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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by freedom2001 on August 29, 2003, at 0:33:09
Antidepressants and Cancer
The FDA requires that all psychiatric medications be tested in animal studies for possible enhanced cancer risk. These are usually done with rodents. However, medications are often approved even if the medication causes cancer in rats. The box score on three drugs is as follows:
Paxil: Male rats exhibited increased incidence of lymphoreticular tumors & cell sarcomas.
Prozac: No evidence of carcinogenesis.
Zyprexa: Mammary gland adenomas and adenocarcinomas found in rats, suggesting possible increased risk of breast cancer. Increased prolactin levels which has been associated with increased risk of hormonal cancers....breast, ovarian, etc. Also one of two studies indicated increased incidence of liver cancer. (Feb 24, 2003)
Posted by linkadge on August 29, 2003, at 6:36:29
In reply to ANTI-DEPRESSANTS AND CANCER, posted by freedom2001 on August 29, 2003, at 0:33:09
Many of the tricylcics has a *slight* increase in the occurance of cancers, execpt doxepin I beleive.
Some of the drugs may only be increasing cancer likelyhood indirectly. Ie many people on Paxil say it is more sedating and perhaps leads to more weight gain. Some of these factors may accound for the increased risk. Not exactly sure
Linkadge
Posted by freedom2001 on August 29, 2003, at 10:14:29
In reply to triciclics, posted by linkadge on August 29, 2003, at 6:36:29
> Many of the tricylcics has a *slight* increase in the occurance of cancers, execpt doxepin I beleive.
>
> Some of the drugs may only be increasing cancer likelyhood indirectly. Ie many people on Paxil say it is more sedating and perhaps leads to more weight gain. Some of these factors may accound for the increased risk. Not exactly sure
>
>
> LinkadgeSo rodents on paxil got cancer. Is it because they have become too FAT???? :)
Just wondering....
My own opinion is that they do not get cancer because they get too fat. The rodents just had a higher chance of getting cancer on Paxil.
I hope it doesn't happen to humans.....
I was on paxil once....quite good effects...but now I'm on generic prozac as it is the cheapest.
Freedom.
Posted by stjames on August 29, 2003, at 10:48:57
In reply to ANTI-DEPRESSANTS AND CANCER, posted by freedom2001 on August 29, 2003, at 0:33:09
It would be nice to include the source of this study. However, animal studies use huge doses to produce their effects. So all I think this does is scare people, esp. in caps.
Posted by linkadge on August 29, 2003, at 11:35:51
In reply to Re: ANTI-DEPRESSANTS AND CANCER, posted by stjames on August 29, 2003, at 10:48:57
I don't necesarily mean too fat, but the drugs can change the way that a person behaves.
For instance, on paxil a person might be
prone to eating a little more, exercising
a little less etc. Just general lifestyle
changes that might increase the risk of
cancer.I know it is most likely the fact that
the molecule itself is somewhat carcinogenic
but I am just trying to see the other possible
side.The same sort of thing goes with Remeron.
While on the drug, clinical studies reveal
a notable rise in cholesterol levels. The
question arises - does the molecule itself
raise cholesterol or does the fact that
the patient tends to eat more on Remeron
raise cholesterol??Linkadge
Posted by freedom2001 on August 29, 2003, at 11:42:18
In reply to Re: ANTI-DEPRESSANTS AND CANCER, posted by linkadge on August 29, 2003, at 11:35:51
> I don't necesarily mean too fat, but the drugs can change the way that a person behaves.
>
> For instance, on paxil a person might be
> prone to eating a little more, exercising
> a little less etc. Just general lifestyle
> changes that might increase the risk of
> cancer.
>
> I know it is most likely the fact that
> the molecule itself is somewhat carcinogenic
> but I am just trying to see the other possible
> side.
>
> The same sort of thing goes with Remeron.
> While on the drug, clinical studies reveal
> a notable rise in cholesterol levels. The
> question arises - does the molecule itself
> raise cholesterol or does the fact that
> the patient tends to eat more on Remeron
> raise cholesterol??
>
> Linkadge
>
>
>What I'm concerned about are those patients on paxil. Will they have an increased chance of getting cancerous growths than those on Prozac?
Only God knows I guess....
Hope a new and more effective anti-OCD drug comes out soon...and affordable and available worldwide...
Freedom.
Posted by linkadge on August 29, 2003, at 15:05:27
In reply to Re: ANTI-DEPRESSANTS AND CANCER » linkadge, posted by freedom2001 on August 29, 2003, at 11:42:18
In the case that the cancer stems from the molecule itself, it may be wise to switch to another similar drug.
I beleive the one that is most similar (on the standpoint of activation) is Celexa, perhaps Luvox.Linkadge
This is the end of the thread.
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