but not in Lexapro, may play a role in inducing these effects.

Also, I am wondering how Lexapro could possibly have a lower incidence of sexual SE's when it is the *most* selective AD out there for the serotonin transporter. You would think that the other AD's would be less likely to have sexual SE's since they also have some action at the dopamine and norepinephrine transporters..

So I guess my question is, are there any males out there that have tried both Celexa and Lexapro and noticed any differences in sexual "endurance" between the two? ..or any comparisons between Celexa/Lexapro and other SSRI's when it comes to sexual side effects are also appreciated..

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The efficacy of citalopram in the treatment of premature ejaculation: a placebo-controlled study.

Atmaca M, Kuloglu M, Tezcan E, Semercioz A.

Firat University, School of Medicine, Department of Psychiatry, Elazig, Turkey. matmaca_p@yahoo.com

BACKGROUND: Despite the limited number of available study comparing of their efficacy, selective serotonin re-uptake inhibitors (SSRI) have been thought to have beneficial effects for the patients with premature ejaculation. In the present study, we decided to examine the efficacy of citalopram, an SSRI, in the treatment of premature ejaculation. METHOD: The study was consisted of 26 married patients diagnosed with premature ejaculation according to Diagnostic and Statistical Manual of Mental Disorders Third Revised Version (DSM-III-R). The patients were randomly assigned to two groups, citalopram (group I) and placebo (group II), each consisting of 13 patients. The effects of drug on the ejaculatory function were assessed by the intravaginal ejaculation latency time. Additionally, all patients were screened by using Clinical Global Impression-Improvement Scale (CGI-I) and Yonsei Sexual Function Inventory-II (YSFI-II). RESULTS: The increase in the intravaginal ejaculation latency time in the citalopram group was statistically significant than that of placebo group. In addition, with respect to the subscales of the YSFI-II scale, similar overall significant improvements were seen in the patients given citalopram compared to those given placebo. Of group I patients, five (38.5%) were considered as 'very much improved' and four (30.8%) 'much improved' by CGI-I and only one of group II patients (7.7%) showed 'much improved'. CONCLUSION: The patients treated with citalopram showed significantly greater improvement compared to the patients receiving placebo.

Publication Types:

* Clinical Trial
* Randomized Controlled Trial


PMID: 12494286 [PubMed - indexed for MEDLINE]


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poster:scott-d-o thread:308641
URL: http://www.dr-bob.org/babble/20040131/msgs/308641.html